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Cardiovascular Diseases Research

IRCCS Ospedale San Raffaele, Milan

IRCCS Ospedale San Raffaele, Milan, Italy

Main Areas of Interest

IRCCS Ospedale San Raffaele (http://www.hsr.it/) in Milano is a university and research hospital, established in 1971 to provide specialized care for the most complex and difficult health conditions. IRCCS Ospedale San Raffaele is one of the leading research institutes in Italy as per volume and quality of scientific output. Since 2001, Ospedale San Raffaele has been recognized by the Italian Ministry of Health as a research hospital (Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS) with the specialty of Molecular Medicine. This specialty recognizes the multidisciplinary research carried out at the institute, which focuses at both understanding the molecular processes underlying a large number of human diseases and designing new approaches for their treatment. Research at San Raffaele covers all fields of biomedicine and it deals with the overall biomedical innovation process: from basic discoveries made in the labs to therapy design and test in pre-clinical models, up to first-phase and pilot clinical trials in humans. Thanks to the integration of basic, translational and clinical research, Ospedale San Raffaele is at the forefront in many biomedical areas and provides the best assistance to its patients.

Area of interest of the hosting group: Our research group studies cardiovascular diseases. Specific research areas are:

- Molecular mechanisms of atherosclerotic plaque destabilization and vessel thrombogenicity

- Pathogenetic mechanisms of cardiomyopathies and of microvascular dysfunction

Techniques You Will Learn

- Experimental techniques the fellow could see/learn during the program:

- blood processing to plasma or PRP

- platelets quantification

- tissue processing/storage for molecular biology, biochemistry and microscopy purposes

- tissue cryosectioning

- mRNA and microRNA extraction from human cardiac and/or vascular tissues

- qRT-PCR

- microRNAs validation

- proteins extraction

- western blotting

- ELISA

- histology

- immunofluorescence

- fluorescence and confocal microscopy

- blood flow experiments on vascular sections

- human artery culture in static conditions and in the micro-bioreactor underflow

- cell culture and treatment

Curriculum

Can Be Customized

General aims/achievements of a 6-12 weeks fellowship:

A desk space with PC will be allocated. Full induction (safety, laboratory practices, personal welfare, etc.) information will be provided by the OSR protection and prevention service (PPS) designated staff and by myself. An initial meeting will be arranged with the fellow to discuss his/her skills and scientific expectancies, and the objectives of the training. Experimental plans with realistic timelines will be decided. The fellow will be provided of basic literature concerning the scientific theme object of his/her training and trained to run experiments before attempting any. The trainer will be present to provide support during their first run by the fellow. He/she will acquire autonomy in at least one methodology, including data analysis. The fellow will keep adequate records of the work done on a personal laboratory book and his/her activities will be weekly scheduled based on the technical progress and data generated. The fellow will have an open discussion about the aspects of the general running of the laboratory, or specific protocols, and scientific brainstorm with the supervisor and the other team members. The fellow will be given an opportunity to participate in institutional seminars and encouraged to present the results obtained at a research group meeting before leaving, at the end of the attending period. The opportunity (and how) to be involved in disseminating the obtained data and integrating with those produced by the team, will be taken into consideration if enough data generated by the fellow will be available. The training is aimed to improve and integrate the fellow’ knowledge and skills, to increase his/her competitivity, useful for his/her successive career.

Accommodation

Possible accommodations near the lab (5-10 minutes walking)

- The NH Milano 2 Residence, a solution for those looking for a medium-long term accommodation. Guests of the Residence will find, in addition to furnished apartments, the possibility of shared services with the nearby hotel, such as the bar, the terrace and the gym. For more information, contact the property directly. The Residence has 50 rooms and 84 apartments. The rooms are comfortable and bright, decorated in warm, autumn colors and have panoramic views of the lake and the park. We also have apartments with one, two and three bedrooms, kitchenette, sitting room and a relaxing view of the park. All rooms have free Wi-Fi and satellite TV. https://www.nh-hotels.it/hotel/nh-milano-2?gmb ; nhmilano2residence@nh-hotels.com

- Hotel Rafael, located close by San Raffaele Hospital. It is a new building, which makes the most of its position to guarantee excellent links to the city and the main transport routes (from 90€/day, bed and breakfast). http://www.rafaelhotel.it/en

San Raffaele Hospital is served by ATM public transportation, i.e. Bus 925 and a shuttle, both from/to MM2 Cascina Gobba stop.

Fees and Program Logistics

This program has the following durations available:

Duration	Fee

Who Can Apply

Physicians and Scientists from around the world can apply

Host Details

Host Name: Foglieni Chiara

Affiliation: IRCCS Ospedale San Raffaele, Milan

Address: IRCCS Ospedale San Raffaele, Milan, Italy

Website URL: http://www.hsr.it/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.