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Neuroimaging and CSF Biomarker Development Program

Alzheimer's Drug Discovery Foundation

The aim of this RFP is to further develop and validate established biomarkers for which there is a clear clinical need in Alzheimer's disease and related dementias. This RFP prioritizes biomarkers with a defined context of use, a clear advantage over other relevant biomarkers, and a path to commercialization and/or clinical use.

Specifically, this RFP focuses on:

Developing novel PET ligands for clinical trials
Supporting novel CSF biomarkers
Validating innovative MRI approaches in larger cohorts
Developing novel measures of functional activity such as EEG

Peripheral biofluids and digital/ocular approaches are supported through the Diagnostics Accelerator RFP.

Novel biomarkers of neuroinflammation, synaptic integrity, autophagy and TDP-43 are high priority. Other target areas of interest include:

Neuronal loss
Vascular injury and blood-brain barrier integrity
Mitochondria and metabolic function
Protein misfolding
Oxidative stress
White matter changes
Lewy body dementia
Other novel targets supported by compelling biological rationale and connection to disease

The ADDF has limited interest in CSF measures of amyloid and tau.

Must be received by 5:00 pm ET on the deadline date.

Letter of Intent
Date has passed.

Invited Full Proposal
April 21, 2025

Letter of Intent
September 15, 2025

Invited Full Proposal
November 17, 2025

AWARD INFORMATION

Awad Amount
Up to $600,000 based on stage and scope of research.

Award Duration
One year with potential for follow-on funding.

Allowable costs
Only direct costs are allowed.

Specialties

Clinical Trials

Others

Eligibility Requirements

Funding is open to researchers and clinicians worldwide at:

Academic medical centers and universities or nonprofits. Industry partnerships are encouraged.
Biotechnology companies. Existing companies and new startups are both eligible.
NOTE: Funding is provided through mission-related investments that require return on investment based upon scientific and/or business milestones

Sponsor Details

Sponsor Institute/Organizations: Alzheimer's Drug Discovery Foundation

Address: 57 West 57th Street, Suite 904 New York, NY 10019 info@alzdiscovery.org 212.901.8000

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