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ISHLT Cardiogenic Shock Research Grant

International Society for Heart and Lung Transplantation

This grant will fund research that focuses on any or all of these areas:

Early identification of patients with heart failure cardiogenic shock, best practices for device selection and escalation, and/or weaning strategies (Cardiogenic Shock)
Criteria for the use of tMCS to optimize outcomes and promote heart recovery, including patient management, combined therapies, and mechanistic understanding (Heart Recovery)
Artificial intelligence, machine learning, and data science to develop predictive modeling for native heart recovery in patients on tMCS (Predictive Modeling)

This grant is aimed at supporting rising stars who are experienced with the use of tMCS for cardiogenic shock. The grant recipient(s) will have already established a track record in cardiogenic shock and will aim to further develop their career(s) in this area.

The intent is that the grant recipient(s) will be junior faculty who has not previously received a major grant, and is dedicated to a career in the use of MCS to optimize outcomes in cardiogenic shock. It is anticipated that the individual will be a clinician/clinician scientist (physician, allied health or nurse) at an active cardiogenic shock program with a faculty appointment in either cardiology, critical care, or cardiac surgery.

Purpose

The purpose of this grant is to support research that would enhance the understanding and management of cardiogenic shock in the setting of heart failure to optimize clinical outcomes and promote native heart recovery using temporary mechanical circulatory support (tMCS).

Grant Details

One or more grants will be awarded for the funding duration of two years at a budget of up to $140,000 USD.

AI Based Application Success Predictor

1. Early-Career Investigator Status with Track Record

Most grants target rising stars — junior faculty who have completed training within 3 years (for Career Development) or have begun their faculty position before grant start.

Applicants must demonstrate previous work in heart and/or lung transplantation, mechanical support, or heart failure .

🏥 2. Strong Institutional Affiliation & Resources

Eligible applicants must have an academic appointment at an accredited institution and demonstrate institutional support, such as lab space, faculty appointment letters (if still in training), and departmental backing .

📝 3. Active ISHLT Membership

Consistent membership in ISHLT is required throughout the application and funding period .

🧪 4. Innovation & Relevance to Advanced Heart/Lung Care

Grants emphasize critical areas like mechanical circulatory support (MCS), transplantation, ICU care, biomarkers, AI tools, and biomarker validation .

Innovation challenge grants favor novel technologies—e.g., noninvasive dd-cfDNA, AI-based profiling, ex vivo lung perfusion.

🎯 5. Feasible Plan & Translational Potential

Projects should be well-scoped with a realistic timeline, aiming to substantially impact clinical practice within 1–5 years .

Feasibility, including clear methodology and data endpoints, is critical .

💰 6. Budget Adherence & Proper Cost Allocation

ISHLT grants typically cover salary, supplies, statistical support, with strict limits (e.g., indirect costs ≤10%, no excessive overhead or equipment budgets).

Funding is phased with milestones—e.g., Career Development grants disburse quarterly tied to reports .

🧑‍🔬 7. Peer Review Emphasizing Scientific Merit

Applications are evaluated by expert committees scoring aims, significance, innovation, approach, feasibility, and investigators’ track record .

✅ Key Strategies for a Winning Application

Factor	What to Emphasize
Early-career status	Position yourself as a rising faculty with a focused research trajectory.
Institutional support	Include faculty appointment, support letters, and resource descriptions.
ISHLT engagement	Maintain active membership and participation.
Clinical/scientific salience	Center on transplantation, MCS, biomarkers, AI, or cardiogenic shock.
Methodological soundness	Clearly outline study design, endpoints, and realistic timelines.
Budget discipline	Request only permitted expenses; follow funding structure and reporting schedule.
Strong presentation	Craft clear, concise aims; highlight innovation and capacity to deliver results.

🔁 Final Thoughts

To maximize your competitiveness, present yourself as a well-prepared early-career faculty member with:

A focused, innovative project in priority ISHLT areas (transplantation, MCS, biomarkers, AI).

Institutional backing through faculty appointment and resources.

ISHLT engagement and membership.

Sound methodology, realistic feasibility, and budgeting.

A scientific narrative ready for rigorous peer review.

Specialties

Pulmonology

Eligibility Requirements

Academic Appointment and Institutional Resources

The applicant must either have an academic appointment or clinical appointment or may be in training at an accredited institution.
An individual who applies for a research grant while still in training must have been offered and accepted a faculty position that will begin on or before initiation of the grant OR submit a letter of institutional commitment from a division or department chair at the institution at which the research will be conducted, if still in training at initiation of the grant.

ISHLT Membership

The applicant must be an active member of ISHLT or have submitted a completed membership application by 30 September.

Previous ISHLT Funding/Funding from Other Sources

There are no restrictions on past or current funding.
- The applicant may be a past or current recipient of an ISHLT Fellowship or Faculty Development research grant.
- The applicant may currently hold career development awards, mentoring awards, or other independent research awards.
If the applicant is currently receiving funding for a project similar to the topics described in this request for applications, the applicant must explain how the funds of the grant would not overlap with the funds of the other research support.

Miscellaneous

Applicants who have a substantial relationship with Johnson & Johnson MedTech | Heart Recovery that would present a real or perceived conflict of interest if awarded this grant must first contact ISHLT to declare the conflict before submitting an application. Examples of a substantial relationship with an industry partner include: board member, member of advisory council, consultant, lecturer, etc.
- Employees of Johnston & Johnson MedTech | Heart Recovery cannot submit an application.
- Upon disclosure, the Grants and Awards Committee will determine if the individual is eligible to submit an application and will notify the individual in a timely manner.

Sponsor Details

Sponsor Institute/Organizations: International Society for Heart and Lung Transplantation

Sponsor Type: Corporate/Non-Profit

Address: 141 West Jackson Suite 1340 Chicago, IL 60604 USA

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