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ASAP Collaborative Research Network--Scientific Track

Aligning Science Across Parkinson’s (ASAP)

In early 2025, ASAP offered two open, competitive funding opportunities for the research community to provide additional capital to spur discovery for Parkinson’s disease (PD) research

Scientific Track: Focus on supporting high-priority projects to dissect the mechanisms that contribute to PD heterogeneity.

Funding Scope

Funds provided by ASAP may be used for scientific and technical personnel, supplies, and standard equipment needs directly related to the successful execution of the proposed scope of work. ASAP funds may not be used for laboratory or facility renovation. As you prepare your budget, please remember that the maximum total amount requested per team per year is $2 million USD, inclusive of indirect costs.

The maximum total amount requested for the project is $6 million USD, inclusive of a 15% indirect rate applied to the team’s direct costs.

AI Based Application Success Predictor

🧪 1. Exact Alignment with ASAP Scientific Themes

Proposals must address ASAP’s high-priority research areas, such as:

Neuro-immune interactions

Circuitry & brain-body interactions (especially non-motor symptoms)

Functional genomics

Aging, clearance mechanisms, or alpha-synuclein seeding in PD 

👥 2. Structured Collaborative Networks

Must propose a team of 3–5 PIs across 2–5 institutions, including:

A lead PI in an independent faculty position

At least one early-career investigator

Multidisciplinary representation .

🔬 3. Direct Tie to Human PD Biology

Projects require a strong link to human datasets (e.g., clinical cohorts, PPMI).

Purely tool-development or motor-focused circuit studies are NOT in scope .

⏱️ 4. Feasible, Milestone-Oriented Research

Funding is up to US $3M/year for up to 3 years.

Proposals must include clear aims, deliverables, and timelines compatible with ASAP’s collaborative framework 

🔓 5. Strong Open Science Commitment

ASAP enforces strict open science policies:

Preprint posting

Public data/code sharing

Use of ASAP Hub or CRN Cloud resources.

🛠️ 6. Tailored Track-Specific Structure

Scientific Track: hypothesis-driven disease mechanism studies (as above).

Technical Track: tool/resource creation with teams combining PD biology, toolmanship, and distribution capabilities 

🔍 7. International & Multidisciplinary Excellence

Teams must be international, cross-disciplinary and integrate early-career researchers to foster collaboration and pipeline development .

📋 Summary Table

Predictor	What You Should Deliver
ASAP scientific fit	Align with ASAP’s focus areas (e.g., neuro-immune, aging)
Collaborative team structure	3–5 PIs, ≥2 institutions, early-career PI included
Human PD connection	Use human data cohorts, avoid basic tool-only projects
Feasible, milestone-driven plan	Structured goals with timeline, ready for $3M/year scale
Open science enforcement	Preprints posted, data & code shared openly
Track specificity	Scientific vs Technical track with correct setup
International & multidisciplinary	Combine global partners, disciplines, and ECI mentoring

🛠 Bonus Tips

Start with:

A strong Letter of Intent (due March 20, 2025)

Follow ASAP’s two-phase selection: LOI → full proposal → interviews (~January 2026) 

Embrace ASAP’s collaborative culture: Open science, consortium meetings, preprints, data sharing .

Define roles and responsibilities early, including project management and ECI integration.

Engage human PD resources (PPMI, global genetics, patient cohorts) in your design.

Ensure tool distribution feasibility for Technical Track (e.g., CRO partnerships, click-to-order mechanism) 

Specialties

Neurosciences

Eligibility Requirements

Institutional Eligibility

● Type – Applications may be submitted by public and private non-profit entities, such as universities, colleges, hospitals, laboratories, units of state and local governments, as well as eligible agencies of the federal government. For-profit entities are also encouraged to apply provided that the applicant holds a Senior Scientist position or equivalent and agrees to comply with all outlined policies & requirements including (but not limited to) the ASAP Open Science policy.

● Geographic Focus – Applications may be submitted by U.S. and foreign entities.

● Submitting Institution – The Coordinating Lead PI must be affiliated with the institution submitting the application and grant funds will be awarded to that institution, which will take responsibility for distributing funds to the institutions of the other members of the collaboration.

Core Leadership Eligibility

● Core Leadership – Each Team must consist of a minimum of two (2) to a maximum of five (5) PIs. A Coordinating Lead PI must be appointed for each Team, who will be responsible for overall project management and reporting to ASAP/MJFF staff throughout the lifecycle of each program. A Core/Repository Co-Investigator must be appointed for each Team, who will be responsible for commercialization of the resulting preclinical reagents/models. Team structure and management is discussed in further detail below.

● Disciplines Represented – There must be at least two (2) different research disciplines represented on each Team.

● Institutions – There must be a minimum of two (2), but no more than five (5) participating institutions represented by the Team. An absolute maximum of six (6) participating institutions as referenced in the exception above is applicable.

● Degree – All Core Leadership must hold a doctorate, such as a PhD, MD, or equivalent degree. The exception may be the Core/Repository Co-Investigator but this individual must be authorized to act on behalf of their Institution within this program.

● Appointment – The Coordinating Lead PI must have an academic appointment and be in an independent faculty position or equivalent. A Coordinating Lead PI from the private sector must hold a Senior Scientist position or equivalent. All other Core Leadership must be in an independent faculty position or equivalent. If applying from the private sector, the applicant must hold a Senior Scientist position or equivalent.

● Time Allocation – All Core Leadership except for the Core/Repository Co-Investigator must commit to a minimum allocation of 0.25 (25%) of their time and effort.

Ineligibility This RFA will not provide funding for the following types of projects:

● Projects to generate preclinical tools/models for targets outside the list provided by ASAP or projects that will not be generating preclinical tools/models.

● Projects performing hypothesis-driven research rather than generating and validating novel preclinical tools/models.

● Projects generating preclinical reagents/models that cannot or will not be rapidly shared with the research community through commercial mechanisms.

Sponsor Details

Sponsor Institute/Organizations: Aligning Science Across Parkinson’s (ASAP)

Sponsor Type: Corporate/Non-Profit

Address: 5425 Wisconsin Ave #600, Chevy Chase, MD 20815

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