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Lupus Innovation Award

Lupus Research Alliance

The Lupus Innovation Award ($300,000 over 2 years) provides support for pioneering, high-risk, high-reward approaches to major challenges in lupus research. Special emphasis is placed on lupus studies exploring fundamental mechanisms, novel targets and pathways, novel technologies, and interdisciplinary approaches. Both early career and established investigators new to lupus with highly innovative ideas are encouraged to apply.

AI Based Application Success Predictor

🧬 1. Strong Focus on Lupus and Autoimmune Mechanisms

Projects must be directly relevant to lupus — including:

SLE pathogenesis

Lupus nephritis, cutaneous lupus, or neuropsychiatric lupus

Innate and adaptive immune dysregulation (e.g., T cells, B cells, interferons)

Biomarkers, therapeutic targets, or immune profiling

Proposals that address clinical heterogeneity or flare prediction are prioritized.

🧪 2. Innovative, High-Risk/High-Reward Research

Especially for the Distinguished Innovator Award, LRA seeks:

Bold, novel ideas unlikely to be funded by NIH or other traditional sources.

Early-stage or disruptive science with potential for breakthroughs in treatment or understanding of lupus.

Creativity, originality, and transformative impact are strong success predictors.

📊 3. Preliminary Data and Research Rigor

Even high-risk ideas require some preliminary data or prior relevant publications.

LRA places high value on methodological rigor, clear hypotheses, and feasibility of completing aims.

Use of modern technologies (e.g., single-cell omics, machine learning, human immune profiling) is common in funded projects.

🧑‍🔬 4. Track Record of the Principal Investigator

Strong history of research in immunology, autoimmunity, or lupus specifically.

Publications in top-tier journals (Nature Immunology, JCI, Lupus Science & Medicine, etc.).

For early-career grants: evidence of productivity, strong mentorship, and long-term interest in lupus research.

🏛 5. Institutional and Collaborative Strength

Affiliation with research institutions or academic centers with a focus on rheumatology, immunology, or lupus clinics.

Proposals with access to well-characterized patient cohorts or biorepositories are often stronger.

Multidisciplinary collaboration (e.g., immunology + bioinformatics + clinical trial design) is a plus.

🎯 6. Alignment with LRA’s Mission

Clear potential for:

Translational impact

Improved diagnostics, treatment, or outcomes

Path to therapeutic development

Patient-centered research and real-world applicability are valued.

📋 LRA Funding Programs Include:

Distinguished Innovator Award
– Up to $1 million over 4 years
– For senior investigators with transformative ideas

Target Identification in Lupus Grant
– ~$300,000 over 2 years
– For identifying and validating new therapeutic targets

Global Team Science Award
– For international collaborative teams with synergistic lupus expertise

LRA–Columbia–Weill Precision Medicine Grant
– Focused on genomics, biomarkers, and stratified medicine in lupus

Young Investigator Awards (less frequent but occasionally available)

Specialties

Technology Development

Eligibility Requirements

The LIA supports pioneering, high-risk, high-reward approaches to major challenges in lupus research. The overarching goals of the LIA are to: (1) promote investigation of underexplored pathways and fundamental mechanisms of lupus and its complications and (2) initiate transformative discoveries in lupus that can drive the development of safer and more effective treatments or novel biomarkers. All studies should have a clear and direct relevance to people with lupus and should offer the potential to improve the standard of care for the disease or usher in a cure.

Sponsor Details

Sponsor Institute/Organizations: Lupus Research Alliance

Sponsor Type: Corporate/Non-Profit

Address: 270 Madison Avenue, Suite 300, New York, NY 10016 | 646-884-6000

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