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Alzheimer’s Disease Strategic Fund: Vascular Contributions to Cognitive Impairment and Dementia - Understanding Mechanisms of Dysfunction (VCID-UMD)

Alzheimer's Association

The Alzheimer’s Association aims to support innovative, high-risk, collaborative team science opportunities that investigate and focus on outstanding questions related to the biological underpinnings of Alzheimer’s disease (AD), including the vascular contributions to cognitive impairment and dementia (VCID). This new funding call builds off the last ten years of work to better understand VCID and its contributions to AD/ ADRD pathogenesis by targeting scientific questions on how VCID may intersect with immune, lipid and endolysosomal related functions to contribute to disease. This funding call will be supported through an innovative funding model, the Alzheimer’s Disease Strategic Fund, established in 2019 to support studies that advance our understanding of mechanistic and underpinning biology of disease.

Open to researchers at academic institutions and other non-profit research institutions. The Principal Investigator of the project must be a full-time faculty member (Assistant Professor, Instructor, Lecturer or higher).

Funding and award period

The maximum grant amount is $300,000; with anticipated funding ranges to be $150,000 to $300,000 depending on the project scope. Budget spending should be appropriately aligned to the specific aims and proposed milestones of the project. The maximum project duration is 3 years, and there is no minimum timeframe. No indirect costs will be allowed. The Association will evaluate projects on progress toward specific milestones; continued disbursement of funds is dependent on demonstrated progress toward key milestones.

AI Based Application Success Predictor

🎯 1. Alignment with Specific Focus Areas & RFAs

Each Funding Opportunity (e.g., Part the Cloud, ALZ‑RWD, specific RFA topics) has distinct research priorities. Success starts with tight alignment:

LOIs must clearly match the call objectives—addressing knowledge gaps, innovation, and AD/ADRD impact 

Projects involving real-world data must enhance platform infrastructure globally and promote equity

🧪 2. Innovation, Rigor & Methodological Strength

LOI review focuses on demonstrable novelty, rigor, and team science potential

Full proposals are judged on sound hypothesis, design quality, power calculations, and feasibility—backed by clear milestones .

👥 3. Team Composition & Track Record

Highlight the expertise and recent achievements of the PI and team. Multi-disciplinary collaboration is a plus .

Early-stage awards (e.g., fellowships) support diverse career stages; diversity-focused mechanisms value investigator potential 

📊 4. Feasible Planning & Structured Milestones

A detailed workplan with yearly milestones helps reviewers evaluate progress potential .

Strategic calls (e.g., translational drug programs) require IND-enabling path clarity 

📂 5. Data Sharing & Open Science Compliance

Data management and sharing plans are mandatory; budget for data sharing in proposals 

RWD proposals must coordinate with global platforms like ALZ-NET and include equity considerations 

💰 6. Budget Discipline & Indirect Costs Caps

Indirect costs limited to ≤10%; certain mechanisms (e.g., translational platforms) disallow indirects

Budgets should directly support the work plan and milestones .

🔄 7. Multi-Stage Peer-Review & Responsiveness

LOI stage determines eligibility for full proposal submission

Full proposals undergo multi-layered peer review, with final decisions by the Medical & Scientific Advisory Group 

Diversity-focused grants offer opportunity for resubmission with feedback 

🌐 8. Global Scope & Equity Focus

Programs target international collaboration, with emphasis on low- and middle-income country eligibility .

Calls like AARG-D are structured to broaden representation in dementia science .

📋 Summary Table

Predictor	Key Actions
Call alignment	Map aims to RFA priorities with precision
Innovation & rigor	Emphasize novelty, methodology, and feasibility
Team strength	Showcase expertise, collaborations, and ECI inclusion
Milestone-based planning	Provide clear yearly deliverables and timelines
Data sharing & openness	Include robust data plans and platform coordination
Budget compliance	Direct costs only; abide by indirect cost limits
Review-stage strategy	Prepare LOI, full proposal, and incorporate feedback
Equity & global inclusion	Engage diverse institutions, including LMICs and diversity grants

🛠 Pro Tips for Strong Applications

Start with a precise LOI—highlight innovation, alignment, and feasibility.

Map partners and platforms early for RWD/global calls.

Budget for data management and indirect limits accurately.

Build multi-stage proposals—LOI → full → revisions.

Engage diverse, global teams, especially for diversity and equity awards.

Leverage feedback from earlier attempts; resubmissions are allowed in some lines.

Specialties

Clinical Trials

Neurosciences

Eligibility Requirements

The VCID-UMD Grant Program is open to researchers at academic institutions and other non-profit research institutions. The Principal Investigator of the project must be a full-time faculty member (Assistant Professor, Instructor, Lecturer or higher) or full time paid employee of
the organization submitting the proposal. Applications from post-doctoral researchers will not be accepted, however, they can be included on applications as key personnel.

Investigators that have received Alzheimer’s Association funding and are currently delinquent in submitting required reports or have awards closed as “Incomplete” are not eligible to apply. For questions about eligibility, please contact the Alzheimer’s Association at grantsapp@alz.org.

Sponsor Details

Sponsor Institute/Organizations: Alzheimer's Association

Sponsor Type: Corporate/Non-Profit

Address: 225 N Michigan Ave. Floor 17 Chicago, IL 60601 800.272.3900

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