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NBDF-Sanofi Career Development Award

National Bleeding Disorders Foundation

The NBDF-Sanofi Career Development Award (CDA) is generously sponsored by Sanofi. NBDF seeks research grant applications from established investigators, preferably at the assistant professor level or above, who have demonstrated a commitment to bleeding disorders research. We especially encourage innovative projects that promote the development of novel technologies and/or therapies to advance the field of bleeding disorders research.

Funding

NBDF will award up to $70,000 annually for a maximum of three years.

Scope of Research

NBDF is interested in funding innovative research studies in bleeding disorders to be carried out at the sub cellular, cellular, animal or human/patient levels.

While gene therapy has been an approach which has shown much promise in hemophilia, no one method has been demonstrated to be superior. Multiple experimental strategies may be undertaken to help find a “cure” for bleeding disorders. NBDF is seeking research proposals on the nature, propagation, and use of hematopoietic, liver, or stem cells as an approach for gene transfer in hemophilia or for other novel approaches for treating bleeding disorders.

Studies to evaluate the genetic and immunologic bases for inhibitor development may lead to strategies to circumvent this potential complication of clotting factor replacement and/or gene transfer. This research could provide the opportunity to determine the prognostic indicators that place patients at risk of inhibitor development. Inhibitor research may also lead to the development of synthetic replacement factor and gene therapy products with decreased immunogenicity. This includes research on genotype/phenotype relationships and susceptibility to inhibitors.

Structural studies of clotting factor proteins are needed in order to design more efficacious, longer-lived clotting factor proteins. Development of both small, biologically active, orally delivered molecules and improved protein delivery systems represent strategies that could lead to advances in our understanding of bleeding disorders. Better functional assays for clotting factor proteins are also needed. Reproducible, low-volume measure of factor VIII and factor IX activity in different animal models would greatly facilitate validation of in vivo gene therapy studies as well as innovative alternative treatment strategies.

All CDA research proposals are subjected to a rigorous peer review process. Applications will be reviewed on scientific merit and scored in terms of project significance, scientific approach, innovation, investigator qualifications and institutional environment.

AI Based Application Success Predictor

1. Alignment with NBDF’s Research Mission

Projects must center on inheritable bleeding disorders (e.g., hemophilia, von Willebrand disease) and address clinical or translational gaps—basic science and clinical care are both eligible

Nursing and clinical Excellence Awards focus on outcome-related data, pathways, service utilization, rehab, psychosocial and women’s health dimensions .

🧪 2. Career Stage–Targeted Programs

Judith Graham Pool (JGP) Postdoctoral Fellowships support early-career researchers (PhD/MD) in hematology/genetics with 2 years of funding at ~$52K/year .

Excellence Awards (Nursing, PT, Social Work) support clinicians in treatment centers with one-year awards of ~$15K, promoting clinical research capacity .

📊 3. Peer-Reviewed Rigor & Evaluation Criteria

Applications are assessed by both scientific and lay reviewers, using criteria like significance, innovation, investigator qualifications, research approach, and environment .

Final approval comes from the NBDF Medical & Scientific Advisory Council and board .

🎯 4. Feasible, Well-Designed Projects with Clinical Focus

Proposals must include clear hypotheses, methods, timelines, and measurable outcomes.

Clinician-focused awards often emphasize care pathways, measurable outcome tools, service use, and multidisciplinary collaboration .

🤝 5. Multidisciplinary & Treatment Center Collaboration

Excellence fellowships encourage combined efforts—e.g., nursing and PT or social work—often across multiple hemophilia treatment centers .

Team-based applications are viewed favorably.

🏥 6. Investigator & Institutional Support

For postdocs: strong advisor endorsement, research training plan, and institutional backing are essential.

Clinical applicants must demonstrate relationships with HTCs and appropriate clinical settings

💡 7. Innovation within Practical Constraints

Both award types support novel care models or scientific studies, but within budget limits ($15–52 K) and short timelines (12–24 months).

Innovation can come from study design, care delivery, or multidisciplinary coaching.

✅ Summary Table

Predictor	Why It Matters
Mission alignment	Funding targeted at bleeding disorders research or clinical care
Appropriate program match	Postdoc vs. clinician-focused awards
Review rigor	Peer review by scientists and laypersons ensures relevance and quality
Scientific/clinical design	Well-defined hypotheses, methods, and measurable outcomes
Collaboration & treatment center links	Demonstrates feasibility and team support
Investigator strength	Strong track record, mentorship, or institutional backing
Budget-fit innovation	Clear, novel ideas within award limitations

💡 Tips to Strengthen Your Proposal

Target the right award track—postdoc fellowship vs. clinical Excellence Award.

Craft a clear study plan—with objectives, methods, metrics, timeline, and budget.

Engage multidisciplinary teams and multiple treatment centers for clinical projects.

Secure strong endorsement—particularly for postdoc advisors or HTC directors.

Highlight outcome measures—relevance to patients and bleeding disorders care.

Emphasize practical innovation—e.g., care pathway redesign or novel outcome tool.

Be budget-conscious—funding is modest, so align every cost with aims.

Address review criteria—pitch significance, rigor, investigator quality, environment, and innovation clearly.

Specialties

Hematology

Eligibility Requirements

Career Development Award (CDA) candidates must hold a MD, PhD, or equivalent degree, with no more than six years of postdoctoral years of experience in hematology, nor more than six years since completion of medical training. United States citizenship is not required, but applicants must be affiliated with or be faculty members of a U.S.-based organization such as - universities, colleges, hospitals or laboratories. Only non-commercial institutions and investigators associated with a non-commercial institution are eligible to apply for this award.

The CDA award recipient will be expected to spend at least 75% of their working time on the funded research project. The CDA recipient and his/her mentor are also expected to remain at their institution for the duration of the project. For the application, letters of support from appropriate institutional officials (department chair and financial grants officer) indicating the institution’s commitment to allow the candidate to focus his/her efforts on the stated research project will be required.

Sponsor Details

Sponsor Institute/Organizations: National Bleeding Disorders Foundation

Sponsor Type: Corporate/Non-Profit

Address: National Bleeding Disorders Foundation

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