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Research grants
- Research grant proposals should address one of the following four high-priority areas:
- Understanding phenotypic heterogeneity in TSC, i.e., research on genetic, biologic, or environmental factors that might explain why TSC is so different from person to person
- Gaining a deeper knowledge of TSC signaling pathways and the cellular consequences of TSC deficiency
- Improving TSC disease models, whether cell-based, tissue-based, or animal models
- Developing clinical biomarkers or patient-reported outcome measures for TSC, particularly those that assess disease burden or stratify an individual’s risk of progression or developing specific manifestations of TSC
- Research grant awards are intended to provide funding for an independent researcher, whether tenure-track faculty, non-tenure-track faculty or staff, or an equivalent level at a research institution or company. The award may support laboratory supplies, personnel costs, services, or equipment necessary to conduct the proposed research.
- The TSC Alliance fully supports collaborative projects between co-investigators, but only one investigator may be considered the “Principal Investigator” for the purpose of applying through the online system.
Duration and Budget
- Typical duration is two years. Can be shorter if appropriate for the project.
- Maximum total costs of $75,000 per year ($150,000 total).
- Postdoctoral Fellowship proposals must include up to $1,500 for travel expenses to attend a relevant scientific meeting. This is optional but strongly encouraged for Research Grant proposals.
Indirect Costs
For research grants, including postdoctoral fellowships, the TSC Alliance allows no more than 10 percent of the total costs to be applied to indirect costs. As an example, a maximum of $15,000 indirect costs may be included within an award totaling $150,000.
The TSC Alliance does not pay indirect costs on contracts based on delivering a tangible or measurable work product. Examples of such contracts are those to enter data into the TSC Natural History Database or collection of blood or remnant surgical tissue for the TSC Biosample Repository.
AI Based Application Success Predictor
1. 🧠 Clear Focus on Tuberous Sclerosis Complex (TSC)
The core predictor of success is a research proposal directly relevant to:
Mechanisms of disease (TSC1/TSC2, mTOR pathway)
Preclinical or translational research
Biomarkers and diagnostics
TSC-related epilepsy, autism, or tumors (e.g., SEGAs, angiomyolipomas)
Therapeutic targets and clinical trials
✅ Success Predictor: You propose a study clearly focused on understanding or treating TSC-specific pathophysiology or symptoms.
2. 🧪 Strong Preliminary Data
Competitive applicants often provide:
Pilot data showing feasibility and rationale
Prior studies linking their lab to mTOR/TSC signaling
Publications in neuroscience, genetics, or rare disease journals
✅ Success Predictor: You’ve already engaged in TSC-relevant research, even at a small scale.
3. 👩🔬 Investigator Experience & Institutional Support
TSC Alliance supports:
Established researchers with a strong track record in neurogenetics or rare disease biology
New investigators partnering with experienced mentors
Institutions with neurodevelopmental labs, imaging cores, or access to TSC animal models or patient registries
✅ Success Predictor: You have either a reputation in related fields or a strong mentorship/partnership network.
4. 🔁 Alignment with Ongoing TSC Alliance Initiatives
Your proposal aligns with ongoing TSC Alliance efforts like:
Preclinical Consortium
Clinical Research Consortium
Biosample Repository
Natural History Database
Clinical trials readiness tools
✅ Success Predictor: You integrate with or leverage existing TSC Alliance resources or networks.
5. 🔬 Translational Potential
High-priority projects are those that:
Advance therapeutic development
Provide biomarkers for clinical trials
Bridge basic and clinical science (e.g., from model to patient)
✅ Success Predictor: Your work can translate to real-world TSC treatment or care improvements.
🧾 Types of TSC Alliance Funding
| Program | Description | Amount |
|---|---|---|
| Postdoctoral Fellowships | Support early-career researchers | $75,000–$100,000/year |
| Targeted Research Grants | Fund hypothesis-driven studies | ~$75,000–$150,000 |
| Preclinical Consortium Projects | For therapeutic screening | Varies (co-funded) |
| Biosample/Data Access Grants | Use of TSC databases or biobank | Often included in other grants |
Co-funding opportunities may be available with DoD CDMRP (TSCRP), NIH, or private industry partners.
🧬 Recent Funded Topics (Examples)
Immune dysregulation and inflammation in TSC
Brain connectome abnormalities and seizure focus
Gene therapy vectors targeting TSC1/TSC2 mutations
Drug repurposing for neuropsychiatric symptoms (e.g., everolimus alternatives)
Deep phenotyping in early-onset TSC
✍️ Tips for Strong Proposals
Show clear relevance to TSC-specific mechanisms or treatment gaps
Reference TSC Alliance priorities or tools (biobank, database, Natural History Study)
Include patient-centered aims or outcome measures
Highlight collaboration with TSC experts or institutions
For early-career applicants, show solid mentorship plan
Specialties
Eligibility Requirements
This opportunity is open to all investigators at established academic or research institutions or at pharmaceutical or biotech companies worldwide. Researchers residing in the United States do not need to be U.S. citizens to apply for funding.
Sponsor Details
Sponsor Institute/Organizations: TSC Alliance
Sponsor Type: Corporate/Non-Profit
Address: 8737 Colesville Road, Suite 400 Silver Spring, Maryland 20910-3921 USA 800.225.6872 (Toll-Free) 301.562.9890 info@tscalliance.org EIN: 95-3018799
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Grant
Final Deadline:
Aug 25, 2025
Funding Amount:
$75,000
Host Details
Affiliation: TSC Alliance
Address: 8737 Colesville Road, Suite 400 Silver Spring, Maryland 20910-3921 USA 800.225.6872 (Toll-Free) 301.562.9890 info@tscalliance.org EIN: 95-3018799
Website URL: https://www.tscalliance.org/researchers/grants-funding/
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
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