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Individual Investigator Research Awards for Early-Onset Cancers

Cancer Prevention and Research Institute of Texas

This targeted Individual Investigator Research Award for Early-Onset Cancer invites innovative research projects that will advance our understanding of the etiology, risk factors, molecular pathobiology, and potential treatments for early-onset cancers. The goal of this RFA is to fund exceptionally innovative research projects with great potential impact that are directed by a single investigator or multiple investigators. Examples of projects responsive to this RFA include, but are not limited to, scientific proposals addressing the following:

• Identification of risk factors for early-onset cancers affecting Texans, including social, environmental, behavioral, and biological factors

• Identification of hereditary cancer syndromes by genetic testing and defining the associated cancer risk

• Research on disparities in clinical, molecular, and biological features of early-onset cancers between genders and/or between ethnic, demographic, and socioeconomic groups

• Etiology of early-onset cancers, including genetic factors or exposure to environmental agents

• Clinical, morphological, molecular, “omics,” and/or immunological characterization of early-onset cancers

• Preclinical studies of models for early-onset cancers, including development and characterization of animal models, patient-derived xenografts and other models using tumor tissues, and screening for new therapies or evaluation of targeted therapies, immunotherapies, and new drugs

• Development of new methods for diagnosing or identifying prognostic features of earlyonset cancers, eg, the application of artificial intelligence to analyze images or large data sets to provide new biological and clinical information.

FUNDING INFORMATION Applicants may request a maximum of $300,000 in total costs per year for up to 3 years for research. Funds may be used for salary and fringe benefits, research supplies, equipment, subject participation costs, and travel to scientific/technical meetings or collaborating institutions. Requests for funds to support construction and/or renovation will not be approved under this funding mechanism. State law limits the amount of indirect costs to no more than 5% of the total award amount.

Specialties

Cancer

Oncology

Eligibility Requirements

The applicant must be a Texas-based entity. Any not-for-profit institution or organization that conducts research is eligible to apply for funding under this award mechanism. A public or private company is not eligible for funding under this award mechanism; these entities must use the appropriate award mechanism(s) under CPRIT’s Product Development Research Program.

• The PI must have a doctoral degree, including MD, PhD, DDS, DMD, DrPH, DO, DVM, or equivalent, and must be a full-time resident of Texas during the time the research that is the subject of the grant is conducted.

• The PI must hold an appointment at the rank of assistant, associate or professor tenure track or tenured (or equivalent) at an accredited academic institution, research institution, industry, government agency, or private foundation. The PI must also have appropriate designated laboratory or clinical space, or other facilities in which to conduct the proposed studies.

• This award mechanism allows MIs for projects that require a team science approach (see the IFA for guidelines on CPRIT rules for MI awards).

• For applications that include 1 PI, the PI is required to maintain a minimum of 15% level of effort through the duration of the entire award period. For applications that include MIs, each PI is required to maintain a minimum of 10% effort through the entire duration of the award period.

A PI may not submit applications to this RFA and to RFA R-26.1-IIRA, RFA R-26.1- IIRACSBC, RFA R-26.1-IIRACCA, RFA R-26.1-IIRACT, or RFA R-26.1-IIRAP.

• A PI may submit only 1 application, either a new, resubmission, or renewal application under this RFA during this funding cycle.

• A PI may not be a part of more than 1 application, whether as a single applicant or as an MI on an application, under this RFA and RFA R-26.1 IIRA, RFA R-26.1-IIRACSBC, RFA R-26.1-IIRACCA, RFA R-26.1-IIRACT, or RFA R-26.1-IIRAP.

• An individual may serve as a PI on no more than 3 active CPRIT Academic Research grants. Recruitment grants and Research Training Awards do not count toward the 3-grant maximum; however, CPRIT considers MIRA Project MIs equivalent to a PI. For the purpose of calculating the number of active grants, CPRIT will consider the number of active grants at the time of the award contract effective date (for this cycle expected to be December 1, 2025).

• Applications that address prevention and early detection population-based studies, cancers in children and adolescents, computational systems biology of cancer, or innovative clinical trials should be submitted under the appropriate targeted RFA.

• Collaborating organizations may include public, not-for-profit, and for-profit entities. Such entities may be located outside of the State of Texas, but non-Texas-based organizations are not eligible to receive CPRIT funds.

• An applicant is eligible to receive a grant award only if the applicant certifies that the applicant institution or organization, including the PI, any senior member or key personnel listed on the grant application, or any officer or director of the grant applicant’s institution or organization (or any person related to 1 or more of these individuals within the second degree of consanguinity or affinity) has not made and will not make a contribution to CPRIT or to any foundation specifically created to benefit CPRIT.

• An applicant is not eligible to receive a CPRIT grant award if the applicant PI, any senior member or key personnel listed on the grant application, or any officer or director of the grant applicant’s organization or institution is related to a CPRIT Oversight Committee member.

• The applicant must report whether the applicant institution or organization, the PI, or other individuals who contribute to the execution of the proposed project in a substantive, measurable way, regardless of whether these individuals are slated to receive salary or compensation under the grant award, are currently ineligible to receive federal grant funds or have had a grant terminated for cause within 5 years prior to the submission date of the grant application.

• CPRIT grants will be awarded by contract to successful applicants. Certain contractual requirements are mandated by Texas law or by administrative rules. Although applicants need not demonstrate the ability to comply with these contractual requirements at the time the application is submitted, applicants should make themselves aware of these standards before submitting a grant application. Significant issues addressed by the CPRIT contract All statutory provisions and relevant administrative rules can be found at www.cprit.texas.gov.

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: Cancer Prevention and Research Institute of Texas

Sponsor Type: Corporate

Address: 1701 North Congress Avenue, Suite 6-127 Austin, TX 78701 United States

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