Trialect

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Cannabinoid-based molecules for Onco-Metabolic and Neurodegenerative Therapy

Institute of Biomolecular Chemistry, National Research Council of Italy

Main Areas of Interest

Developing novel cannabinoid-based therapies for onco-metabolic and neurodegenerative diseases
Identifying multi-modal molecules that selectively target the endocannabinoid system
Validation of new combinatorial cannabinoid-based antitumor therapies
Elucidating the role of mitochondrial dysfunction in various pathological contexts, particularly its connection to cannabinoid receptors

Specialties

Oncology

Molecular Biology

Cancer

Techniques You Will Learn

High-Resolution Respirometry: To assess mitochondrial function, oxygen consumption rates (OCR), and metabolic activity in cells and tissues.
Western Blotting and Immunohistochemistry: For protein expression analysis and receptor localization in tissues and cells.
Flow Cytometry and FACS: To analyze cell populations, apoptosis, proliferation, and receptor expression.
Confocal Microscopy: For detailed visualization of cellular structures, receptor distribution, and mitochondrial dynamics.
qRT-PCR: To investigate gene expression profiles and identify pathways modulated by cannabinoid-based therapies.
In Vitro and In Vivo Tumor Models: To evaluate antitumor efficacy, drug synergy, and the impact of combinatorial therapies.
3D Cell Culture Systems: To create physiologically relevant tumor models.
Omics Approaches (Proteomics, Metabolomics, Lipidomics): To uncover systemic effects of cannabinoids and their impact on cellular metabolism.

Curriculum

Fellowship Program Curriculum (6-12 weeks)

Induction and Orientation:

Support provided to help fellows settle comfortably into their new environment, including assistance with accommodation, local amenities, and registration at the CNR-ICB guest register.

Allocation of a dedicated workspace.

Comprehensive induction covering safety, laboratory practices, and personal welfare, provided by university staff and the supervisor.

Training and Experimentation:

Initial meeting to outline training objectives and establish experimental plans with realistic timelines.

Full practical training on each experimental technique, including supervised initial runs.

Continuous support and interaction with the supervisor and lab members for protocol clarification, laboratory procedures, and data interpretation.

Maintenance of detailed and accurate records in a provided laboratory notebook.

Progress Monitoring:

Scheduled weekly or bi-weekly meetings to discuss progress, reflect on outcomes, and plan subsequent experiments based on generated data.

Academic and Professional Development:

Active participation in research group meetings and relevant academic activities within the school and university.

Encouragement to present research findings orally at a research group meeting before the fellowship concludes.

Attendance at targeted workshops on research career development topics such as manuscript writing, grant writing, and networking.

Dissemination and Future Planning:

Guidance provided for publishing research findings or presenting at conferences.

Individual support in identifying future professional or research opportunities enabled by the fellowship training, and integrating acquired skills into further career paths.

Personalized Support:

Throughout the fellowship, any unique challenges or specific requests will be fully considered to ensure a personalized, responsive, and effective training experience.

Accommodation

Try Airbnb.com

####Guest house/accommodation near the lab (10 minutes walking)

Miramare Residence
- website: http://www.miramareresidence.com/en/
Hotel Santa Marta:
- website: http://www.santamartahotel.it/it
Hotel La Tripergola:
-website: http://www.latripergola.it/en
Hotel Gauro
-website: http://www.hotelgauro.it/
Hotel Villa Luisa:
-website: http://www.villaluisaresort.it/en/
B&B O’Chalet
-website: http://www.bbochalet.com/
Neronensis Relais & Spa
-website: https://www.airbnb.it/rooms/21776567

Fees and Program Logistics

This program has the following durations available:

Duration	Fee
2 weeks	$875.00
6 weeks	$1,500.00
12 weeks	$2,750.00

This program allows Merit Applications. This program allows merit-based applications for virtual and onsite clinical and research programs. If you are successfully awarded under this category, Trialect or the host mentor will cover the tuition fee only. All applications will be evaluated based on merit. Due to the high level of competition, the chances of being selected under the merit category are quite limited.

Who Can Apply

Physicians and scientists from around the world are invited to apply

Host Details

Host Name: Alessia Ligresti

Affiliation: Institute of Biomolecular Chemistry, National Research Council of Italy

Address: Via Campi Flegrei 34, 80078 Pozzuoli (Na), Italy

Website URL: http://www.icb.cnr.it/en/

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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