This award supports basic, clinical, and population studies focused on hard-to-treat cancers where treatment success has remained out of reach. Projects may include pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects, development of new methodology, and development of new research technology. A Hard-to-Treat Award is $250,000 for a two-year period. Children’s Cancer Research Fund defines hard-to-treat cancer as 5-year survival of less than 70% in an individual cancer (e.g. osteosarcoma, AML, DIPG), in a cancer with unfavorable behavior (e.g. relapse or metastasis), or in a molecular defined subtype (e.g. MLL rearranged leukemia, PAX3-FOXO1 rearranged RMS). Cancer with survival <70% in demographic groups defined by age, sex, or race/ethnicity may also qualify if a biological hypothesis is being pursued.
CCRF targets research in hard‑to‑treat pediatric cancers, survivorship, and health disparities—especially projects addressing cancers with <70% survival or inequities in care .
Best predictor: proposal directly matches one of these themes.
CCRF prioritizes pilot/feasibility studies that serve as springboards for larger federal or foundation funding .
Recommendation: Focus on bold, proof‑of‑concept studies with translational value.
As peer-reviewed by their Research Advisory Committee, successful proposals demonstrate:
Clear hypotheses and methods
Appropriate sample sizes and feasibility
Preplanned evaluation metrics and milestones
Value for money and justified budgets
Letters from mentor(s) or institutional leaders indicate readiness to execute the work. Multicenter or interdisciplinary partnerships—especially for hard-to-treat categories—add credibility .
For survivorship and disparities awards, applications that include patient perspectives—especially from underserved communities—stand out .
Even though CCRF supports emerging investigators, having preliminary data, relevant experience, or a track record of publication boosts competitiveness .
Applications undergo peer review by multiple experts, including Pediatric Oncology researchers, with feedback provided—indicating the importance of strong science and expert endorsement .
🧩 Summary Table
Predictor | What It Means |
---|---|
Theme alignment | Matches CCRF’s 3 focus areas |
Pilot translational design | Feasible, innovative seed studies |
Solid methodology | Clear aims, methods, metrics |
Institutional support | Letters, partnerships, resources |
Patient centricity & EDI | Embedded in project design |
Demonstrated capacity | Pilot data and investigator experience |
Peer review fit | Strong scientific endorsement |
Select the relevant award—whether hard-to-treat, survivorship, or disparities.
Frame as a pilot that scales—outline how it will lead to bigger grants.
Validate methods—include power calculations, endpoints, and contingency plans.
Secure strong endorsement—get institutional letters and confirm IRB/logistics alignment.
Include patient voices—public/patient engagement and underserved focus matters.
Leverage preliminary data—even small datasets or pilot observations help reassure reviewers.
Highlight next steps—show how funding will catalyze continued progress.
• Applicants must be PI-eligible at their sponsoring institution
• Awardees are required to commit at least 10 percent of their research effort each year to activities supported by this award
• Applicant U.S. citizenship is not a requirement
• Applications will be accepted only from U.S. based institutions
Sponsor Institute/Organizations: Children's Cancer Research Fund
Sponsor Type: Corporate/Non-Profit
Address: 1650 W 82nd St., Suite 400 Minneapolis, MN 55431
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Jul 09, 2025
Jul 09, 2025
$125,000
Affiliation: Children's Cancer Research Fund
Address: 1650 W 82nd St., Suite 400 Minneapolis, MN 55431
Website URL: https://childrenscancer.org/awards/
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.