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Accelerating Impact for Hard-to-Treat Cancers Award

children's cancer research fund

Children’s Cancer Research Fund (CCRF) is a national nonprofit committed to finding safer, more effective therapies for kids battling cancer. Thanks to donors and partners around the country, we have contributed $235 million to research, education and awareness, and quality-of-life programs for childhood cancer families. We believe kids deserve safer, less toxic treatments, and we’re committed to funding groundbreaking research and services that enhance healing and care. With these research awards, we intend to support projects that enable the prevention, early detection, treatment, and improve outcomes of pediatric cancers that remain hard-to-treat.

Treatment success against hard-to-treat cancers has remained out of reach. This grant mechanism supports basic, clinical, and population studies. Projects may include pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

For this funding opportunity, hard-to-treat cancer is defined as 5-year survival less than 70% in an individual cancer (e.g. osteosarcoma, AML, DIPG), in a cancer with unfavorable behavior (e.g. relapse or metastasis), or in a molecular defined subtype (e.g. MLL rearranged leukemia, PAX3- FOXO1 rearranged RMS). Cancers with survival <70% in demographic groups defined by age, sex, or race/ethnicity may also qualify if a biologic hypothesis is being pursued.

Applicants must demonstrate that the cancer(s) they propose to study is consistent with this definition of "hard-to-treat" and with the scientific literature.

Specialties

Cancer

Pediatrics

Oncology

Eligibility Requirements

Any nonprofit research institution based in the U.S. is eligible to apply. An applicant institution should have appropriate resources and infrastructure to support the proposed research, including:

• Adequate facilities and services to manage the award.

• Fiscal and grants management infrastructure to support policies including protection for human and animal subjects (e.g., a sponsored projects office or contract with an IRB or IACUC).

• Human subjects or IACUC approval is required as a condition of grant funding.

To signify agreement with grant policies, an application must be signed by an authorizing official of the institution. The institution is responsible for verifying that all documentation related to the application and grant is correct, including all representations made by any named research (e.g., position or title).

The institution is responsible for immediately reporting to CCRF any action including recertification, loss certification, breach of contract, misconduct, or change in employment status for a named researcher with the institution. This includes PI administrative leave, which may occur during the term of any award pertinent to the work described in the grant application.

Applicants must carefully review the funding announcement instructions and complete all required materials using the specified templates and forms. Non-compliance with the provided instructions may lead to administrative rejection of the application. Additionally, failure to adhere to these terms or any other CCRF policies or procedures may result in the suspension or cancellation of the grant, at CCRF's sole discretion.

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: children's cancer research fund

Sponsor Type: Corporate

Address: 7301 Ohms Lane, Suite 355 Minneapolis, MN 55439 USA

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