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American Brain Foundation’s Cure One, Cure Many Award in Neuroinflammation

American Brain Foundation

Important Dates

• Pre-Proposals Accepted: June 2, 2025

• Pre-Proposals Due: July 15, 2025

• Invitations to Submit Full Applications Issued: August 2025

• Full Applications Due: September 30, 2025

• Anticipated Award Announcement: November 2025

• Anticipated Award and Funding Start: January 15, 2026

Program Description Neuroinflammation contributes to numerous diseases across all stages of life, from fetal development to aging. It plays a central role in neurological conditions ranging from Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, ALS, encephalitis, Huntington’s disease, stroke, brain tumor, epilepsy, migraine, chronic pain, myopathy and neuropathy, traumatic brain injury, meningitis, and COVID-19 associated brain disease.

Emerging insights into the disease-associated and neuroprotective/neuro-regenerative roles of neuroinflammation create extraordinary opportunities to harness the immune system’s potential to treat, repair, and even cure some of the most pernicious brain disorders, and to extend the healthy lifespan.

The 2025 Cure One, Cure Many Award in Neuroinflammation will be carried out through two types of grants: Breakthrough Grants and Catalyst Grants. Both types of grants support high-risk, high reward and translational research with a focus on clinical impact.

These grants are funded in collaboration with Encephalitis International (encephalitis.info), Gates Ventures, Genentech (gene.com), National Multiple Sclerosis Society (nationalmssociety.org), NFL Players Association (nflpa.com), and WoodNext Foundation (woodnext.org). Applications will be managed by the American Academy of Neurology (aan.com).

Funding Available A total of at least $5.4M is available through this call. The ABF intends to award:

• Two Breakthrough Grants of up to US $2 million each (up to $1 million per year for two years)

• At least two Catalyst Grants of up to US $500,000 (up to $250,000 per year for two years)

The Selection Committee reserves the right to award a lesser amount if the full request funding is deemed unjustified, or to fund additional applications should funds allow. Final budgets will be determined based on a review of proposed work.

Applicants are encouraged to leverage additional sources of funding and resources.

AI Based Application Success Predictor

🎯 1. Eligibility & Targeted Career Stage

Applicants must be AAN members with an MD, PhD, or equivalent, and have completed residency or PhD within the last 5 years before the award start date

The foundation supports early-career clinician-scientists, with scholarships covering 2 years including protected research time and educational support

🔬 2. Hypothesis-Driven & Clinically-Focused Research

Projects must be patient-oriented clinical or translational neurology studies, including epidemiologic, behavioral, interventional, mechanistic, or diagnostic tool development

Applications are evaluated on research quality, originality, feasibility, and clinical relevance

🧩 3. Strong Institutional Support & Mentorship

A named primary mentor with protected research time is mandatory.

Letters must confirm departmental and institutional commitment, including adequate research environment

📈 4. Track Record & Promise

Successful applicants demonstrate a track record of achievement (publications, abstracts).

Reviewers look for applicants who show career potential and drive as emerging neurologist-scientists .

💵 5. Budget & Timeline Clarity

CRTS awards typically provide $65K/year plus $10K/year in education/research costs, over two years (total ≈$150K) .

Budgets must be realistic, itemized, and aligned with your proposed timeline and project aims.

🏆 6. Comprehensive, Competitive Application

Review criteria include research plan quality, applicant credentials, mentorship, innovation, and project significance

Applications must be complete and submitted by the deadline (typically September 9 for CRTS) .

📋 Summary Table

Predictor	What It Requires
Eligibility	MD/PhD within 5 years + AAN membership
Research Focus	Patient-oriented, translational neurology
Mentorship & Support	Strong mentor and institutional backing
Applicant Credentials	Solid publication record and promise
Budget & Timeline Clarity	Realistic itemization for 2-year award
Application Completeness	All materials on time, formatted properly
Innovative & Significant Plan	Clear hypothesis, methods, and clinical impact

🛠 Pro Tips

Engage your mentor early to define a structured training and research plan.

Clarify your hypothesis and methods, including detailed stats and clinical relevance.

Obtain department chair confirmation for protected time and environment.

Design a coherent 2-year timeline with realistic budget and milestones.

Highlight your track record and long-term neurology research goals.

Polish all application documents, ensuring alignment with review criteria.

Submit early, allowing time for mentor/chair letters and budget checks.

Specialties

Neurosciences

Eligibility Requirements

Applications may be submitted by basic, translational, or clinical investigators from:

• U.S. and international public and private non-profit entities, such as universities, colleges, hospitals, and laboratories.

• U.S. and international biotechnology/pharmaceutical companies, or other publicly or privately held for-profit entities.

The principal investigator should hold an MD, PhD, or equivalent terminal clinical degree.

Sponsor Details

Sponsor Institute/Organizations: American Brain Foundation

Sponsor Type: Corporate/Non-Profit

Address: 201 Chicago Ave, Minneapolis, MN 55415

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