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American Brain Foundation’s Cure One, Cure Many Award in Lewy Body Dementia

American Brain Foundation

Important Dates

• Pre-Proposals Accepted: June 2, 2025

• Pre-Proposals Due: July 15, 2025

• Invitations to Submit Full Applications Issued: August 2025

• Full Applications Due: September 30, 2025

• Anticipated Award Announcement: November 2025

• Anticipated Award and Funding Start: January 15, 2026

Program Description

Lewy Body Dementia (LBD) is the second most common progressive dementia after Alzheimer’s disease (AD) and affects millions of individuals worldwide. When an individual presents with cognitive impairment, however, there are virtually no tools available to enable a clinician to make an accurate diagnosis of LBD.

Particularly for AD, molecular biomarkers as identified with positron emission tomography imaging agents, and potentially assays of Alzheimer proteins in the cerebrospinal fluid and blood may provide helpful evidence to support or refute the clinical diagnosis of the illness. However, biomarkers to aid in the clinical detection of dementia attributable to LBD are currently lacking. The lack of validated biomarkers for LBD contributes to delayed diagnosis and misdiagnosis, and thus potentially exposes individuals affected by LBD to inappropriate medication use and results in the failure to treat LBD-specific manifestations. The absence of biomarkers also impedes pertinent clinical and translational research, including drug and biomarker discovery efforts.

In collaboration with the American Academy of Neurology (AAN), Alzheimer’s Association (alz.org), and the Michael J. Fox Foundation for Parkinson’s Research (mjff.org), the American Brain Foundation (ABF) now seeks applications aimed for discovery, validation, and acceleration of LBD-related biomarkers.

The first Cure One, Cure Many Award in 2022 was granted to Drs. Owen A. Ross, Pamela J. McLean, and Bradley F. Boeve for their research on identifying biomarkers for LBD. Their work focuses on advancing diagnostic approaches for LBD, with an emphasis on early detection through molecular and imaging biomarkers.

Funding Available

The ABF intends to award a single grant of up to US $2 million for a budget period of up to 2 years. The Review Committee, however, reserves the right to award a lesser amount to an application if the full $2 million is deemed to be unjustified and/or to fund an additional application should funds allow.

Final budgets will be determined based on a review of proposed work. Academic and nonprofit institutions are allowed to allocate up to 15% of the total award amount to indirect costs. No additional indirect costs will be allowed. Applicants are encouraged to leverage additional sources of funding and resources.

AI Based Application Success Predictor

🎯 1. Eligibility & Targeted Career Stage

Applicants must be AAN members with an MD, PhD, or equivalent, and have completed residency or PhD within the last 5 years before the award start date

The foundation supports early-career clinician-scientists, with scholarships covering 2 years including protected research time and educational support

🔬 2. Hypothesis-Driven & Clinically-Focused Research

Projects must be patient-oriented clinical or translational neurology studies, including epidemiologic, behavioral, interventional, mechanistic, or diagnostic tool development

Applications are evaluated on research quality, originality, feasibility, and clinical relevance

🧩 3. Strong Institutional Support & Mentorship

A named primary mentor with protected research time is mandatory.

Letters must confirm departmental and institutional commitment, including adequate research environment

📈 4. Track Record & Promise

Successful applicants demonstrate a track record of achievement (publications, abstracts).

Reviewers look for applicants who show career potential and drive as emerging neurologist-scientists .

💵 5. Budget & Timeline Clarity

CRTS awards typically provide $65K/year plus $10K/year in education/research costs, over two years (total ≈$150K) .

Budgets must be realistic, itemized, and aligned with your proposed timeline and project aims.

🏆 6. Comprehensive, Competitive Application

Review criteria include research plan quality, applicant credentials, mentorship, innovation, and project significance

Applications must be complete and submitted by the deadline (typically September 9 for CRTS) .

📋 Summary Table

Predictor	What It Requires
Eligibility	MD/PhD within 5 years + AAN membership
Research Focus	Patient-oriented, translational neurology
Mentorship & Support	Strong mentor and institutional backing
Applicant Credentials	Solid publication record and promise
Budget & Timeline Clarity	Realistic itemization for 2-year award
Application Completeness	All materials on time, formatted properly
Innovative & Significant Plan	Clear hypothesis, methods, and clinical impact

🛠 Pro Tips

Engage your mentor early to define a structured training and research plan.

Clarify your hypothesis and methods, including detailed stats and clinical relevance.

Obtain department chair confirmation for protected time and environment.

Design a coherent 2-year timeline with realistic budget and milestones.

Highlight your track record and long-term neurology research goals.

Polish all application documents, ensuring alignment with review criteria.

Submit early, allowing time for mentor/chair letters and budget checks.

Specialties

Neurosciences

Eligibility Requirements

Applications may be submitted by basic, translational, or clinical investigators from:

• U.S. and international public and private non-profit entities, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government; and

• U.S. and international biotechnology/pharmaceutical companies, or other publicly or privately held for-profit entities.

Past awardees are eligible to apply for this funding.

Sponsor Details

Sponsor Institute/Organizations: American Brain Foundation

Sponsor Type: Corporate/Non-Profit

Address: 201 Chicago Ave, Minneapolis, MN 55415

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