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Notice of Special Interest (NOSI): Role of social function on SUD treatment and outcomes

National Institutes of Health

This notice of special interest (NOSI) invites both preclinical and clinical applications to evaluate the role of social functioning in the treatment of substance use disorders (SUDs) and as potential endpoints for therapeutics development.

SUDs often correspond with social dysfunction. Namely, DSM V diagnostic criteria for SUD include 1) reduced involvement in social activities because of substance use, 2) failure to meet occupational and societal obligations due to substance use, and 3) continued substance use in the face of recurrent interpersonal problems. These diagnostic criteria illustrate that social dysfunction is not only a common consequence of SUD, but also a clinically recognized feature of its pathology. Therefore, interventions that improve social function would be expected to reduce SUD diagnostic scores related to social dysfunction and could also promote a decrease in drug use. However, the relationships between social function, SUD severity, and drug use have not been explicitly determined. This Notice of Special Interest invites both preclinical and clinical applications to evaluate the role of social functioning in the treatment of SUDs as well as the development of social function endpoints for therapeutics development.

This notice applies to due dates on or after October 5, 2023 and subsequent receipt dates through September 8, 2026.

NOT-DA-25-026

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Medical

Medical - Translational

Medical - Clinical Science

Social Sciences

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Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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