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Funding Opportunity




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ADDF-Harrington Scholar Program

Alzheimer's Drug Discovery Foundation

Average Award

The award typically entails up to $600,000 over 2 years with dedicated support for milestone-driven projects from a team of industry veterans with capabilities that include medicinal chemistry, pharmacology & toxicology, and business development. The expertise of each team is tailored to the specific needs of the project during the two-year award period.

DEADLINES

Letter of Intent: (Extended) June 9, 2025, 5:00 PM EDT
Full Proposal: August 18, 2025, 5:00 PM EDT

Award decisions are anticipated by March 2026.

Funding Priorities

Drug Targets
The 2026 ADDF-Harrington Scholar RFP places high priority on targets related to emerging therapeutic areas for dementia, particularly:

  • Proteostasis (including autophagy, lysosomal biogenesis, proteasomal degradation, post-translational modification associated with proteostasis, protein folding/misfolding, ER stress, extracellular clearance)
  • Senescence (including cells that have halted division, shifted towards a secretory phenotype, altered morphology and epigenetics, and decreased apoptosis)

AI Based Application Success Predictor

🎯 1. Alignment with ADDF’s Venture-Philanthropy Model

ADDF functions like a venture fund: when supporting academia, they expect a share in any commercial returns; with biotech, they may take equity, royalties, or convertible notes 

Demonstrate a clear commercial path—composition-of-matter IP or novel therapeutic modalities are prioritized 

🧪 2. Strong Scientific Rationale & Innovation

The Drug Development RFP targets IND-enabling studies and early-phase clinical trials (Phase 0–2a), especially for drugs with novel mechanisms—excluding traditional anti-amyloid or cholinesterase inhibitors 

Applicants must justify:

The novelty of the mechanism

Genetic or human biology support

Biomarker linkages and pathway to demonstrate target engagement

📅 3. Feasible, Milestone-Based Plan

Multi-year grants (up to max ~$5M) require IND-enabling studies (toxicology, GMP production) or early human trials with measurable biomarker and clinical endpoints 

Include well-structured milestones, timelines, and demonstrate ability to recruit subjects and engage biostatisticians early 

👥 4. Team Strength & Collaboration

ADDF looks for strong teams combining scientific, clinical, regulatory, and business expertise; partnerships with CROs are encouraged 

For biotechs, the business review board evaluates management, IP, and commercial viability 

💸 5. Budgeting & Cost Management

Only direct costs are allowed (e.g., personnel, consumables, small equipment ≤ $2.5K); no indirect costs

Grant amounts vary by stage; up to $5M is possible, but budget must align with milestones

🔁 6. Multi-Stage Review & Responsiveness

Process includes LOI → invited full proposal → iterative review by scientific and business panels 

Therapeutics applicants may resubmit up to two times addressing critiques point-by-point 

🔬 7. Support Beyond Funding

ADDF invests in non-financial support: expert guidance on preclinical/clinical strategy, regulatory affairs, partnership-building 

They also fund diagnostics accelerators, like the Biomarker Observatory, supporting blood, neuroimaging, and digital biomarker development 

✅ Summary Table

PredictorWhat to Do
Business alignmentShowcase IP/commercial path and readiness for venture-philanthropy model
Scientific novelty and rigorPropose a biomarker-supported, non-amyloid mechanism with strong evidence
Milestone-based feasibilityInclude clear, measurable research milestones and timelines
Collaborative team structureCombine scientific, clinical, regulatory, and business expertise
Direct-cost budgetingBuild precise budgets (no indirects or travel), aligned with milestones
Iterative submission planningPrepare LOI, full proposal, and be ready to resubmit based on ADDF feedback
Non-financial support utilizationLeverage mentorship, networking, and diagnostic platform resources

 

🚀 Pro Tips to Boost Your Proposal

Start with LOI clarity: define the novel mechanism, target, biomarkers, and scale.

Line up partnerships: include CROs or biotech collaborators early.

Detail your clinical/IND plan: incorporate biostatistics, subject recruitment, regulatory path.

Budget for milestones: base funding tranches on deliverables.

Engage with ADDF: reach out if your project fits the RFP or needs feedback.

Plan resubmissions: prepare to refine based on board input.

  • Academic investigators at accredited medical centers, research institutions, and universities in the United States, Canada and United Kingdom only are eligible to apply.
  • Lead investigator must have an MD, a PhD, or equivalent.
  • Proposals should show potential to advance discovery into meaningful therapeutics to treat, prevent, slow, or reverse Alzheimer’s disease or related dementias (vascular dementia, frontotemporal dementia, Lewy Body dementia, LATE etc).
  • Team should possess intellectual property (IP) or have potential for novel IP that has not yet been licensed to a for-profit entity.
  • Researchers working on drug development programs that are relevant to but not presently focused on the Alzheimer’s field are strongly encouraged to apply.

Eligible Countries:

Sponsor Institute/Organizations: Alzheimer's Drug Discovery Foundation

Sponsor Type: Corporate/Non-Profit

Address: 57 West 57th Street, Suite 904 New York, NY 10019 info@alzdiscovery.org 212.901.8000

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Grant

Final Deadline:

Aug 18, 2025

Funding Amount:

$600,000

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