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Division of Molecular and Cellular Biosciences Core Programs

U.S. National Science Foundation (NSF)

Program Title:

Division of Molecular and Cellular Biosciences Core Programs (MCB)

Synopsis of Program:

MCB supports research that promises to uncover the fundamental properties of living systems across atomic, molecular, sub-cellular, and cellular scales. The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, sub-cellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB encourages research exploring new concepts in molecular and cellular biology, while incorporating insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate principles that govern life at the molecular and cellular level. MCB also encourages research that exploits experimental and theoretical approaches and utilizes a diverse spectrum of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if these entail higher risk.
This solicitation calls for proposals in research areas supported by the four MCB core clusters, including: (i) structure, dynamics, and function of biomolecules and supra-molecular assemblies, especially under physiological conditions (Molecular Biophysics); (ii) organization, processing, expression, regulation, and evolution of genetic and epigenetic information (Genetic Mechanisms); (iii) cellular structure, properties, and function across broad spatiotemporal scales (Cellular Dynamics and Function); and (iv) systems and/or synthetic biology to study complex interactions through modeling or manipulation or design of living systems at the molecular-to-cellular scale (Systems and Synthetic Biology). All MCB clusters prioritize projects that integrate across scales, investigate molecular and cellular evolution, synergize experimental research with computational or mathematical modeling, and/or develop innovative, broadly applicable methods and technologies. Projects that bridge the intellectual edges between MCB clusters are welcome. Projects that integrate molecular and cellular biosciences with other sub-disciplines of biology are also welcome through the new Integrative Research in Biology (IntBIO) track.
Regarding health-related challenges, NSF supports basic research in all areas of the biological sciences and recognizes that this foundational research is likely to impact many different areas, including human health. MCB celebrates all the biological science discoveries funded through MCB awards that have had major impacts on health, environment, energy, food production, and other applications. Nevertheless, research focused exclusively on understanding human diseases and their treatment is normally outside of the scope of funding and will be returned without review unless that research significantly advances other fields such as engineering, computer science, or the mathematical and physical sciences.

Award Information

Anticipated Type of Award: Standard Grant or Continuing Grant

Estimated Number of Awards: 120

Anticipated Funding Amount: $110,000,000

$110M will be committed for the total budget of all new awards in each fiscal year.

Specialties

Cell Biology

Molecular Biology

Eligibility Requirements

Who May Submit Proposals:

Proposals may only be submitted by the following:
Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.
Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities.

Who May Serve as PI:

There are no restrictions or limits.

Sponsor Details

Sponsor Institute/Organizations: U.S. National Science Foundation (NSF)

Sponsor Type: Government/Federal

Address: 2415 Eisenhower Ave Alexandria, VA 22314 (703) 292-5111

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