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Genome Stability and Human Disease
(5/5) - 3 reviews
The University of Sheffield, The United Kingdom
Main Areas of Interest
Lecturing and Teaching:
This unit is designed for biomedical scientists and clinicians engaged in genetics. Biologists still think our genome is stable, yet the evidence shows that it suffers from breaking and sealing all the time. There are approximately 10,000 DNA breaks per cell per minutes. Breaking and sealing the DNA is a fine balance, which if lost leads to diseases such as neurological disorders and cancer. It is critical to be able to read and understand the composition of an entire genome as you would read a book from beginning to end. In this course, we will see how our genome is kept stable, techniques to read and understand its instability and the consequences they might have on human health.
Techniques You Will Learn
Learning Outcomes:
- Obtain fundamental information of endogenous and exogenous sources of DNA breaks
- Learn the various types of genomic instability and mechanisms of fixing DNA breaks
- Critically apply their understanding to different scenarios, including clinical case studies
- Critically understand the experimental approaches used to capture the evidence.
Learning and Teaching Resources:
The reading material can be found in this link:
https://www.dropbox.com/sh/1ruw5w61mpw5vu1/AABDPD_u5MspAnox4KLKnakBa?dl=0
Modules
Tasks and Timeline:
Module 1 (Week 1) Finding the Sources and Forms of DNA Breaks
This course begins with a series of classes illustrating the diverse nature of genomic breaks, the good, the bad and the ugly.
Module 2 (Week 2) Breaking and Sealing the Human Genome: A Question of balance – Clinical Case Study 1
In this course, we will see how the balance is tightly kept between breaking and sealing the human genome with real examples from the clinic. We will further learn how scientists collected the experimental evidence to reach to conclusions.
Module 3 (Week 3) Breaking and Sealing the Human Genome: A Question of balance – Clinical Case Study 2
Once we have learned how the imbalance could lead to disease, we will learn how scientists employed the same techniques to discover the cause of more human disorders resulting from defective DNA repair.
Module 4 (Week 4) The Beneficial Aspects of Inducing DNA Damage
In the previous course we learned how the imbalance between breaking and sealing our DNA causes disease. Here, we will learn why and how clinicians intentionally induce DNA damage to treat cancer. We will learn an important clinical concept called: Synthetic Lethality.
Module 5 (Week 5) Inflammation: The Silent Killer
Here, we will learn how DNA damage modulates the inflammatory response and mechanisms of tackling this connection to suppress inflammation.
Program Fee
| Total Number of Modules | 5 |
| Time duration of Each module | 45 minutes |
| Total Program Cost | $750 |
This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.
Who Can Apply
This unit is designed for biomedical scientists and clinicians engaged in genetics.
Host Details
Host Name: Professor Sherif El-Khamisy
Affiliation: The University of Sheffield
Address: The University of Sheffield, Western Bank ,Sheffield, S10 2TN, UK
Website URL: https://www.sheffield.ac.uk/mbb/staff/sherifelkhamisy
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
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Live Interactive One-On-One (Virtual)
Fellowship - Basic/Translational/Clinical Research Program
United Kingdom
Application Review Deadline:
Dec 1st, 2024
Featured Reviews
It was a wonderful experience and was very informative. Mentor explained very nicely and didn't know how quickly the sessions finished. My host was very supportive and taught me a lot. I feel blessed to get a wonderful mentor like him and I am highly grateful. I am very grateful to my host for the awesome traineeship and would be always thankful to him. I look at some of the ways these lessons have been structured, and I think to myself, I’m going to teach in a similar manner to what I saw. I always find it interesting, and it was also a good general brush-up. I personally request that if any opportunity there in US for such training please help me to get hands-on training. I felt that it would be much better if Molecular Techniques which we discussed explained in detail rather than brief discussion. Also missing hands on training. With out this learning molecular techniques is not fruitful. I felt that it would be much better if Molecular Techniques which we discussed explained in detail rather than brief discussion. Also missing hands on training. With out this learning molecular techniques is not fruitful.
I just wanted to start this email by saying a huge thank you for the Traineeship about Genome Instability and Human Disease. A quick summary of our activities include: Session 1 - Monday 25 May: 5:00 pm (UK time) - mainly discussion about physiological and pathological effects of DNA damage and Genome threats (endogenous and exogenous sources), key concepts such as R-loops, r-NTP, d-NTP, important events like spontaneous base loss and deamination during which mis-paring will lead to mutations. Session 2 - Tuesday 26 May: 12 noon (UK time) - Single-strand breaks (SSBs) and the repair mechanism involved, enzymes that participate, protein-protein interactions, and neurodegenerative diseases as consequences like AOA1. We even studied about abortive DNA events like ribose contamination. Session 3- Wednesday 27 May: 12 noon (UK time) - We focused on key enzymes like APTX and techniques to identify its activity. Also, we studied more neurodegenerative diseases as SCAN1 and proteins mainly affected as TDP1, how topoisomerases are directly connected to abortive events and SSBs, PARP, and XRCC1 involved in multiples diseases. Session 4- Thursday 28 May: 12 noon (UK time) - We focused more on how SSBs can impact the nervous system and especially the cerebellum repercussion, Functional Complementation, TDP2 activity, Comet Assay, HR/NHEJ mechanisms, PDBs. Session 5 - Friday 29 May: 12 noon (UK time) - DNA repair at the whole organism level and the repercussions and similarities noticeable when comparing results to mice experiments. Mitochondrial DNA, the repair pathways, and synthetic lethality (SSL), an amazingly complex subject but extremely important for cancer therapies and how its understanding can ultimately help the millions affected each year. Today, 29/05, Dr. Sherif, and I finished all of your 5 sessions schedules and finalized the program. The experience was of paramount importance for my Medical career to understand more about the key concepts of Genetics and the most important mechanisms related to DNA repair and how we can implicate its use in different outcomes like cancer, for example. I will definitely implement that knowledge during my career. I highly recommend the program and of course included the patience, thoughtfulness, and expertise of Dr. Sherif while being responsible for it. An applicant from Brazil
Program Logistics and Administrative Fees
This program has the following durations available:
| Duration | Fee |
|---|---|
| 2 weeks | $875.00 |
| 6 weeks | $1,500.00 |
| 12 weeks | $2,750.00 |
This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.
Who Can Apply
This unit is designed for biomedical scientists and clinicians engaged in genetics.
Host Details
Host Name: Professor Sherif El-Khamisy
Affiliation: The University of Sheffield
Address: The University of Sheffield, Western Bank ,Sheffield, S10 2TN, UK
Website URL: https://www.sheffield.ac.uk/mbb/staff/sherifelkhamisy
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
Questions and Answers
Commonly asked questions about this program from the host and other attendees.
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