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Promoting Healthy Children and Youth Topical PCORI Funding Announcement -- Cycle 3 2024

Patient-Centered Outcomes Research Institute

This Topical PCORI funding announcement (PFA) seeks to fund high-quality patient-centered comparative clinical effectiveness research (CER) projects that focus on interventions that improve patient-centered outcomes in U.S. children and youth.

PCORI uses the World Health Organization’s definition of children and youth, defined as persons between 0 and 24 years of age. Children and youth comprise more than 30 percent of the population and are the most racially and ethnically diverse age group in the United States. Individuals within this population face multiple challenges to their mental and physical health as evidenced by increasing rates of depression, anxiety, obesity and deaths due to injuries and drug misuse. The promotion of health for this large and diverse population requires interventions across the care continuum including supporting optimal growth and development, screening and prevention, treatment of acute and chronic illnesses and the transition to adult care. Compared to adults, available choices of interventions for children and youth may be distinctive and varied based on their stage of physical, cognitive and emotional maturity. Multiple systems and external structures also influence child health, development and functioning, and can facilitate or impede successful health outcomes.

To increase evidence that addresses meaningful decisional dilemmas faced by patients, families, clinicians and other health and healthcare community members, this opportunity aims to fund CER studies that compare interventions across the care continuum to improve patient-centered outcomes in children and youth. Applications may propose comparative effectiveness studies of prevention, screening, diagnostic, treatment and management approaches, and pharmacologic, non-pharmacologic and/or combination therapies, as appropriate. Studies may also focus on improving system-level strategies delivered in hospitals, clinics or community settings to improve patient-centered outcomes.

This opportunity is open to research that involves children and youth (ages 0-24) and addresses interventions across various stages of healthcare, from prevention and screening to treatment and management.

Key eligibility restrictions include:

  • Projects should not primarily focus on developing or validating instruments.
  • Cost-effectiveness analysis using dollar-cost per quality-adjusted life-year (QALY) is not funded.
  • Comparisons based primarily on costs are not eligible.
  • Projects that do not engage patients or healthcare stakeholders in the research process are generally not considered, unless highly technical or methodological in nature​

Sponsor Institute/Organizations: Patient-Centered Outcomes Research Institute

Address: 1333 New Hampshire Avenue NW, Suite 1200 Washington, DC 20036

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View Funding Opportunity

Grant

Letter Of Intent Deadline:

Oct 01, 2024

Final Deadline:

Jan 14, 2025

Funding Amount:

$12,000,000

3 awards available. The funding amount can be up to $12 million over a maximum of five years.

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