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Research Grant on Prevention and Early Detection in Lung Cancer
Lung cancer continues to be the number one cause of cancer deaths in the United States and worldwide, accounting for an estimated 125,070 deaths annually in the United States alone1 . When detected at an early stage (Stage I), the prognosis is good for most patients. The current standard for detecting lung cancer is low dose computed tomography (LDCT), with follow-up confirmation via biopsy. The U.S. Preventive Services Task Force (USPSTF) updated its recommendations in 20212 to include annual LDCT screening for patients who are 50-80 years of age, have a 20 pack-year smoking history, and are either a current smoker or have quit within the past 15 years. While this has increased the number of people eligible for screening, it is still limited to people with a smoking history. Given the significance of and need for early detection of lung cancer and advancements in molecular screening, LCRF continues this mechanism to support research projects that facilitate prevention or approaches for early detection of lung cancer. Work supported through this mechanism addresses important questions in non-small cell and small cell lung cancer.
This funding mechanism is focused on identifying, characterizing, and developing approaches and techniques that will allow early detection and/or prevention of lung cancer and gaining insight into pre-neoplastic processes in the lungs. The ultimate goal is to detect lung cancer at the earliest stages and subsequently increase survival and survivorship. While this list is not exclusive, general areas of interest include:
• Improvements in risk stratification of patients and uptake for screening
• Identification and characterization of new biomarkers for NSCLC and SCLC • Development of predictive, diagnostic, or prognostic biomarkers
• Liquid biopsy assays and related techniques
• Genomic and histological approaches to improve early detection in tissue samples
• Novel imaging and computational modalities to identify and risk stratify pre-neoplastic lesions
• Implementation science with systematic uptake of evidence-based research findings into routine practices to improve quality and effectiveness of health services for early detection
• Studies of pre-neoplasia and progression to lung neoplasia to inform prevention strategies
• Development of pathways to increase uptake and utilization of lung cancer screening
• Epidemiology studies to identify risk factors and implementation of prevention measures
• Development of any new technologies that will aid in identifying early-stage lung cancers
Budget Requirements
The maximum award amount is $150,000 for a period of two years (disbursed at $75,000 per year). Additional budget requirements and considerations include the following:
• Funding from this award may not be used to support institutional indirect / facilities and administrative costs.
• The LCRF grant must be the primary source of support for the project. Additional secondary funding (e.g. for core services support) is permitted.
• There is no limit on the amount of salary support that may be requested. However, appropriate justification for all budget items is required. Any salary requests in excess of 20% of the total budget must be explicitly justified. Queries related to justification should be sent to LCRF at least a week before submission deadline.
• Any equipment costs must be limited and directly applicable to the research project (i.e. large, general equipment costs are not permitted).
• Direct patient care costs reimbursable by other sources may not be included.
• Travel and publication costs are permitted.
Specialties
Eligibility Requirements
Investigators must be affiliated with a non-profit academic or research institution and must be post-doctoral researchers, clinical fellows, or early-career and mid-career investigators with less than ten years’ experience since their initial faculty appointment.
Applicants from US-based and international institutions are eligible to apply and may hold any residency/citizenship status. Applicants are prohibited from applying if they have received funding from the LCRF within the last 4 years. Applicants are prohibited from applying in more than one of LCRF’s funding tracks in the same cycle. Senior investigators with more than ten years’ experience since faculty appointment are generally not eligible for funding and are encouraged to mentor a junior team member through the application process. However, exceptions will be made for investigators with more than ten years’ experience in other disease areas or topics. Ineligible investigators with these or other special circumstances may request review by contacting the LCRF grants office (see Inquiries section below) before submitting an application and at least a week before submission deadline. Ineligible applications and new requests under special circumstances will not be considered after submission deadline.
Sponsor Details
Sponsor Institute/Organizations: Lung Cancer Research Foundation
Sponsor Type:
Address: 501 7th Avenue, Suite 401, New York, NY 10018, USA.
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Grant
Letter Of Intent Deadline:
Mar 03, 2025
Final Deadline:
Jun 02, 2025
Funding Amount:
$150,000
Host Details
Affiliation: Lung Cancer Research Foundation
Address: 501 7th Avenue, Suite 401, New York, NY 10018, USA.
Website URL: https://www.lungcancerresearchfoundation.org/wp-content/uploads/2025-LCRF-ED-RFP.pdf
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
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