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AACR Trailblazer Cancer Research Grants for Mid-Career Investigators

American Association for Cancer Research (AACR)

Grant Amount$1,000,000 USD

Grant Term3 Years

Start of Grant TermDecember 1, 2025

Letter of Intent DeadlineJune 12, 2025 1:00 PM (ET)

Letter of Intent Notification DateAugust 2025

Application DeadlineSeptember 25, 2025 1:00 PM (ET)

Decision DateNovember 2025

Additional InformationAdditional details regarding this grant can be found in the Program Guidelines and Letter of Intent Instructions. Final determinations of eligibility will not be completed until the AACR is in receipt of the submitted Letter of Intent.

Description

The AACR Trailblazer Cancer Research Grants for Mid-Career Investigators support cancer researchers at this critical juncture in their careers and enable them to make impactful advances against cancer. Projects may be exploratory, developmental, or proof of concept. By funding innovative and paradigm-shifting research, these grants aim to advance the understanding of cancer biology, drive groundbreaking translational discoveries, and/or improve patient outcomes.

The grants provide $1,000,000 over three years for expenses related to the research project, which may include salary and benefits of the grant recipient and collaborators (limited to 20% of the total budget), postdoctoral or clinical research fellows, graduate students (including tuition costs associated with graduate students’ education and training), or research assistants; research/laboratory supplies; equipment; publication charges for manuscripts that pertain directly to the funded project; and other research expenses. Indirect expenses are not allowed.

Specialties

Cancer

Eligibility Requirements

Applicants must hold a doctoral degree (PhD, MD, MD/PhD, or equivalent) and not currently be a candidate for a further doctoral degree.

At the start of the grant term on December 1, 2025, applicants must:

Hold a tenured appointment (or equivalent, if their institution does not follow a tenure system) at the rank of associate professor.
- If eligibility is based on a future position, the position must be confirmed at the time of letter of intent submission and CANNOT be contingent upon receiving this grant.
- If the future position is at a different institution than the applicant’s current institution, the applicant must contact the AACR’s Research and Grants Administration Department (the AACR’s RGA) at grants@aacr.org before submitting their letter of intent for information on additional verification materials/signatures that may be required.
Have received their first NIH R01 (or equivalent) award within the past 10 years from the grant start date. (i.e., grant cannot have been awarded before December 1, 2015).
Have independent laboratory space as confirmed by their institution.
Work at an academic, medical, or research institution anywhere in the world.

Sponsor Details

Sponsor Institute/Organizations: American Association for Cancer Research (AACR)

Sponsor Type: Corporate/Non-Profit

Address: 615 Chestnut St., 17th Floor Philadelphia, PA 19106-4404 USA Telephone: 215-440-9300 Email: aacr@aacr.org

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