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Developmental pathway funding scheme: invited stage two

Medical Research Council (MRC)

Opportunity status:

Open

Funders:

Medical Research Council (MRC)

Funding type:

Grant

Total fund:

£30,000,000

Publication date:

7 May 2025

Opening date:

7 May 2025 9:00am UK time

Closing date:

2 July 2025 4:00pm UK time

Apply for funding to develop and test novel therapeutics, medical devices, diagnostics and other interventions.

You must be invited to apply for stage two of this funding opportunity.

Your project can start and finish at any stage on the developmental pathway from early development, through pre-clinical refinement and testing to early-phase clinical studies and trials (up to phase 2a).

There is no limit on the amount of funding you can apply for, but it should be appropriate to the project. We usually fund 80% of a project’s full economic cost.

This is an ongoing funding opportunity. Application rounds close every March, July and November.

Specialties

General Medicine

Public Health

Eligibility Requirements

You can only apply for this funding opportunity if we have invited you to do so following a successful outline application.

To lead a project, you must be based at an eligible organisation. Check if your organisation is eligible.

Who is eligible to apply

To be eligible to apply for this funding opportunity you must:

show that you will direct the project and be actively engaged in the work
be part of a team that submitted a Developmental Pathway Funding Scheme (DPFS) stage one application and, after successful assessment, have been invited to submit a stage two application for this funding opportunity. Additional team applicants can be included that were not in the stage one application
or, be part of a team that have been invited to submit a DPFS stage two application as part of a panel-approved resubmission

If you do not have a contract of employment for the duration of the proposed project, by submitting an application the research organisation is confirming, if it is successful:

contracts will be extended beyond the end date of the project
all necessary support for you and the project will be provided, including mentorship and career development for early career researchers

International researchers

As MRC is a lead funder for this funding opportunity, international researchers can apply as ‘project co-lead (international)’.

Project co-leads (international) make a major intellectual contribution to the design or conduct of the project. Their contribution and added value to the research should be clearly explained and justified in the application, see Applicant and team capability to deliver.

Read the UKRI project co-lead (international) eligibility for more details. Contact us if you are uncertain about eligibility.

You should include all other international collaborators as project partners.

Equality, diversity and inclusion

We are committed to achieving equality of opportunity for all funding applicants. We encourage applications from a diverse range of researchers.

We support people to work in a way that suits their personal circumstances. This includes:

career breaks
support for people with caring responsibilities
flexible working
alternative working patterns

UKRI can offer disability and accessibility support for UKRI applicants and grant holders during the application and assessment process.

Sponsor Details

Sponsor Institute/Organizations: Medical Research Council (MRC)

Sponsor Type: Corporate/Non-Profit

Address: Polaris House North Star Avenue Swindon, SN2 1FL United Kingdom

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