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Toxic Exposures Research Program Clinical Trial Partnership Award

Congressionally Directed Medical Research Programs

Summary: The intent of the FY25 Toxic Exposures Research Program (TERP) Clinical Trial Partnership Award (CTPA) is to support new or existing collaborative partnerships that will rapidly implement clinical trials with the potential to have a significant impact on the prevention, treatment or management of symptoms, diseases, or conditions associated with or resulting from military-related toxic exposures. Proposed projects may range from small proof-of-concept clinical trials (e.g., pilot, first-in-human, phase 0) designed to demonstrate the feasibility or inform the design of more advanced trials through large-scale trials (including pragmatic clinical trials) to determine efficacy in relevant patient populations.

Distinctive Features: To encourage applications that include meaningful and productive collaborations between investigators, the FY25 TERP CTPA requires partnership of the Initiating Principal Investigator (PI) with at least one, and up to two, other collaborating PIs for the completion of one overarching study.

Funding Details: The CDMRP expects to allot approximately $4.2 million (M) to fund approximately one Clinical Trial Partnership Award application with a total cost cap of $4.2M. The maximum period of performance is 4 years. It is anticipated that the award made from this FY25 funding opportunity will be funded with FY25 funds, which will expire for use on September 30, 2031. Awards supported with FY25 funds will be made no later than September 30, 2026.

AI Based Application Success Predictor

🎯 1. High-Risk, High-Gain & Patient‑Relevant Science

CDMRP intentionally funds innovative, paradigm‑shifting research across the full pipeline—from basic discovery to clinical trials—that addresses critical gaps in health outcomes for service members and the public .

🤝 2. Strong Interdisciplinary & Multi-Investigator Teams

Team‑science mechanisms (e.g., Synergistic Idea Awards) require multiple PIs—each funded independently—not sub-awards, encouraging true synergy across disciplines and institutions .

🔁 3. Two‑Tier Review Incorporating Consumer Input

Tier 1: Peer review assesses technical merit.

Tier 2: Programmatic review weighs scientific excellence alongside program relevance, portfolio balance, and consumer advocate perspectives—consumers have equal voting power  .

🌱 4. Career Development Support for Emerging Researchers

CDMRP includes nested awards for predoctoral, postdoctoral, and clinician-scientist candidates, with programs like the Ovarian Cancer Academy offering mentoring, networking, and skill-building  .

🧭 5. Alignment with Congressional Priorities & Program Missions

Each program is guided by yearly appropriations and congressional mandate. Success depends on tightly aligning proposals with specific program objectives and anticipated topics  .

🗓️ 6. Timely Preparation Amid Short, Dynamic RFA Windows

RFAs are brief and often come with 30–60 days lead time. Staying alert to pre-announcements, registering in eBRAP and Grants.gov, and planning early are essential  .

📊 7. Avoiding Duplication Through Informed Coordination

CDMRP actively coordinates with NIH and VA to prevent redundant funding. Before submitting, check existing programs and anticipate strategic adjustments to your proposal if overlap is flagged .

📈 Summary—What You Need to Do

Core Factor	Why It Matters
Bold, high‑impact science	CDMRP rewards innovation and high risk
Team/consortia readiness	Mechanisms favor multi‑PI, multi-institution studies
Consumer inclusion	Proposals must speak to patient relevance and include advocates
Mentoring and training plan	Especially for early- and mid-career awards
Strict alignment with program scope	Tailor aims to each RFA and congressional intent
Rapid response capability	Be ready to mobilize within 1–2 months
Portfolio awareness & distinctiveness	Show how your proposal complements—not duplicates—other programs

💡 Winning Tips

Track pre-announcements—sign up for CDMRP alerts and maintain your eBRAP profile.

Review recent funded summaries—understand what CDMRP programs value and shape your proposal accordingly.

Plan and build consortia early—ensure collaborators are involved from concept development to submission.

Engage consumer advocates—integrate patient or stakeholder perspectives in your aims and review process.

Check overlap and coordinate—avoid redundancy with NIH/VA programs; emphasize unique CDMRP-relevant aspects.

Prepare for fast turnarounds—have draft aims, compliant budgets, and institutional approvals ready to go.

Leverage nested training/career awards—if eligible, use them to build capacity and complement your full proposal.

🔧 Final Thought

CDMRP funding favors bold, multidisciplinary teams tackling high-priority challenges with consumer engagement, aligned to congressional mandates, and ready for rapid deployment. Proposals that demonstrate these qualities—and address career development—are strongly positioned to win.

Specialties

Clinical Trials

Eligibility Requirements

2.1.1. Organization Extramural and intramural organizations are eligible to apply, including foreign and domestic organizations, for-profit and non-profit organizations, and public or private entities.

Extramural Organization: An eligible non-Department of Defense (DOD) organization. Examples of extramural organizations include academic institutions, biotechnology companies, foundations, federal government organizations other than the DOD (i.e., intragovernmental organizations), and research institutes.

Intramural DOD Organization: Refers specifically to DOD organizations including DOD laboratories, DOD military treatment facilities, and/or DOD activities embedded within a civilian medical center.

2.1.2. Principal Investigator

Independent investigators at all career levels may be named by their organizations as the Initiating PI or Partnering PI(s) on the application. Individuals in a mentored position (e.g. postdoctoral fellows, clinical fellow) are not considered independent investigators. Applicants are discouraged from being named as a Partnering PI on multiple applications unless they are clearly addressing distinct research questions. Individuals affiliated with an eligible organization are eligible to be named as PI regardless of ethnicity, nationality, or citizenship status.

Sponsor Details

Sponsor Institute/Organizations: Congressionally Directed Medical Research Programs

Sponsor Type: Corporate/Non-Profit

Address: 1077 Patchel Street Fort Detrick, MD 21702-5024 Phone: (301) 619-7071

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