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Sustained collaboration of national and regional cancer funders to support the Cancer Mission through translational research

European Commission

Expected Outcome:

The successful proposal should aim to deliver results that are directed and tailored towards and contribute to all the following expected outcomes:

National and regional cancer funders across Europe (i.e. representing Northern, Southern, Central, Eastern and Western Europe), based on a common strategic research and innovation agenda, deliver:

1. At least four transnational calls for proposals addressing translational cancer research, resulting in collaborative grants to academic investigator-led third parties;

2. Streamlined national, regional and foundation-based or charity-based practices in organising peer-reviewed translational cancer research and innovation funding between the partners, with attention to exploring novel funding schemes and initiatives as well as sustainability of a network of funders where appropriate;

Scope:

Common challenges in translational cancer research require effective transnational cooperation on prioritised efforts, leveraging national, regional and charity-based resources and appropriate funding schemes. Important achievements of translational cancer research funding by long-term collaboration of national and philanthropy funding organisations have been obtained by the TRANSCAN network under the Seventh Framework Programme for Research and Innovation (2007-2013) and Horizon 2020 (2014-2020)[1].

More efforts are warranted to address the potential for sustainable coordination, the access to and sharing of research data to enhance the understanding of cancer as well as to further the alignment of national, regional and foundation or charity-based cancer research and innovation programmes and activities in Member States and Associated Countries. The EU contribution will not be used to co-fund the grants to third parties described hereunder.

The proposal should address all the following:

Align, coordinate and support efforts from and between national and regional public and private research funding programmes on translational cancer research to issue at least four joint transnational calls which are integrated with the Cancer Mission and the Europe’s Beating Cancer Plan;
Pool the necessary financial resources from the participating national and regional research programmes as well as, where appropriate, leverage resources from pertinent foundations, charities and transnational initiatives, to support at least four joint transnational calls for proposals which are integrated with the Cancer Mission and the Europe’s Beating Cancer Plan, while avoiding overlaps with EU-funded research under Horizon Europe;
Demonstrate the potential impact of collaboration between national and regional transnational research and innovation programmes, as well as demonstrate a leverage effect on European and national research and competitiveness using key indicators;
Consider novel funding schemes and joint activities such as analyses of research and innovation funding programmes, impact, dissemination, citizen (including cancer patients), engagement, and training;
Datasets produced by collaborative grants to academic investigator-led third parties should be made FAIR whenever possible, while tools and models should follow the principles of open science, taking advantage of current European research infrastructures and supporting the future UNCAN.eu research data platform.

AI Based Application Success Predictor

🧪 1. Scientific Excellence Is Paramount

For ERC grants, excellence is the sole selection criterion—evaluations focus exclusively on the quality of the research and track record .

Peer-reviewers adhere strictly to predefined criteria (e.g., Horizon ITN evaluations), and weaknesses—rather than strengths—often decide the outcome .

🌍 2. Strategic Alignment with EU Priorities

Horizon Europe emphasizes Green & Digital Transitions and resilience, with specific budget steering across biodiversity, climate, digital, and societal missions .

Proposals that clearly align with these strategic orientations and EU missions are significantly more competitive.

🤝 3. Strong, Diverse European Consortia

Horizon projects demand well-balanced consortia across Europe—geographically and disciplinarily diverse, including academia, industry, SMEs, NGOs .

Effective leadership, communication, trust, and active collaboration are key success factors.

🧴 4. Proven Research Infrastructure & Track Record

A strong publication record—especially in high-impact venues—and prior grant awards bolster chances .

ERC starting, consolidator, or advanced grants require exceptional citation records, strong proposals, and investigator track records .

📈 5. Robust Project Management

For large collaborative grants, project coordination, administration, and communication are just as crucial as scientific content .

Demonstrating realistic budget planning (100% direct costs + 25% indirect costs), administrative frameworks, and governance structures strengthens proposals .

💼 6. Fostering Mobility & Career Growth

Marie Skłodowska-Curie fellowships emphasize researcher mobility, interdisciplinary training, and developing future talent .

🧷 7. Geographical & Gender Equity

Northern and certain Eastern European institutions currently have higher success rates (≈22% vs below 18% in Southern Europe) .

ERC gender data: male and female applicants have similar success rates, though male applicants apply more frequently .

📌 Key Takeaways

Factor	Why It Matters
Excellence-first	Superior science and investigator record are non-negotiable.
Strategic fit	Alignment with EU green, digital, and mission goals is essential.
Consortium quality	Geographic, sectoral, and expertise balance enhances impact.
Management capacity	Good PM builds confidence in successful delivery.
Experience track record	Publications, previous funding, and citations build credibility.
Mobility & careers	MSCA focuses on researcher development and interdisciplinary collaboration.

🧭 Applicant Tips

Master criteria & avoid weaknesses: Make sure your proposal addresses common reviewer pitfalls—methodology, innovation, budget clarity.

Map to EU priorities: Explicitly connect your objectives to Horizon Europe’s strategic plan (2025–2027).

Build strong consortia early: Prioritize complementary expertise, geography, gender balance, and partner roles.

Show robust project management: Include a Work Package structure, governance plans, and clear communication strategies.

Leverage your track record: Highlight high-impact papers, leadership in projects, and previous awards.

Consider MSCA opportunities: Use them for mobility grants or integrating training into your project.

✅ In Summary

To maximize success with European Commission grants—especially ERC or Horizon Europe—focus relentlessly on scientific excellence, strategic EU alignment, consortium strength, and solid project planning. Combine these with a strong publication record and researcher development elements, and aim to close off any potential reviewer concerns.

Specialties

Cancer

Eligibility Requirements

General conditions

1. Admissibility Conditions: Proposal page limit and layout

described in Annex A and Annex E of the Horizon Europe Work Programme General Annexes.

Proposal page limits and layout: described in Part B of the Application Form available in the Submission System.

2. Eligible Countries

described in Annex B of the Work Programme General Annexes.

A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.

3. Other Eligible Conditions

described in Annex B of the Work Programme General Annexes.

4. Financial and operational capacity and exclusion

described in Annex C of the Work Programme General Annexes.

5a. Evaluation and award: Award criteria, scoring and thresholds

are described in Annex D of the Work Programme General Annexes.

5b. Evaluation and award: Submission and evaluation processes

The thresholds for each criterion will be 4 (Excellence), 4 (Impact) and 4 (Implementation). The cumulative threshold is 12.

are described in Annex F of the Work Programme General Annexes and the Online Manual.

5c. Evaluation and award: Indicative timeline for evaluation and grant agreement

described in Annex F of the Work Programme General Annexes.

6. Legal and financial set-up of the grants

Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021 authorising the use of lump sum contributions under the Horizon Europe Programme – the Framework Programme for Research and Innovation (2021-2027) – and in actions under the Research and Training Programme of the European Atomic Energy Community (2021-2025) [[This decision is available on the Funding and Tenders Portal, in the reference documents section for Horizon Europe, under ‘Simplified costs decisions’ or through this link: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/guidance/ls-decision_he_en.pdf]].

described in Annex G of the Work Programme General Annexes.

Specific conditions

described in the [specific topic of the Work Programme]

Sponsor Details

Sponsor Institute/Organizations: European Commission

Sponsor Type: Corporate/Non-Profit

Address: Rue de la Loi 200, 1049 Brussels, Belgium

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