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Multi-Purpose Micro-Physiological Systems

Merck KGaA

Ensuring the safety and efficacy of new drugs is critical to delivering impactful therapies that benefit patients. To achieve this, billions of dollars are spent annually by the pharmaceutical industry to bring a novel drug to the market. One of the key reasons for these inefficiencies is the poor translatability of the models currently used for predicting drug toxicity, ADME properties and efficacy during the pre-clinical phase. Indeed, underlying gaps and discrepancies between the biology of in vitro assays and in vivoanimal models with the clinical reality of patients' physiopathology has led to inaccurate selection and prioritization of compound development.

At Merck we are working to develop world class human-based MicroPhysiological Systems (MPS) that can materially improve translatability and reduce the usage of animals in the testing of drug and chemical compounds. We invite innovative research proposals that will join us in this transformative journey to redefine the predictability of drug safety and efficacy to bring better life-changing drugs to patients.

We are particularly interested in:

Novel development of Cardiac, Brain (including Blood-Brain Barrier), and Lung models, both iPSC and Patient Derived Organoid based
Applications including but extending beyond toxicology to include absorption, distribution, metabolism, and excretion (ADME) as well as efficacy models (specifically in relation to Oncology and Neuroinflammation diseases).
AI model development of human-based MPS systems using data from existing MPS models and/or newly developed MPS models

Specialties

Artificial Intelligence

Drug Delivery

Pharmaceuticals

Technology Development

Biomedical Engineering

Medical Devices

Pharmacology

Eligibility Requirements

Submitted proposals should include descriptions of:

Your existing demonstrated capabilities in your proposed research grant area utilizing MPS technology
The potential for significant impact in drug development or disease modeling
Your research should be suitable for potential publication in a peer-reviewed journals

Sponsor Details

Sponsor Institute/Organizations: Merck KGaA

Sponsor Type:

Address: Merck KGaA, Frankfurter Strasse 250 Darmstadt, 64293, Germany

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