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Cerebral Amyloid Angiopathy (CAA) and Alzheimer Disease (AD) Translational Research

School of Medicine and Surgery, University of Milano-Bicocca

University of Milano Bicocca

Main Areas of Interest

Cerebral Amyloid Angiopathy (CAA) and Alzheimer Disease (AD) Translational Research

Workplace: Laboratory of CAA and AD Translational Research and Biomarkers, School of Medicine,University of Milano-Bicocca, Monza, Milano, Italy.

The main research areas of our group are:

Cerebral Amyloid Angiopathy (CAA) and CAA-related inflammation (CAA-ri)

Wet biomarkers discovery & validation of neuroinflammation, endothelial damage, anti-amyloid auto-antibodies (cerebrospinal fluid and plasma)
Imaging biomarkers (MRI) of WMHs, cerebral haemorrhage (cMBS, cSS), brain swelling

Spontaneous Amyloid-related Imaging Abnormalities (ARIA) and iatrogenic-ARIA side effects of immunotherapy with monoclonal antibodies drug targeting amyloid-deposited protein of
Alzheimer’s disease (AD)

Anti-amyloid dosage for diagnostic, prognostic, theranostic monitoring and drug target engagement and effectiveness
MRI hallmarks of ARIA-E and ARIA-H, MRI markers of CAA-ri and spontaneous CAA.

Techniques You Will Learn

Experimental techniques/Technical approaches you will learn during your program here:

Educational classes and seminars on CAA-ri and ARIA, including disease mechanisms, risk factors, diagnosis, treatment
Deep learning activities for data interpretation in diagnosis recognition, prognosis and clinical-therapeutic monitoring at follow-up (CSF, MRI, clinical, therapy)
Cross sectional and longitudinal analyses of large International and national datasets/samples of the iCAB International Cohort Registry & Biobank
(https://sites.google.com/site/icabinternationalnetwork)
In-person stage in the CAA and AD Biomarkers Laboratory, including the set-up of the anti-Abeta autoantibody test.
In-person practice activities for the recognition and diagnosis of MRI images of ARIA and CAA-ri with real-life cases referred to the iCAB Network.
Team working activities with Laboratory Researchers, Neurologists and Neuroradiologist

Curriculum

6-12 weeks curriculum

The trainee will be provided with the opportunity of deeply understand the theoretical and practical activities needed for the diagnosis, disease monitoring and treatment of rare but increasingly emerging neurological conditions, namely CAA, CAA-ri, and ARIA side effects of immunotherapy of AD
The trainee will be provided with the unique opportunity to experience the Laboratory practice and to operate trainings on the innovative methods for CSF autoantibody test for CAA-ri and ARIA
The trainee will operate in an interdisciplinary and translational research environment, including meetings and in-person activities with basic scientists, neurologists, and neuroradiologist experts
The trainee will be provided with the unique Networking opportunities in the field of CAA-ri and ARIA
The trainee will also be provided with teaching classes and seminars provided by the School of Medicine, including the Neuroscience PhD program activities, and by the iCAB International
Collaborators:
The iCAB International Network https://sites.google.com/site/icabinternationalnetwork
PhD School in Neuroscience https://en.unimib.it/education/doctoral-research-phd-programmes/phdprogrammes/neuroscience
Virgilio Program, a pre-graduate training track in biomedical research https://virgilioprogram.unimib.it/
The trainee may also have the opportunity to collaborate on research projects, depending on the ongoing activities at the time of the Trainee visit.

Accommodation

Residence Luna

website (Italian; possible online reservation): https://www.residencelunadimonza.it/
website (English; possible online reservation): https://www.onlinereservations.com/?hotelid=1473933&gclid=CjwKCAjw4qCKBhAVEiwAkTYsPIcTkPVKr1mNoe377rtedHOawqpOe1HUI1YK6Sc_Y2FWbry-Mq8ESxoCGUkQAvD_BwE

Helios Hotel

website (Italian; possible online reservation): https://heliosmonza.com/it/
website (English; possible online reservation): https://heliosmonza.com/en/

Residenze Universitarie Bicocca

website (Italian; possible online reservation): https://bicocca.residenzesodexo.it/
website (English; possible online reservation): https://en.unimib.it/services/bicoccacampus/accommodation

Campus in-domus

website (Italian; possible online reservation): https://www.indomus.it/
website (English; possible online reservation): https://www.indomus.it/en/

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.

Who Can Apply

All are eligible

Host Details

Host Name: Prof. Fabrizio Piazza

Affiliation: School of Medicine and Surgery, University of Milano-Bicocca

Address: Piazza dell'Ateneo Nuovo; 1, 20126 Milano MI; Italy

Website URL: https://en.unimib.it/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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