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Experimental medicine stage one
Apply for funding to investigate the causes, progression and treatment of human disease.
Your project must:
- include an experimental intervention or challenge in humans
- focus on a mechanistic hypothesis
- be academically-led
You must be based at an eligible research organisation.
There is no limit to the amount of funding you can apply for or the length of your project. We will fund 80% of your project’s full economic cost. This is an ongoing funding opportunity with an annual budget of £10 million.
Application rounds close every April and October.
Scope
You can apply for academically-led experimental medicine projects that are conducted in humans. Your project should be based round a clearly articulated gap in understanding of human pathophysiology and have a clear path to clinical impact.
Successful projects will produce new mechanistic insights, including those that may:
- identify opportunities to modify disease pathways
- enable the future development of novel therapeutic or diagnostic approaches
We welcome applications in all disease areas and interventions.
What your application must include
Your application must involve an experimental intervention or challenge in humans, which has been designed to validate a mechanistic hypothesis. The challenge may be, but is not limited to:
- pharmacological
- immunological
- physiological
- psychological
- infectious
Activities we support
The following types of work are eligible for support:
- the use of novel readouts or technologies related to early evaluation of clinical efficacy or pathogenic mechanism
- the use of drugs, other interventions or measures with established safety profiles in new settings or conditions (for example, repurposing drugs as tool compounds to probe disease mechanism)
- characterisation or phenotyping of subjects using samples from clinical studies may be included where there is a clear link to a current treatment strategy but should not be the sole focus of your application:
- limited, hypothesis-driven, retrospective sample analysis may be included at the start of the project to improve the design of the interventional, experimental medicine study
- milestone criteria should clearly detail what data is required from the confirmatory analysis for the project to progress
Prospective, nested studies within a larger cohort trial may be eligible provided they:
- can demonstrate added value
- are exploring disease mechanisms
- test a novel hypothesis
- address a different question to the main study
Competitive applications will aim to address a clear mechanistic question and provide strong rationale to justify the suitability of the experimental system proposed to test the presented hypothesis.
Specialties
Eligibility Requirements
Before applying for funding, check the Eligibility of your organisation.
UK Research and Innovation (UKRI)has introduced new role types for funding opportunities being run on the new UKRI Funding Service.
For full details, visit Eligibility as an individual.
Who is eligible to apply
To be eligible to apply for this funding opportunity you must:
- be employed by an eligible research organisation
- show that you will direct the project and be actively engaged in the work
If you do not have a contract of employment for the duration of the proposed project, by submitting an application the research organisation is confirming, if it is successful:
- contracts will be extended beyond the end date of the project
- all necessary support for the project and the applicants will be provided, including mentorship and career development for early career researchers
Sponsor Details
Sponsor Institute/Organizations: UKRI Medical Research Council
Address: UK Research and Innovation, Caxton House, Tothill Street, London SW1H 9NA
Grant
Letter Of Intent Deadline:
Oct 02, 2024
Final Deadline:
Oct 02, 2024
Funding Amount:
$10,000,000
5 awards available. There is no limit to the amount of funding you can apply for or the length of your project. We will fund 80% of your project’s full economic cost. This is an ongoing funding opportunity with an annual budget of £10 million.
Host Details
Affiliation: UKRI Medical Research Council
Address: UK Research and Innovation, Caxton House, Tothill Street, London SW1H 9NA
Website URL: https://www.ukri.org/opportunity/experimental-medicine/
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
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