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Litwin IBD Pioneers

Crohn's & Colitis Foundation

The Litwin IBD Pioneers initiative, formerly known as the Broad Medical Research Program at the Crohn’s & Colitis Foundation, supports innovative clinical and translational research projects with the potential to impact the treatment of IBD patients in the near future. The program encourages novel research into the diagnosis, identification of clinically relevant subsets, treatments, and cures for inflammatory bowel diseases (IBD) and funds innovative pilot research so that scientists can test their initial ideas and generate preliminary data.

Litwin IBD Pioneers supports researchers who are exploring all possible opportunities for diagnostic and therapeutic improvements, including novel, out-of-the-box ideas, and funds innovative and pioneering ideas that have a clinically relevant focus. Additionally, the program is open to investigators from other disciplines new to the IBD field, as well as countries outside the United States.

How to Apply

Review guidelines (eligibility, budget, proposal components, etc.)
Visit Proposal Central - The Foundation uses the Proposal Central system for all grants submissions. If you are new user, create an account
Navigate to the "Grant Opportunities" tab (top right) Filter by grant maker (select "Crohn's & Colitis Foundation") to find the application link for Litwin IBD Pioneer. All instructions and policies are available at this site
Submit Letter of Intent by deadline

Submission Deadlines
Pre-Application	Portal Opens: October 4, 2025 Deadline: December 2, 2025 11:59pm EST
Online Application Submission	January 22, 2026 11:59pm EST
Applications Review	April – May
Decisions Announced	June

Application Phases

There is a two-step process for requesting funding for a Litwin IBD Pioneer award:

The first step is to submit a Letter of Interest on Proposal Central. Decisions on Letters of Interest are made within four to six weeks. If the decision falls after the deadline for submission of the full grant application, then the proposal will be reviewed in the subsequent review cycle.
If the LOI is accepted, an invitation is extended to submit a Full Grant Application. The Grant Application instructions can be found in the same instructions document as the Letter of Interest, located on Proposal Central. The schedule for grant application review and decision is listed below.

Budget Request

Funding can be requested for up to two years, but grants are funded only one year at a time. If a PI wishes to seek continuation funding, funding for a second year is based upon a satisfactory Competing Renewal Application that will undergo full committee peer review. If Year 1 milestones are met, please select the appropriate competing renewal deadline for Year 2 funding.
Budgets should be appropriate for the project's scope of work and resources necessary to complete the goals. All necessary costs for conduct of the study can be budgeted, including items such as personnel, supplies, equipment, publications costs, and travel. Awards are not funded above $130,000, including 10% indirect costs, for clinical trials; and not above $110,000, including 10% indirect costs, for lab-based studies.

Evaluation Criteria

Grant proposals are selected for funding based on their scientific strength, innovation, and relevance to IBD diagnosis, therapy or prevention. Preference is given to proposals for work conducted with patients or patient material and with strong potential for clinical applicability in the foreseeable future.

AI Based Application Success Predictor

Strong IBD Focus

Research must directly address Crohn’s disease or ulcerative colitis, aligned with CCF’s “Challenges in IBD Research” strategic roadmap.

Independent & Appropriate Career Stage

Student Fellowships for undergrad/grad/medical students with faculty mentorship .

Postdoctoral Fellowships for early post-PhD/MD researchers showing the need for training .

Career Development Awards target promising mid-stage investigators poised for independence .

Senior Research Awards support established investigators to build pilot data for major funding like NIH 

Mentorship & Institutional Support

Fellowships require a formal mentoring plan and student awards require a non-relative faculty mentor 

Senior and career awardees must be fully independent and affiliated with eligible institutions (non-profit/public/government) .

Competitive Funding & Budget Compliance

Budgets vary by award:

Student: up to $2.5K 

Fellowship: up to $70K/year 

Senior: up to $130K/year with direct and capped indirect costs .

Funding cycles typically follow LOI → full proposal stages with strict submission through proposalCENTRAL or Flexigrant .

Strategic Alignment & Innovation Focus

Proposals should address high-impact questions outlined in the foundation’s Challenges in IBD report, such as precision medicine, environmental triggers, novel technologies, and translational or pragmatic clinical research .

Access to Resources & Data

Senior awardees can leverage IBD Plexus biosamples and datasets to boost data quality and justification .

Rigorous Peer Review & Reporting

Applications are reviewed by panels of scientists, clinicians, and people with IBD

Funded grants require annual progress reports and long-term impact tracking (via Researchfish®).

Publications must acknowledge Foundation support and inventions reported.

📝 Summary Table

Award Category	Success Factors
Student Fellowship	Direct IBD relevance; strong mentor; full-time commitment.
Postdoctoral Fellowship	Focused training in IBD; mentor plan; legal work status in U.S.
Career Development	Mid-career readiness; mentor support; address career gaps.
Senior Research Award	Established independence; IBD-focus; institutional support; IBD Plexus integration.

🚀 Tips to Strengthen Your Application

Align with IBD Challenges report—situate your proposal within CCF priority areas.

Choose the right award—match your career stage and independence level.

Secure mentor & institutional backing early—include commitment letters.

Plan your budget carefully—follow limits and institutional roles.

Utilize CCF resources—like IBD Plexus sample/data for senior-level applicants .

Craft a compelling LOI to earn an invitation to the full proposal.

Prepare for reporting expectations—progress reports, publications, impact data tracking.

Specialties

Clinical Trials

Eligibility Requirements

Applicant Eligibility

The applicant institution must be a non-profit, charitable institution, such as a university, hospital, or research organization. Applications are accepted from institutions worldwide
The applicant who wishes to take on the Principal Investigator position must have a faculty appointment at the institution. For this, we request that the applicant's university or institution (particularly the Grants and Contracts personnel) send us a statement confirming that the applicant is or is not able to apply as a Principal Investigator from his/her institution
There can be only one Principal Investigator for each proposal

Proposal Eligibility

Proposal must be relevant to IBD, which includes Crohn's disease and/or ulcerative colitis
Only one application is allowed per applicant per submission date
Simultaneous submission of the same application for other awards is not permitted

Sponsor Details

Sponsor Institute/Organizations: Crohn's & Colitis Foundation

Sponsor Type: Corporate/Non-Profit

Address: 733 THIRD AVENUE, SUITE 510, NEW YORK, NY 10017

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