Trialect

Active

Experimental Neurology

School of Medicine and Surgery,

University of Milano-Bicocca

Main Areas of Interest

Experimental Neurology

Workplace: Experimental Neurology Unit, School of Medicine, University of Milano-Bicocca, Monza,
Milano, Italy.

The main research areas of our group are:

Chemotherapy-induced peripheral neuropathy and neuropathic pain: in vivo, in silico, ex vivo and in vitro platforms to study pathogenetic mechanisms and protective strategies.
Innovative drug delivery for oncology, neuroimmunology and neuroprotection: in vitro, in silico and in vivo studies to test nanoparticles for their toxicity and effectiveness.
Restorative medicine: mesenchymal stem cells as therapeutic options for diabetes, multiple sclerosis,and chemotherapy-induced peripheral neuropathy.
Multiple sclerosis: identification of possible disease biomarkers in collaboration with the Neuroimmunology Center at the S. Gerardo Hospital in Monza.
Natural compounds as antineoplastic agents: in vitro evaluation of antitumoral effect of natural compounds total extracts and their subfractions on different tumoral cell lines

Techniques You Will Learn

Experimental platforms/techniques you will learn during your program here:

Platforms for in vitro studies

Organotypic dorsal root ganglia cultures
Primary neuronal and glial cell cultures (adult and embryonal)
Murine and human cancer cell cultures
Mesenchymal stem cells cultures
Co-cultures of Mesenchymal stem cells and sensory neurons
Patient–derived glioma stem cells

In vitro assays

Cell culture establishment and maintenance
Cell transfection
Cell viability/toxicity assays
Cell migration
Main molecular biology techniques (DNA, RNA and protein extracts; immunoblotting to study
molecular pathways)
Neurosphere formation and Limiting dilution assay
Evaluation of proteasome inhibitors activity
Apotosis and autophagy evaluation

Platforms for in vivo studies

Certified animal housing facility for Immunocompetent/immunodeficient animals
Animal models of chemotherapy-induced peripheral neuropathy and pain
Oncological models for melanoma, colon-cancer.

In vivo assays

Behavioral testing
Nerve conduction studies
Axonal hyperexcitability studies
Tomography for in vivo imaging
Blood chemistry and hematology

Platform for morpho-functional studies

Light, electron, confocal laser microscopy
Video-lapse microscopy
Immunohistochemistry, immunolabelling, immunofluorescence on 2D and 3D samples

Other platforms

Flow cytometry
Real Time-PCR
Immunoblotting
ELISA
In silico analysis
Use of Synchrotron Radiation to enhance anticancer drugs effectiveness in collaboration with European facilities

Curriculum

6-8 weeks curriculum

The trainee will be provided with the opportunity of learning the basis of preclinical research in the field of peripheral neuropathy, having experiences of facing with clinical staff (neurologists) and basic researchers in an interdisciplinary and translational research environment
The trainee will be provided with the unique opportunity of experiencing the laboratory practice and to operate trainings on molecular biology, biochemistry, morphology, and neuropathology
The trainee may also have the opportunity of collaborating on research projects, depending on the ongoing activities at the time of the Trainee’s visit
The trainee will be provided with the opportunity of evaluating alternative antineoplastic agents for “Orphan Tumors”
The trainee will be provided with the opportunity of participating to meetings, journal clubs,seminars, including those of the PhD in Neuroscience and Virgilio Program at Experimental Neurology Unit and UNIMIB
The trainee will have the opportunity to join collaborative research programs with national and international laboratories and companies ongoing at Experimental Neurology Unit at the time of the Trainee’s visit
Please visit the websites below for more informations: https://www.enu.dcmt.unimib.it/
https://en.unimib.it/education/doctoral-research-phd-programmes/phdprogrammes/neuroscience
https://virgilioprogram.unimib.it/

Accommodation

Residence Luna

website (Italian; possible online reservation): https://www.residencelunadimonza.it/
website (English; possible online reservation): https://www.onlinereservations.com/?hotelid=1473933&gclid=CjwKCAjw4qCKBhAVEiwAkTYsPIcTkPVKr1mNoe377rtedHOawqpOe1HUI1YK6Sc_Y2FWbry-Mq8ESxoCGUkQAvD_BwE

Helios Hotel

website (Italian; possible online reservation): https://heliosmonza.com/it/
website (English; possible online reservation): https://heliosmonza.com/en/

Residenze Universitarie Bicocca

website (Italian; possible online reservation): https://bicocca.residenzesodexo.it/
website (English; possible online reservation): https://en.unimib.it/services/bicoccacampus/accommodation

Campus in-domus

website (Italian; possible online reservation): https://www.indomus.it/
website (English; possible online reservation): https://www.indomus.it/en/

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.

Who Can Apply

All are eligible

Host Details

Host Name: Prof. Guido Cavaletti

Affiliation: School of Medicine and Surgery,

Address: University of Milano-Bicocca, Piazza dell'Ateneo Nuovo; 1, 20126 Milano MI; Italy

Website URL: https://en.unimib.it/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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Onsite/On-Campus Program

Fellowship - Basic/Translational/Clinical Research Program

Italy

Application Review Deadline:

Jan 1st, 2024

Apply Now

Program Logistics and Administrative Fees

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

Questions and Answers

Commonly asked questions about this program from the host and other attendees.

Do I get any fellowship? If yes than how much?

No. Please go through the Understand Your Category section on the posting.

Is the period of the programe flexible or fixed?

You have a flexible schedule to work with the host mentor and pick a suitable time for you and the host.

Can I cancel my application when I will be accepted for priority or sponsored categories but not for a Merit one?

Yes

What do you mean by letter if intent?

You will see several representative samples online to draft a letter of intent. Your letter of intent has to be very precise, describing your capabilities and interests, and at the same time clearly defining your goals.