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Chemoresistance in Human Tumors and Nanomedicine-based Therapies

National and Kapodistrian University of Athens Greece

The research focuses on understanding the molecular basis of chemoresistance and immune-resistance in human tumors, the onset and therapeutic responses of inflammatory bowel diseases through genomics and metagenomics, and the development and validation of innovative nanomedicine therapies, including metallic, bi-metallic, liposomes, polymers, and hybrid systems.

Main Areas of Interest

Chemoresistance/Immune-resistance in Human Tumors: Explore the molecular basis of the onset and reversion of chemoresistance.
Molecular basis of Inflammatory Bowel Diseases: Explore the molecular basis of the onset of the disease and response to therapies based on genomics and metagenomics
Nanomedicine-based Therapies: Engage in the synthesis and validation of novel nanomedicine therapies (metallic, bi-metalic, liposomes, polymers, hybrid systems).

Maria Gazouli, a biologist, is a Professor of Biology – Nanomedicine at the Department of Biology at the National & Kapodistrian University of Athens (NKUA), School of Medicine. She completed her first PhD training at the Department of Biology, School of Science of NKUA, in partnership with the Hellenic Pasteur Institute, and her second PhD training at the Department of Microbiology, School of Medicine of NKUA. She conducted her postdoctoral work in the USA at the Cell Biology and Pharmacology Department, Georgetown University Medical Center, Washington DC. From 2000 to 2001, Dr. Gazouli was a Research Fellow at NCSR Demokritos, Institute of Biology, and from 2001 to 2003, she was a Research Fellow at the Department of Histology – Embryology, School of Medicine, NKUA. From 2004 to 2006, she served as a technical scientific staff member at the Laboratory of Biology, School of Medicine, NKUA. In 2007, she joined the NKUA Medical School as a Lecturer of Biology. In 2012, she was promoted to Assistant Professor of Molecular Biology, in 2016 to Associate Professor of Molecular Biology, and in 2020 to Professor of Biology – Genetics - Nanomedicine.

Dr. Gazouli's work primarily focuses on the molecular basis of diseases, particularly autoimmune diseases and cancer, as well as the molecular detection of pathogens and the investigation of the pathogenesis of the diseases they cause in humans. Recently, she has incorporated nanotechnology to target cancer detection, imaging, and drug delivery. She was honored with a Fulbright Scholarship for the development of nanotechnology-based biosensor arrays for the detection of circulating colorectal cancer cells at the University of Maryland, College Park, MD, USA.

Dr. Gazouli's work is reflected in over 350 publications that have received more than 15,800 citations, with an h-index of 64 (Google Scholar, 1/1/2024). She holds one granted international patent and three European patents. She has delivered more than 60 invited lectures at international and national conferences and universities and has trained several junior scientists. Dr. Gazouli has served as an ad hoc reviewer for various scientific journals and as an expert evaluator for national and international research grant funding agencies. She has been the scientific coordinator of European Commission-funded collaborative research programs. Dr. Gazouli teaches Biology, Genetics, and Nanomedicine to undergraduate medical students and in master's programs. Currently, she is a National Representative at the Committee of Advanced Therapies (CAT) of the European Medicine Association.

Techniques You Will Learn

Advanced Cell Culture Techniques: Gain hands-on experience in 2D and 3D cell culture using various cell types.
Molecular and Cellular Biology: Master techniques such as gene silencing, overexpression, cell viability/toxicity assays, and cell metabolism assays.
Immunoblotting: Learn and apply immunoblotting.
Genetic Analysis: Conduct qualitative and quantitative PCR, PCR-arrays
Immunological and Microscopy Techniques: Develop skills in ELISA, flow cytometry, fluorescence/confocal microscopy, and immunohistochemistry.
Oncological Mouse Models: Experience handling immunocompetent mouse models for various cancers, monitoring tumor progression, and analyzing immune system activity.
Drug encapsulation: Experience on drug encapsulation on nanosystems, drug delivery studies, toxicity studies and genetic pathways influenced

Curriculum

Expertships (1-week Program): Ideal for initial engagement, this program focuses on meeting with the mentor, exploring potential collaborations, and understanding the research environment. It's an excellent opportunity for planning future research projects and collaborations.
2-week Program: This program offers a brief yet insightful experience into our research areas. It's suited for those seeking an introduction to our research methodologies and lab environment, bridging the gap between initial exploration and in-depth research training.
Intensive Research Training (6-12 Weeks): For a comprehensive and immersive experience in research techniques, the 6–12-week programs are recommended. These programs provide extensive hands-on training, allowing for deep involvement in our research areas and experimental techniques.

Accommodation

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.

Who Can Apply

All

Host Details

Host Name: Maria Gazouli

Affiliation: National and Kapodistrian University of Athens Greece

Address: National and Kapodistrian University of Athens Greece

Website URL: https://en.uoa.gr/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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