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Nanopathology: The health impact of nanoparticles

Fondazione Nanodiagnostics

Dr. Antonietta Gatti is a physicist with a Ph.D. in Bioengineering from the University of Bologna. She currently serves as an Associate Professor at Italy's National Research Council, Institute of Science and Technology of Ceramic Materials. Additionally, she holds positions as a Professor at the University of Urbino and as a Visiting Professor at the Norwich University Applied Research Institutes (NUARI) in the United States.

Dr. Gatti is renowned for her discovery of "nanopathologies," which are diseases caused by exposure to engineered or incidental nanoparticles leading to nano-bio-interactions. Her interdisciplinary expertise spans physics, chemistry, biology, physiology, medicine, and pathology. Over her 30-year career, she has coordinated several European projects, including "Nanopathology," which developed new clinical diagnostic tools, and "DIPNA," focusing on nanotoxicology. She has also served as a consultant to the Italian Governmental Commission on Depleted Uranium and related diseases.

Main Areas of Interest

Areas of Interest

1. Fundamentals of Nanopathology

Introduction to nanoparticles and their biological effects
Mechanisms by which nanoparticles interact with human tissues and organs
The link between nanoparticles and diseases such as cancer, neurodegenerative disorders, and immune dysfunction

2. Health Impact of Nanoparticles

Role of nanoparticles in neonatal pathologies
Inhalation, ingestion, and dermal exposure pathways
Detection of nanoparticles in blood, biopsies, and surgical samples
Impact of nanoparticles from pollution, food, and medical devices

3. Advanced Microscopy and Analytical Techniques

Importance of high-resolution imaging in diagnosing nanoparticle-induced diseases
Understanding tissue response to nanoparticles using Scanning Electron Microscopy (SEM)
Energy Dispersive Spectroscopy (EDS) for identifying the chemical composition of foreign bodies in human tissues

4. Environmental and Food Safety

Nanoparticles in processed foods, air pollution, and water sources
Conducting food sample analyses for nano-contaminants
Public health implications of exposure to engineered nanoparticles

5. Biomedical Research & Clinical Applications

Case studies of nanoparticles found in cancerous tissues
The role of nanoparticles in immune disorders and chronic diseases
Translating nanopathology research into clinical diagnostics and treatment approaches

Specialties

Drug Delivery

Pathology

Drug Development

Pharmaceuticals

Techniques You Will Learn

1. Scanning Electron Microscopy (SEM) for Nanoparticle Analysis

Preparation of biological samples for electron microscopy
Image acquisition and interpretation of ultramicrostructural features
Identification of nanoparticles within human tissues

2. Energy Dispersive Spectroscopy (EDS) for Elemental Analysis

Detection and characterization of the chemical composition of foreign particles
Differentiation between biological and non-biological nanostructures
Correlation of nanoparticle exposure with disease pathology

3. Sample Preparation for Pathological Investigation

Tissue sectioning techniques for microscopic evaluation
Staining methods to enhance nanoparticle visibility
Preservation and mounting of biopsy and surgical samples

4. Ultramicrostructural Analysis of Pathological Tissues

Identification of nanoparticles in tumors, lung, liver, and kidney samples
Understanding tissue changes caused by nanoparticle accumulation
High-resolution imaging for clinical diagnostics and biomedical research

5. Nanoparticle Screening in Food and Environmental Samples

Analysis of processed foods for the presence of nanoparticles
Investigation of nanoparticle contamination in drinking water and air samples
Assessment of health risks associated with chronic nanoparticle exposure

Curriculum

6-Week General Curriculum

can be customised

Accommodation

Try airbnb.com

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.

Who Can Apply

Target Audience: PhD students, postdocs, medical professionals, regulatory specialists, and industry scientists.

Host Details

Host Name: Dr. Antonietta Gatt

Affiliation: Fondazione Nanodiagnostics

Address: Via Enrico Fermi, 1L, 41057 Spilamberto MO, Italy

Website URL: https://www.nanodiagnostics.it/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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