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Funding Opportunity




  Not Verified

Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement

Patient-Centered Outcomes Research Institute

This PCORI Funding Announcement (PFA) invites applications for high-quality patient-centered comparative clinical effectiveness research (CER) projects that will address critical decisions faced by patients, families, caregivers, clinicians, and the health and healthcare community and for which there is insufficient evidence.

Investigators must propose an individual-level or cluster randomized controlled trial of significant scale and scope for this PFA. The proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions. Proposed studies should compare interventions that already have robust evidence of efficacy and are in current use. If efficacy is not well established, then widespread use must be documented. Clinical interventions (such as medications, diagnostic tests, or procedures) and delivery system interventions (such as workforce, technologies and healthcare service delivery designs) are appropriate for these studies.

This funding opportunity anticipates that proposed research projects will require two phases of funding. The initial phase of funding supports a distinct feasibility phase intended for purposes of study refinement, infrastructure establishment, patient and stakeholder engagement, and feasibility testing of study operations, including the ability to recruit, enroll, and randomize participants successfully. Using the feasibility phase to establish evidence of an intervention’s efficacy or effect size is not permitted. Approval to proceed to the second phase will be contingent on achieving specific milestones and deliverables established for the feasibility phase.   

Key Dates

  • PCORI Online Opens
    April 1, 2025
  • Applicant Town Hall
    View slides/recording
  • Letter of Intent (LOI) Deadline
    May 13, 2025; 5 pm (ET)
  • LOI Status Notification
    June 10, 2025
  • Application Deadline
    Sept. 3, 2025; 5 pm (ET)

Budget and Duration

Investigators may request up to $2 million in direct costs for a feasibility phase up to 18 months in duration, with up to $20 million in direct costs for continuation to a full-scale study phase up to five years in duration. Total direct costs for the full proposal should not exceed $22 million.

 

PCORI is seeking to fund proposals that address critical decisions faced by patients, caregivers, clinicians, and stakeholders across the health and health care community and for which there is insufficient evidence. The proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions. They should also compare interventions that already have robust evidence of efficacy and are in current use.

Sponsor Institute/Organizations: Patient-Centered Outcomes Research Institute

Sponsor Type: Corporate/Non-Profit

Address: 1333 New Hampshire Avenue NW, Suite 1200 Washington, DC 20036 Phone: (202) 827-7700 | Fax: (202) 355-9558 info@pcori.org

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Grant, Award

Letter Of Intent Deadline:

May 13, 2025

Final Deadline:

Sep 03, 2025

Funding Amount:

$22,000,000

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