Children’s Cancer Research Fund (CCRF) is a national nonprofit committed to finding safer, more effective therapies for kids battling cancer. Thanks to donors and partners around the country, we have contributed $235 million to research, education and awareness, and quality-of-life programs for childhood cancer families. We believe kids deserve safer, less toxic treatments, and we’re committed to funding groundbreaking research and services that enhance healing and care.
With this award, CCRF wishes to support research that reduces health disparities or inequities in childhood cancer incidence, presentation, access to care, outcome of therapy including adverse event rates, or survivorship.
Health disparities are defined here as “systemic, plausibly avoidable health differences adversely affecting socially disadvantaged groups.” (Braveman et al. 2011). CCRF will consider disparities based on race/ethnicity, sex or gender, socioeconomic status, language, geography, or other social determinants of health, so long as their evaluation is supported by the literature. Proposals that identify modifiable risk factors, elaborate mechanisms of disparities or inequities, or which plausibly propose to reduce them, will have greater priority for funding than proposals that simply describe them.
Award Information
Application Types
We will accept applications that are new or from a previous pilot study and applications (R03, R21) that have been reviewed but not funded by the National Institutes of Health (NIH).
Number of Awards
Funding of awards will be dependent on the availability of funds.
Award Budget
A budget for total costs of up to $125,000 per year may be requested.
Award Period
Maximum project period is 24 months
🔑 Previous Success Predictors – CCRF
🧪 1. Strong Pediatric Oncology Focus
Prior publications and work specifically in pediatric cancer, especially rare or hard-to-treat types like neuroblastoma, sarcomas, or DIPG.
Projects focused on translational research, survivorship, or precision medicine for children.
📊 2. Preliminary Data and Feasibility
Robust pilot data or proof-of-concept studies.
Previous success with internal funding, foundation seed grants, or NIH R03/K-series grants.
Demonstrated ability to complete proposed aims within the funding period.
🏫 3. Institutional Affiliation and Resources
Association with recognized children's hospitals, pediatric cancer centers, or research universities.
Access to relevant patient populations, pediatric biobanks, or clinical trials networks.
👩🔬 4. Early-Career Researcher Potential
Preference often given to junior investigators (postdocs, assistant professors) with:
Strong mentorship teams
Clear career development plans in pediatric oncology
🤝 5. Collaborative and Multidisciplinary Projects
Partnerships between basic scientists and clinicians, or cross-institutional collaborations.
Engagement with survivorship programs, psychosocial support researchers, or advocacy groups.
🎯 6. Alignment with CCRF Mission
Focus on improving outcomes or quality of life for children with cancer.
Projects that address gaps in treatment, access, or survivorship support.
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Principal Investigator (PI(s)) is invited to work with their organization to develop an application for support. Applicants need not be U.S. citizens; however, they must have a paid appointment at an academic, medical, or research institution in the United States.
Anyone serving on the Children’s Cancer Research Fund Research Advisory Committee is not eligible to apply for funding or to receive research support from a CCRF grant, for example as a coinvestigator.
In general, the following positions may be designated as PIs in CCRF applications:
• All tenured and tenure-track Assistant, Associate, and Full Professors
• All Research Assistant Professors, Research Associate Professors, Research Professors, and Clinical Professors
• All adjunct, visiting, emeritus, lecturers, or other faculty with the approval of their department or Dean of the relevant school or college
Sponsor Institute/Organizations: Children's Cancer Research Fund
Sponsor Type: Corporate/Non-Profit
Address: 1650 W 82nd St., Suite 400 Minneapolis, MN 55431
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Aug 15, 2025
Aug 15, 2025
$250,000
Affiliation: Children's Cancer Research Fund
Address: 1650 W 82nd St., Suite 400 Minneapolis, MN 55431
Website URL: https://childrenscancer.org/wp-content/uploads/2025/02/RFA-2025-Disparities-Award.pdf
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