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Pilot Award Program for Myelodysplastic Syndrome Research

Taub (Henry and Marilyn) Foundation

The Henry and Marilyn Taub Foundation (HMTF) 2025 Pilot award will provide seed money to pursue transformative ideas that can forge new scientific directions and strategies in MDS research. The one-year award provides $100,000 for proof-of-concept studies addressing critical roadblocks to understanding MDS and its treatment. Successful projects will generate preliminary data needed to support their extension and expansion through other funding mechanisms. The research must be non-incremental and may include high-risk/high-reward or collaborative efforts to incorporate new technologies and approaches from other fields.

The Henry and Marilyn Taub Foundation (HMTF) is a family foundation located in Bergen County, New Jersey. For over 50 years, HMTF has been making grants to advance its philanthropic interests in the areas of medical research, education, strengthening local communities and Jewish life. The HMTF Grants Program for Myelodysplastic Syndromes (MDS) Research ran from 2014-2023, supporting high-impact translational research to understand the underlying causes of MDS and to advance its treatment and prevention. The 2025 HMTF Pilot Awards provides a grant mechanism to specifically explore new and big ideas in MDS research that have break-through potential but are at early stages of development and are unlikely to receive support from conventional funding sources due to the lack preliminary data.

Program Overview:

While relatively short in duration, pilot awards represent a class of grants providing seed money to test novel, ground-breaking ideas and generate preliminary data typically needed for support through conventional grant mechanisms. The new 2025 HMTF Pilot Award provides $100,000.00 over one-year with the goal of exploring untested strategies and disruptive new ideas. These one-year proof-of-concept studies represent new and conceptually innovative ideas that can include high-risk/high-reward projects and encourage collaborative efforts that bring in new concepts, technologies and strategies from other fields. Research must be non-incremental and not extensions of current lines of study. If successful, the data from these pilot studies will generate critical preliminary data and serve as an onramp for their continued pursuit through more conventional grant opportunities.

Grant Cycle and Fund Use:

One-year, $100,000 (2 x $50K) awards will run between December 1, 2025 – November 30, 2026. Indirect costs will NOT be covered by this award.

Funds may be used for personnel salaries, supplies, small equipment, and/or research-related services only. Funds may not be applied to research costs covered by other sources. Funds up to $2500 may be allocated to attend and present results at relevant in-person scientific meetings.

AI Based Application Success Predictor

1. Move past proofs-of-concept into truly transformative/innovative ideas**

The Foundation funds proof-of-concept studies in MDS with high‑risk, high-reward aims—not incremental extensions of existing lines .

Successful applicants propose disruptive ideas, often collaborating across disciplines or applying new technologies to MDS .

🧬 2. Early-career, independent investigators with faculty appointments

Applicants must hold an MD/PhD (or equivalent) and an independent faculty appointment (Assistant Professor or higher) at a U.S. nonprofit institution, with institutional lab space .

It targets early-career, independent investigators, promoting young researchers launching new directions .

🧪 3. Pilot studies catalyzing larger-scale future funding

The $100K one-year award is explicitly meant to produce preliminary data to support future external funding (e.g. NIH, DoD) .

Projects that clearly outline follow-on grant plans tend to stand out.

🤝 4. Translational focus & cross-disciplinary collaboration

Research may leverage technologies or methods from outside MDS (e.g. bioinformatics, systems biology, immunology) .

Collaboration beyond traditional MDS lines signals innovation and risk-taking.

🏛️ 5. U.S.-based nonprofit academic institutions only

Eligible organizations must be U.S.-based nonprofit universities, colleges, hospitals, or research labs; no industry or international entities

Foundations don’t accept unsolicited proposals—they pre-select institutions and run targeted award cycles .

✅ Application Tips for Higher Success

Area	What to Strengthen
Novelty & Innovation	Emphasize non-incremental ideas and high-risk, high-impact potential.
Preliminary Data Plan	Show clear strategies to generate publishable, fundable data within 12 months.
Translational Pathway	Outline follow-up funding goals (e.g. NIH R01), and real-world MDS relevance.
Cross‑Disciplinary Team	Collaborate with experts from other fields to bring fresh methods to MDS.
Institutional Readiness	Confirm lab space, startup support, and infrastructure at your institution.
Eligibility & Formatting	Ensure federal faculty appointment, nonprofit U.S. institution, and adhere strictly to LOI/full proposal guidelines (e.g. March 10 LOI for 2025) .

⚙️ Why These Predictors Matter

Foundation strategy: They've pivoted toward targeted pilot grants for MDS—seed grants that incubate bold science .

Track record: Funded 2014–2023, consistently supporting early-stage, high-reward translational research .

Focused mission: By funding pre-selected institutions and not accepting unsolicited proposals, they streamline toward measurable, strategic impact .

🧭 Final Takeaway

To maximize your chances:

Propose radical, high-impact ideas within MDS.

Be an early-career investigator with faculty standing at a U.S. nonprofit.

Have structural plans to generate preliminary data that launch future funding.

Emphasize translational impact and interdisciplinary collaboration.

Confirm institutional support and eligibility, and tighten adherence to their deadlines and formatting.

Specialties

Others

Eligibility Requirements

The award supports diversity and is dedicated to promoting independent early-career investigators. To foster innovation and the expansion of MDS research, collaborative efforts with those from non-MDS fields are encouraged. Do NOT apply unless you meet ALL of the Requirements and Research Criteria presented below.

An MD, PhD, MD/PhD or equivalent degree is required.
At the time of funding applicants must have a faculty appointment in the United States (instructor, assistant professor and above) with institution-designated laboratory space.
Eligible organizations include non-profit public or private institutions, such as universities, colleges, hospitals, and laboratories in the United States.
Neither United States citizenship or visa documentation is required.
Applications from biotech, pharmaceutical and other for-profit industries are NOT eligible.
Applicants must have the skills, knowledge, resources and infrastructure necessary to carry out the proposed research at their institution.
Only one application per Principal Investigator is allowed.

Research Criteria:

1. The HMTF Pilot Award focuses specifically on non-incremental lines of inquiry based on novel and conceptually innovative ideas.
2. This program supports transformative basic and translational research focused specifically on MDS, exclusive of AML and MPN.
3. Clinical studies are outside of the program scope and timeframe.
4. MDS as defined by the World Health Organization (WHO), including CMML and JMML, are considered within the scope of research supported by the Taub Foundation.
5. Proposals studying the progression of MDS to AML may be within the scope of this funding, however, research primarily focused on AML, MPN or other malignancies is discouraged and all projects must be clearly relevant to MDS.

Sponsor Details

Sponsor Institute/Organizations: Taub (Henry and Marilyn) Foundation

Sponsor Type: Corporate/Non-Profit

Address: 300 Frank W. Burr Boulevard – 7th Floor, Teaneck, NJ 07666

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