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Gap Fund for early-stage development of new healthcare interventions
You can apply for academically led translational projects that aim to undertake a focused package of work that will bridge the gap between the inception of a new idea and substantive funding through schemes such as the MRC Developmental Pathway Funding Scheme to:
- help prevent disease
- help improve speed and accuracy of diagnosis of disease
- develop new treatments for disease
- help to improve outcome monitoring of patients receiving treatment
- help to improve the management of diseases and conditions
All human diseases and medical interventions are eligible for support, both in the context of UK healthcare and addressing global health issues.
Your project should have already explored a new concept and generated some data in support of the approach. Your application should clearly articulate:
- the core concept of the project
- the critical gap that needs to be addressed
- an explanation of how the proposed plan will address this critical gap
- the challenges and issues involved in onward development
This fund will provide small scale funding to generate critical data needed prior to seeking more substantive funding. A non-exhaustive list of examples of the types of projects that could be supported include:
- elements of therapeutic discovery, quantification, and validation
- development of an initial prototype
- early prototype testing
- initial biomarker validation
- vector identification or optimisation
- hit expansion medicinal chemistry
In exceptional circumstances, you can submit follow on applications where you can justify the need for continued support. However, in most cases a positive outcome of the proposed work should be sufficient to allow submission of a longer and larger application, potentially to DPFS.
For more information on the background of this funding opportunity, go to the ‘Additional information’ section.
Applications from research organisations who are not recipients of an MRC Impact Accelerator Account (IAA) award may use this funding opportunity to apply for more preliminary studies. The scale and scope of the request should reflect a project more in line with earlier stages of research.
Applicants should highlight within the application that they are applying for an IAA-like project and that their research organisation does not provide this opportunity.
Activities we support
You can apply for funding for work on novel:
- new small molecule medicines
- vaccines for infectious or non-infectious disease
- biologics (antibodies, peptides, proteins)
- advanced therapeutics (for example, gene therapy, cell therapy, RNA therapy, nucleic acid therapy and T-cell therapy)
- complex medicines for example PROTACS, molecular glues and antibody-drug conjugates
- regenerative medicine approaches
- repurposing clinical studies or using existing therapies for new indications
- medical devices
- digital healthcare, app development or artificial intelligence
- diagnostics (including biomarker validation)
- medical imaging technology
- surgical techniques or tools
- behavioural and psychological interventions
- radiotherapy and radiation protocols
Specialties
Eligibility Requirements
Who is eligible to apply
To be eligible to apply for this funding opportunity you must:
- be employed by an eligible research organisation
- show that you will direct the project and be actively engaged in the work
- be looking to generate critical preliminary data to build confidence in the development strategy for a new medicine, repurposed medicine, medical device, diagnostic test, or other medical intervention development
If you do not have a contract of employment for the duration of the proposed project, by submitting an application the research organisation is confirming, if it is successful:
- contracts will be extended beyond the end date of the project
- all necessary support for you and the project will be provided, including mentorship and career development for early career researchers
Who is not eligible to apply
You are not eligible to apply for this funding opportunity as a project lead if you are based at an international research organisation. This does not include MRC Unit The Gambia or MRC/UVRI Uganda Research Unit at the London School of Hygiene and Tropical Medicine that are eligible to apply as project lead. Before applying for funding, check the Eligibility of your organisation.
International applicants
You can include international applicants as project co-leads (international), where they will make a major intellectual contribution to the design or conduct of the project. The contribution and added value to the research collaboration should be clearly explained and justified in the application, see Applicant and team capability to deliver.
Equality, diversity and inclusion
We are committed to achieving equality of opportunity for all funding applicants. We encourage applications from a diverse range of researchers.
We support people to work in a way that suits their personal circumstances. This includes:
- career breaks
- support for people with caring responsibilities
- flexible working
- alternative working patterns
Sponsor Details
Sponsor Institute/Organizations: UK Research and Innovation
Address: UKRI, 1 ET, Polaris House, N Star Ave, Swindon SN2 1FL, United Kingdom
Grant
Letter Of Intent Deadline:
Nov 13, 2024
Final Deadline:
Nov 13, 2024
Funding Amount:
$393,960
5 awards available. Award range: £50,000 - £300,000
Host Details
Affiliation: UK Research and Innovation
Address: UKRI, 1 ET, Polaris House, N Star Ave, Swindon SN2 1FL, United Kingdom
Website URL: https://www.ukri.org/opportunity/funding-for-early-stage-development-of-new-healthcare-interventions/
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
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