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Funding Opportunity




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Mathematical Foundations of Artificial Intelligence

U.S. National Science Foundation (NSF)

Program Title:

Mathematical Foundations of Artificial Intelligence (MFAI)

Synopsis of Program:

Machine Learning and Artificial Intelligence (AI) are enabling extraordinary scientific breakthroughs in fields ranging from protein folding, natural language processing, drug synthesis, and recommender systems to the discovery of novel engineering materials and products. These achievements lie at the confluence of mathematics, statistics, engineering and computer science, yet a clear explanation of the remarkable power and also the limitations of such AI systems has eluded scientists from all disciplines. Critical foundational gaps remain that, if not properly addressed, will soon limit advances in machine learning, curbing progress in artificial intelligence. It appears increasingly unlikely that these critical gaps can be surmounted with increased computational power and experimentation alone. Deeper mathematical understanding is essential to ensuring that AI can be harnessed to meet the future needs of society and enable broad scientific discovery, while forestalling the unintended consequences of a disruptive technology.

The National Science Foundation Directorates for Mathematical and Physical Sciences (MPS), Computer and Information Science and Engineering (CISE), Engineering (ENG), and Social, Behavioral and Economic Sciences (SBE) will jointly sponsor research collaborations consisting of mathematicians, statisticians, computer scientists, engineers, and social and behavioral scientists focused on the mathematical and theoretical foundations of AI. Research activities should focus on the most challenging mathematical and theoretical questions aimed at understanding the capabilities, limitations, and emerging properties of AI methods as well as the development of novel, and mathematically grounded, design and analysis principles for the current and next generation of AI approaches.

Specific research goals include: establishing a fundamental mathematical understanding of the factors determining the capabilities and limitations of current and emerging generations of AI systems, including, but not limited to, foundation models, generative models, deep learning, statistical learning, federated learning, and other evolving paradigms; the development of mathematically grounded design and analysis principles for the current and next generations of AI systems; rigorous approaches for characterizing and validating machine learning algorithms and their predictions; research enabling provably reliable, translational, general-purpose AI systems and algorithms; encouragement of new collaborations in this interdisciplinary research community and between institutions.

The overall goal is to establish innovative and principled design and analysis approaches for AI technology using creative yet theoretically grounded mathematical and statistical frameworks, yielding explainable and interpretable models that can enable sustainable, socially responsible, and trustworthy AI.

Award Information

Anticipated Type of Award: Standard Grant or Continuing Grant

Estimated Number of Awards: 15

We anticipate making up to 15 awards in each competition. Each award size may vary and is expected to range from $500k to $1.5M total. Each award is expected to take place for a duration of 36 months. Award size is contingent upon the scope, scale and complexity of the proposed project. The number of awards will be subject to the availability of funds and quality of proposals received.

Anticipated Funding Amount: $8,500,000

Up to $8,500,000 per year is expected for new awards, subject to availability of funds and receipt of meritorious proposals.

Who May Submit Proposals:

Proposals may only be submitted by the following:

  • Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities.
  • Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members.

Who May Serve as PI:

As of the date the proposal is submitted, any PI, co-PI, or senior/key personnel must hold either:

  • a tenured or tenure-track position, or
  • a primary, full-time, paid appointment in a research or teaching position

at a US-based campus of an organization eligible to submit to this solicitation (see above), with exceptions granted for family or medical leave, as determined by the submitting organization. Individuals with primary appointments at for-profit non-academic organizations or at overseas branch campuses of U.S. institutions of higher education are not eligible.

Limit on Number of Proposals per Organization:

There are no restrictions or limits.

Limit on Number of Proposals per PI or co-PI: 1

A Principal Investigator (PI) or co-Principal Investigator (co-PI) can be part of no more than one proposal per deadline in response to this solicitation.

Sponsor Institute/Organizations: U.S. National Science Foundation (NSF)

Sponsor Type: Government/Federal

Address: 2415 Eisenhower Ave Alexandria, VA 22314 (703) 292-5111

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Grant

Letter Of Intent Deadline:

Oct 10, 2025

Final Deadline:

Oct 10, 2025

Funding Amount:

$8,500,000

15 awards available.

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