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Primary Prevention of Cancer

Cancer Prevention and Research Institute of Texas

The Primary Prevention of Cancer RFA solicits applications for eligible projects up to 5 years in duration that will deliver multilevel, evidence-based interventions that improve cancer-related health behaviors, including improving the quality of life and cancer outcomes for cancer survivors. Interventions may address tobacco use, obesity, physical inactivity, unhealthy eating, alcohol use, HPV vaccination, hepatitis B vaccination, and environmental/occupational cancer exposures. Interventions focusing on cancer survivors that seek to prevent or mitigate long-term physical or psychological outcomes of cancer treatment are eligible. Nonmetropolitan (rural) and/or medically underserved populations must be included in the defined service area.

The following are required components of the project:

• Evidence-Based: CPRIT’s primary prevention grants are intended to fund culturally appropriate, effective, and efficient systems of delivery of preventive services based on the existing body of knowledge about and evidence for cancer prevention. Evidence-based and promising interventions can be identified via the Community Guide, What Works for Health, National Comprehensive Cancer Control Program, NCI Evidence-Based Cancer Control Programs, and other sources.

The National Comprehensive Cancer Network, American Cancer Society, and Children’s Oncology Group have developed consensus-based comprehensive survivorship care guidelines to provide direction on managing the potential physical and psychosocial longterm impact of cancer/associated treatment and subsequent surveillance for recurrence and screening for second primary cancers for projects focusing on survivor care. If evidence-based interventions have not been implemented or evaluated for the specific population or setting proposed, provide evidence that the proposed intervention is appropriate for the population and has a high likelihood of success (ie, an evidenceinformed practice). In cases where the evidence base is still developing, the applicant should provide a strong and comprehensive evaluation plan allowing for documentation of new evidence over the life of the project.

• Multilevel Interventions: Health behaviors have multiple levels of influences, often including individual, group, organization, and community determinants. Influences on behaviors interact across these different levels, and multilevel interventions are the most effective in changing behavior (See http://medbox.iiab.me/modules/encdc/www.cdc.gov/cancer/crccp/sem.htm).

• Geographic Area to be Served: Preventive service delivery to nonmetropolitan/medically underserved area (MUA) counties must be included in the defined service area. Rural and MUA counties may be identified via web-based tools from the Texas Department of State Health Services and US Department of Health and Human Services. Service to urban counties that are not medically underserved is allowable as long as the project proposes to also serve nonmetropolitan counties that are medically underserved.

• Community Partner Networks: Applicants are strongly encouraged to coordinate and describe a collaboration of preventive service providers and community partners that can deliver outreach, education, clinical, and navigation services to the most counties and the most people possible in a selected service region. Applicants should consider providing financial assistance to service providers for navigation services. Partnerships with other organizations that can support and leverage resources (eg, community-based organizations, local and voluntary agencies, nonprofit agencies, groups that represent priority populations) are encouraged. Letters of commitment or memoranda of understanding (MOUs) describing their specific role in the partnership will strengthen the application.

CPRIT expects measurable outcomes of supported activities, such as significant provision of evidence-based interventions to modify cancer risk factors, changes in provider practice, and systems changes. Applicants must demonstrate how these outcomes will ultimately impact incidence, mortality, morbidity, disparities, or quality of life. Under this RFA,

CPRIT will not consider the following:

• Projects focused solely on metropolitan/non-medically underserved counties.

• Projects focusing solely on education and/or outreach or solely on systems and/or policy change that do not include the navigation to and delivery of multilevel interventions to reduce cancer risk.

• Projects focusing solely on case management/patient navigation services. Case management/patient navigation services, including survivor care plans, must be paired with the delivery of a cancer prevention service, including those practices delivered by another provider.

• Cancer preventive services proposed as part of the project that do not comply with established and current national guidelines.

• Projects primarily focusing on cancer screening and early detection. Applicants interested in projects that are predominantly secondary cancer prevention but include some primary prevention interventions should apply under the Cancer Screening and Early Detection (CSD) mechanism. PPC projects may include some secondary prevention interventions if they are complementary to the proposed primary prevention intervention (eg, HPV vaccination with some cervical cancer screening) but must adhere to all requirements of the CSD mechanism.

• Projects involving prevention/intervention research. Applicants interested in prevention research should review CPRIT’s Academic Research RFAs

Specialties

Cancer

Eligibility Requirements

• The applicant must be a Texas-based entity, such as a community-based organization, health institution, government organization, public or private company, college or university, or academic health institution.

• The applicant is eligible solely for the grant mechanism specified by the RFA under which the grant application was submitted.

• The designated PD will be responsible for the overall performance of the funded project. The PD must have relevant education and management experience and must reside in Texas during the project performance time.

• The evaluation of the project must be headed by a professional who has demonstrated expertise in the field and who resides in Texas during the time that the project is conducted.

• The applicant may submit more than 1 application, but each application must be for distinctly different services without overlap in the services provided. Applicants who do not meet this criterion will have all applications administratively withdrawn without peer review.

• If an organization has a current CPRIT grant that is the same or similar to the prevention intervention being proposed, the applicant must explain how the projects are nonduplicative or complementary. Duplicative applications will be administratively withdrawn.

• Collaborations are permitted and encouraged, and collaborators may or may not reside in Texas. However, collaborators who do not reside in Texas are not eligible to receive CPRIT funds. Collaborators should have specific and well-defined roles. Subcontracting and collaborating organizations may include public, not-for-profit, and for-profit entities. Such entities may be located outside of the State of Texas, but non-Texas-based organizations are not eligible to receive CPRIT funds.

• An applicant is not eligible to receive a CPRIT grant award if the applicant PD, any senior member or key personnel listed on the grant application, or any officer or director of the grant applicant’s organization or institution is related to a CPRIT Oversight Committee member.

• An applicant organization is eligible to receive a grant award only if the applicant certifies that the applicant organization, including the PD, any senior member or key personnel listed on the grant application, or any officer or director of the grant applicant’s organization (or any person related to 1 or more of these individuals within the second degree of consanguinity or affinity), has not made and will not make a contribution to CPRIT or to any foundation created to benefit CPRIT.

• The applicant must report whether the applicant organization, the PD, or other individuals who contribute to the execution of the proposed project in a substantive, measurable way (whether slated to receive salary or compensation under the grant award or not), are currently ineligible to receive federal grant funds because of scientific misconduct or fraud or have had a grant terminated for cause within 5 years prior to the submission date of the grant application.

• CPRIT grants will be awarded by contract to successful applicants. CPRIT grants are funded on a reimbursement-only basis. Certain contractual requirements are mandated by Texas law or by administrative rules. Although applicants need not demonstrate the ability to comply with these contractual requirements at the time the application is submitted, applicants should make themselves aware of these standards before submitting a grant application. Significant issues addressed by the CPRIT contract are listed in section 6. All statutory provisions and relevant administrative rules can be found on the CPRIT website.

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: Cancer Prevention and Research Institute of Texas

Sponsor Type: Corporate/Non-Profit

Address: 1701 North Congress Avenue, Suite 6-127 Austin, TX 78701 United States

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