Trialect

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Cancer Biology and Combinatorial Antitumor Therapies

University of Rome
(5/5) - 1 reviews

The University of Rome, Rome, Italy

Main Areas of Interest

The main research areas of our group are:

Molecular basis of de-regulated metabolism of cancer cells;
Molecular basis of onset and reversion of chemoresistance in human tumors;
Validation of new combinatorial antitumor therapies (e.g. dietary regimen; nutraceuticals -based chemotherapy; lipid metabolism modulatory drugs).

Techniques You Will Learn

Experimental techniques you will learn during your program here:

Cell culture using: human and murine chemo-sensitive and chemo-resistant tumor cells; primary tumor samples (hepatocarcinoma)
cell culture and transformation (gene silencing, gene: overexpression)
cell co-culture models: peripheral blood mononuclear cells/tumor cells
cell viability/toxicity assays (necrosis, apoptosis, cell cycle analysis, DNA genotoxicity, autophagy, senescence)
cell metabolism assays (enzymatic activity by spectrofluorometric and chemiluminescencse-based assays; metabolic radiolabeling)
chromatography (thin layer chromatography, ion exchange chromatography, affinity chromatography)
immunoblotting, co-immunoprecipitation
cell subfractioning
qualitative and quantitative PCR; PCR-arrays
chromatin immunoprecipitation (ChIP)
ELISA
flow cytometry
fluorescence and confocal microscope
immunohistochemistry
oncological mouse models: mice handling, tumor monitoring, drug administration, ex vivo immune system activity of murine models.

Curriculum

6-12 weeks curriculum

Fellows will be supported to settle down into their new environment (find appropriate accommodation, locate amenities, etc.) and register at the University, during which an ID card will be issued. A desk space will be allocated. Full induction (safety, laboratory practices, personal welfare, etc.) will be provided by the University’s designated staff and by myself. I will arrange an initial meeting with the fellow to discuss the objectives of the training and the expected mechanisms of their fulfillment. Experimental plans with realistic timelines will then be decided.

The fellow will be fully trained to run each experiment. They will then be allowed to attempt the experiment themselves, with the trainer present during their first run. They will be able to engage with me (supervisor) and other members of the laboratory to discuss any aspects of the general running of the laboratory or specific protocols that they require clarifications on. They will also be trained in how to analyze and interpret their data. I will arrange a weekly or bi-weekly meeting with the fellow to discuss and reflect on their progress and decide the next set of experiments based on data generated. A fellow must keep adequate and accurate records of their work using the laboratory book provided.

The fellow will be given the opportunity to partake in research group meetings and other academic activities within the School and the University, including attending relevant bespoke workshops on research career development (e.g., on manuscript writing, grant writing, networking, etc.). They will also be encouraged to present their work orally at a research group meeting at least once before they complete their visit.

Towards the end of the training, I will have a meeting with the fellow to discuss plans to publish their work (if enough data collected) or disseminate their findings in a future conference. They will also be assisted to identify existing or future opportunities, globally or within their original work environment, that the training has empowered them to be eligible and competitive for and how they can be assisted to access them and also integrate the knowledge and skills gained into their further research or professional practice roles.

All throughout the training any particular challenges or specific requests of a fellow will be fully considered to ensure a responsive, relevant and adequate training plan is developed for them.

Accommodation

Try Airbnb

Guest house/accommodation near the lab (20 minutes walking; bus transfer)

website (Italian; possible online reservation): https://campusx.it/

website (English; possible online reservation): https://campusx.it/

The network of University: http://www.scienze.uniroma2.it/

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

This program allows Merit Applications. If you successfully are awarded a merit application - Trialect will take care of all bench and service fees, but you will have to take care of travel and accommodation. All applications will be scrutinized under the merit category. Considering 50 million health professionals around the world, the chances of getting selected under the merit category would be very low.

Who Can Apply

physicians and scientists from around the world can apply

Host Details

Host Name: Prof. Maria Rosa Ciriolo

Affiliation: University of Rome

Address: Via della Ricerca Scientifica, Rome, Italy

Website URL: http://bio.uniroma2.it/ciriolo-english/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

Onsite/On-Campus Program

Fellowship - Basic/Translational/Clinical Research Program

Italy

Application Review Deadline:

Oct 1st, 2024

Apply Now

Featured Reviews

Nathaly Mendoza 10 months ago

(5/5)

I had a wonderful experience at the lab of Prof. Ciriolo. It was really enriching, I gained experience and knowledge in cancer research, the team was receptive, friendly and helpful, they teach you with great dedication and patience. Prof. Ciriolo personally took part to make sure I gained the experience I needed at her lab, she was easily accessible throughout the training period to solve any doubt or problem. I will like to thanks Prof. Ciriolo, Dr. Fabio, Dr. Serena and all my colleagues for this excellent experience. I highly recommend this program.