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Funding Opportunity




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Accelerating Impact for Hard-to-Treat Cancers Award

Children's Cancer Research Fund

This award supports basic, clinical, and population studies focused on hard-to-treat cancers where treatment success has remained out of reach. Projects may include pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects, development of new methodology, and development of new research technology. A Hard-to-Treat Award is $250,000 for a two-year period. Children’s Cancer Research Fund defines hard-to-treat cancer as 5-year survival of less than 70% in an individual cancer (e.g. osteosarcoma, AML, DIPG), in a cancer with unfavorable behavior (e.g. relapse or metastasis), or in a molecular defined subtype (e.g. MLL rearranged leukemia, PAX3-FOXO1 rearranged RMS). Cancer with survival <70% in demographic groups defined by age, sex, or race/ethnicity may also qualify if a biological hypothesis is being pursued.

AI Based Application Success Predictor

1. Alignment with CCRF’s Focus Areas

CCRF targets research in hard‑to‑treat pediatric cancers, survivorship, and health disparities—especially projects addressing cancers with <70% survival or inequities in care .
Best predictor: proposal directly matches one of these themes.

🧪 2. Innovation & Seeding Impactful Research

CCRF prioritizes pilot/feasibility studies that serve as springboards for larger federal or foundation funding .
Recommendation: Focus on bold, proof‑of‑concept studies with translational value.

📊 3. Strong Study Design & Feasibility

As peer-reviewed by their Research Advisory Committee, successful proposals demonstrate:

Clear hypotheses and methods

Appropriate sample sizes and feasibility

Preplanned evaluation metrics and milestones

Value for money and justified budgets 

🤝 4. Institutional and Collaborative Support

Letters from mentor(s) or institutional leaders indicate readiness to execute the work. Multicenter or interdisciplinary partnerships—especially for hard-to-treat categories—add credibility .

👩‍👧‍👦 5. Patient-Centered & Equity Focus

For survivorship and disparities awards, applications that include patient perspectives—especially from underserved communities—stand out .

📈 6. Proof of Track Record & Growth

Even though CCRF supports emerging investigators, having preliminary data, relevant experience, or a track record of publication boosts competitiveness .

📝 7. Peer-Review Process

Applications undergo peer review by multiple experts, including Pediatric Oncology researchers, with feedback provided—indicating the importance of strong science and expert endorsement .

🧩 Summary Table

PredictorWhat It Means
Theme alignmentMatches CCRF’s 3 focus areas
Pilot translational designFeasible, innovative seed studies
Solid methodologyClear aims, methods, metrics
Institutional supportLetters, partnerships, resources
Patient centricity & EDIEmbedded in project design
Demonstrated capacityPilot data and investigator experience
Peer review fitStrong scientific endorsement

 

💡 Tips to Strengthen Your Application

Select the relevant award—whether hard-to-treat, survivorship, or disparities.

Frame as a pilot that scales—outline how it will lead to bigger grants.

Validate methods—include power calculations, endpoints, and contingency plans.

Secure strong endorsement—get institutional letters and confirm IRB/logistics alignment.

Include patient voices—public/patient engagement and underserved focus matters.

Leverage preliminary data—even small datasets or pilot observations help reassure reviewers.

Highlight next steps—show how funding will catalyze continued progress.

• Applicants must be PI-eligible at their sponsoring institution

 • Awardees are required to commit at least 10 percent of their research effort each year to activities supported by this award 

• Applicant U.S. citizenship is not a requirement

• Applications will be accepted only from U.S. based institutions

Sponsor Institute/Organizations: Children's Cancer Research Fund

Sponsor Type: Corporate/Non-Profit

Address: 1650 W 82nd St., Suite 400 Minneapolis, MN 55431

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Grant, Award

Letter Of Intent Deadline:

Jul 09, 2025

Final Deadline:

Jul 09, 2025

Funding Amount:

$125,000

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