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Individual Investigator Research Awards for Prevention and Early Detection

Cancer Prevention and Research Institute of Texas

This RFA solicits clinical and population-based projects designed to improve current methods and develop new strategies for the prevention and early detection of cancer among Texans. Examples of projects responsive to this RFA include those planning clinical or population-based novel projects to do the following:

(1) To identify social, environmental, and behavioral factors, genetic markers, and health disparities that underlie cancer risk and predisposition among Texans at high risk for cancer.

(2) To validate biomarkers, genomic technologies, or imaging methods in populations at risk for cancer that will lead to detection of cancers at an early stage.

(3) To develop and validate innovative interventions for the prevention or early detection of cancers with particular emphasis on Texans at highest risk for cancer.

(4) To conduct behavioral science studies that inform the development of interventions to reduce cancer risk, eg, conducting obesity research, increasing uptake of screening or cancer vaccinations, or reducing use of combustible tobacco and vaping products, particularly in populations with cancer disparities.

(5) To increase implementation and/or dissemination of evidence-based interventions for the prevention and/or early detection of cancers among all Texans as well as those populations at high risk.

(6) To conduct health services research in populations at highest risk to identify the most effective ways to address the disparities (eg, through systems change, outreach, access) and delivery of early detection and preventive care.

(7) To conduct survivorship research to predict outcomes, to identify children and adolescents at risk of developing late effects of treatment, or to improve quality of life for survivors of childhood and adolescent cancers or caretakers of individuals with cancer.

(8) To conduct survivorship research on adults following a diagnosis of cancer, eg, the effects of cancer and its treatment on patients with other health conditions, health care utilization and access, and health equity, or the effects on caretakers.

Basic research using laboratory and/or animal models designed to identify underlying mechanisms causing cancer is not responsive to this RFA and should be directed to other CPRIT mechanisms supporting basic discovery research.

Basic and clinical research to discover or to evaluate chemoprevention strategies is not responsive to this RFA and should be directed to other CPRIT mechanisms supporting basic discovery research or clinical translational research.

Basic and clinical research to predict outcomes, to identify children and adolescents at risk of developing late effects of treatment or to improve quality of life for survivors of childhood and adolescent cancers is not responsive to this RFA and should be directed to other CPRIT mechanisms supporting research on cancer in children and adolescents.

Specialties

Cancer

Oncology

Eligibility Requirements

• The applicant must be a Texas-based entity. Any not-for-profit institution or organization that conducts research is eligible to apply for funding under this award mechanism. A public or private company is not eligible for funding under this award mechanism; these entities must use the appropriate award mechanism(s) under CPRIT’s Product Development Research Program.

• The PI must have a doctoral degree, including MD, PhD, DDS, DMD, DrPH, DO, DVM, or equivalent, and be a full-time resident of Texas during the time the research that is the subject of the grant is conducted.

• The PI must hold an appointment at the rank of assistant, associate or professor, tenure track or tenured (or equivalent), at an accredited academic institution, research institution, industry, government agency, or private foundation. The PI must also have appropriate designated laboratory or clinical space, or other facilities in which to conduct the proposed studies.

• This award mechanism allows MIs for projects that require a team science approach (see the IFA for guidelines on CPRIT rules for MI awards).

• For applications that include 1 PI, the PI is required to maintain a minimum of 15% level of effort through the duration of the entire award period. For applications that include MIs, each PI is required to maintain a minimum of 10% effort through the entire duration of the award period.

• A PI may not submit applications to this RFA and to RFA R-26.1-IIRA, RFA R-26.1- IIRACCA, RFA R-26.1-IIRACSBC, RFA R-26.1-IIRACT, or RFA R-26.1-IIRAEOC.

• A PI/MI may not submit more than 1 application, either a new, resubmission, or renewal application under this RFA during this funding cycle

• A PI may not be a part of more than one application, whether as a single applicant or as part of an MI on an application, under this RFA and RFA R-26.1-IIRA, RFA R-26.1- IIRACCA, RFA R-26.1-IIRACSBC, RFA R-26.1-IIRACT, or RFA R-26.1-IIRAEOC.

• An individual may serve as a PI on no more than 3 active CPRIT Academic Research grants. Recruitment grants and Research Training Awards do not count toward the 3- grant maximum; however, CPRIT considers MIRA Project MIs equivalent to a PI. For the purpose of calculating the number of active grants, CPRIT will consider the number of active grants at the time of the award contract effective date (for this cycle expected to be December 1, 2025).

• Applications that address basic or animal-based projects, cancers in children and adolescents, computational systems biology of cancer, or therapeutic clinical trials should be submitted under the appropriate targeted RFA. Note that a smoking cessation clinical trial using drugs, can fit under this RFA.

• Collaborating organizations may include public, not-for-profit, and for-profit entities. Such entities may be located outside of the State of Texas, but non-Texas-based organizations are not eligible to receive CPRIT funds.

• An applicant is eligible to receive a grant award only if the applicant certifies that the applicant institution or organization, including the PI, any senior member or key personnel listed on the grant application, or any officer or director of the grant applicant’s institution or organization (or any person related to 1 or more of these individuals within the second degree of consanguinity or affinity), has not made and will not make a contribution to CPRIT or to any foundation specifically created to benefit CPRIT.

• An applicant is not eligible to receive a CPRIT grant award if the applicant PI, any senior member, or key personnel listed on the grant application, or any officer or director of the grant applicant’s organization or institution is related to a CPRIT Oversight Committee member.

• The applicant must report whether the applicant institution or organization, the PI, or other individuals who contribute to the execution of the proposed project in a substantive, measurable way, regardless of whether those individuals are slated to receive salary or compensation under the grant award, are currently ineligible to receive federal grant funds or have had a grant terminated for cause within 5 years prior to the submission date of the grant application.

• CPRIT grants will be awarded by contract to successful applicants. Certain contractual requirements are mandated by Texas law or by administrative rules. Although applicants need not demonstrate the ability to comply with these contractual requirements at the time the application is submitted, applicants should make themselves aware of these standards before submitting a grant application. Significant issues addressed by the CPRIT contract are listed in section 13 and section 14. All statutory provisions and relevant administrative rules can be found at www.cprit.texas.gov

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: Cancer Prevention and Research Institute of Texas

Sponsor Type: Corporate

Address: 1701 North Congress Avenue, Suite 6-127 Austin, TX 78701

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