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Medicinal Chemistry, Pharmaceuticals Sciences, and Pharmacy

University of Bari,Italy

Pharmaceutical Sciences of the University of Bari

Main Areas of Interest

Medicinal Chemistry, Pharmaceuticals Sciences, and Pharmacy Fellowship: This is a Trialect Partnered Program

The Department of Pharmacy - Pharmaceutical Sciences of the University of Bari, Italy, and specifically our laboratory can provide short term hands-on traineeship/fellowship (6-12 weeks) in the areas of Medicinal Chemistry. The lab offering you the traineeship is one of the leading labs in the world dealing with enzymes as drug targets in oncology and, neurological and neurodegenerative diseases. Currently, the Cyclooxygenase(COX)-1 as a pharmacological target to be reconsidered is under investigation. Only 3 positions are available. We appreciate if you can refer your students/colleagues/fellows (physicians/biomedical scientists) who may be interested in the program. This highly productive lab will help co-author a few papers, and in addition is interested in long term collaboration with the fellows who go through training.

The lab will help you with low cost accommodation in the "Campus X" residence

Specialties

Pharmaceuticals

Techniques You Will Learn

Experimental techniques you will learn hands-on during your program here:

customized synthetic strategies to prepare drug active principle ingredients
compounds isolation techniques (i.e., thin layer and column chromatography)
compounds purification techniques: distillation and crystallization
compounds identification: nuclear magnetic resonance spectrometry, (proton, 13 carbon, 31 phosphorous, Š.), ultraviolet spectrophotometry (UV), infrared spectrometry (IR), mass spectrometry, fluorescence spectrometry, elemental analysis.
drug analysis (also counterfeit drugs) by using the "compounds identification techniques" and Gas- chromatography (GC and GC-Mass), High Performance chromatography (HPLC with - UV-diode array, light scattering, fluorescence, refractive index as detectors),
development of fluorescent probes for receptors/enzymes visualization by high content imaging system in living cells for early diagnosis of tumors.
cell culture
cell viability and toxicity assay
cyclooxygenases activity determination
in vitro intestinal drug adsorption
in vitro Metabolic stability studies and metabolites characterization by mass spectroscopy and/or NMR analyses.
O2 consumption determination assay
ELISA
flow cytometry FC500 Beckman Coulter
plasma protein binding assay

Equipments: The Department of Pharmacy - Pharmaceutical Sciences of the University of Bari, Italy, (http://www.farmacia.uniba.it/), is a research and teaching that provides a very deep knowledge on Drug Sciences. The Department is fully equipped to carry out the program outlined above. In particular: (a) instruments for structure assignment to the novel or known compounds: NMR-Varian Inova 400 MHz and-Bruker Aspect 3000 console 500 MHz-FTIR-PerkinElmer 681 spectrometer-GC°VMS from Hewlett-Packard 5995C, Elemental Analyzer 1106-Carlo Erba instrument- ESI-MS analyses-Agilent 1100 LC/MSD trap system VL-Spectrophotomer UV-1800- Schimidazu HPLC from Agilent 1260 Infinity instrument equipped with a 1260 DAD VL+, Refractive Index and Fluorescence detector. (b) instruments for the bio-pharmacological investigation: Microplate reader Victor 3 from PerkinElmer Life Sciences; PerkinElmer LS55 luminescence spectrofluorimeter; Gallios Flow Cytometer-PerkinElmer; Operetta® High Content Imaging System-PerkinElmer; ABI PRISM 7000 Instrument (Applied Biosystem); VersArray confocal imaging system (Bio-Rad); Flow cytometer FC500 Beckman Coulter; Tecan microplate reader Infinite M1000 PRO; Oxytherm System - Hansatech Instruments (c) all the other instruments typically present in molecular and cellular biology laboratories.

Curriculum

Can Be Customized

Accommodation

Try Airbnb

Accommodation and living expenses will come to around $150 per week at http://www.campusx.it/bari/

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.

Who Can Apply

Faculty and Students interested in the above fields are invited

Host Details

Host Name: Prof. Antonio Scilimati

Affiliation: University of Bari,Italy

Address: Pharmaceutical Sciences of the University of Bari, Italy

Website URL: http://www.farmacia.uniba.it/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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