The process of applying for funding for Research Grant starts with an applicant’s submission of an LOI through ProposalCentral between July 15, 2025 and September 3, 2025. On ProposalCentral, click ‘Apply Now’ to begin your LOI.
LOIs should have a direct application to Huntington’s disease. All LOIs related to Huntington’s disease are reviewed by a committee comprised of members of the SAB, who independently review and score each LOI. Only the LOIs that the SAB review committee considers the most impactful will have a full application requested.
HDF funds Research Grants at the post-graduate level. HDF grant and fellowship applicants must present a specific research plan. Please read the FAQs below before proceeding.
Grants provide more experienced researchers with seed funding to enable them to collect the preliminary data needed to obtain major, long-term funding from other organizations, including the National Institutes of Health. The Hereditary Disease Foundation awards one-year grants of $100,000. With (1) evidence of substantial progress and clear, compelling rationales for continuation; (2) a written request by the grantee for a one-year extension of the project as part of the grant progress report; and (3) competitive review by the HDF review committee, a subset of grants will be selected for the renewal for an additional year of funding of up to $100,000 (maximum possibility of one year renewal).
Letter of Intent Submission Dates
July 15, 2025 – September 3, 2025 (BY 11:59 PM ET)
Invitation to Submit Full Application
October 17, 2025
Application Deadline
December 2, 2025 (BY 11:59 PM ET)
Funding Decision
February, 2026
Start Date
March-April, 2026
All proposals must directly address HD mechanisms, biomarkers, disease modifiers, or therapeutic strategies.
LOIs are strictly screened for relevance—only the most compelling, HD-specific proposals move forward
Postdoctoral Fellowships:
2 years, $100K/year, for early-career scientists (≤7 years since PhD) committed full-time to HD research .
Requires a strong mentor letter.
Research Grants:
1-year, $100K for seed or pilot studies that generate data for larger funding
Career Advancement Grants:
Support transitioning postdocs to faculty in HD research.
Transformative Research Awards:
Multi-year, multi-million-dollar awards for high-risk, high-reward team science targeting new disease mechanisms .
A two-stage process:
LOI evaluated by the Scientific Advisory Board (SAB)—only HD-relevant, high-impact LOIs are invited to full application.
Full applications are reviewed by ≥3 experts with composite scoring; top proposals are discussed by the full SAB
Review criteria include:
Relevance, Novelty, Significance, Scientific Premise, Approach, Applicant Track Record, Environment, and Budget
Projects must include strong preliminary data, well-designed methodology (including power calculations), and rigorous experimental design.
Budgets must follow NIH-style formatting; no indirects (overhead costs are excluded)
Fellowships and Career Awards require a mentor letter vouching for scientific independence, and institutional commitment is evaluated under “Environment” criteria .
Applicants must have completed all progress reports on past grants before applying again
Postdoctoral Fellows must commit full-time effort to HDF-supported HD projects
HDF funds researchers worldwide and supports collaborative, transformative research that can reshape HD science or therapeutics
✅ Summary Table
Predictor | What to Do |
---|---|
HD-Specific Focus | Clearly address Huntington’s disease |
Career-Stage Fit | Apply to fellowships, grants, or awards appropriate to your career |
Data & Methods Rigor | Use pilot data, power calculations, and NIH design standards |
Strong Mentorship | Secure a mentor letter emphasizing independence |
Institutional Environment | Demonstrate support with resources and ethics |
Clean Reporting Record | Ensure all past grant reporting is up to date |
Budget Compliance | Use NIH styles and exclude indirect costs |
Two-Stage Excellence | Invest in both a strong LOI and full proposal |
🔧 Pro Tips
Start early — LOI deadlines are typically early September; full applications in December
Tailor your narrative — highlight why HD is the right model, include pilot data, and show collaborative potential.
Follow NIH formats — especially for budgets and biosketches.
Explain your HD-specific impact — show how your work could open new therapeutic avenues.
Collaborate — even solo grants benefit from highlighting multidisciplinary or multi-institutional input.
Address all review criteria — ensure you cover relevance, novelty, approach, applicant, environment, and budget.
Applicants with overdue progress reports will not be permitted to submit new grant proposals until all delinquent reports have been received and reviewed.
Sponsor Institute/Organizations: Hereditary Disease Foundation
Sponsor Type: Corporate/Non-Profit
Address: 601 West 168th Street, Suite 54 New York, NY 10032 T 212 928 2121 F 212 928 2172 cures@hdfoundation.org
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Sep 03, 2025
Dec 02, 2025
$100,000
Affiliation: Hereditary Disease Foundation
Address: 601 West 168th Street, Suite 54 New York, NY 10032 T 212 928 2121 F 212 928 2172 cures@hdfoundation.org
Website URL: https://hdfoundation.org/grant-and-postdoctoral-fellowship-application/#1716504542323-3629004c-b4a5
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
Commonly asked questions about this funding opportunity from the host and other attendees.