Computational biologists apply theoretical principles and develop analysis and inference methods to decipher and understand biological systems. They are experts in quantitative approaches, data science and algorithms, while also having in-depth knowledge of complex biological processes. Particularly in cancer biology, there is a growing need for computational biology leaders with expertise and understanding in both quantitative and biological sciences.
 
The purpose of the Damon Runyon Quantitative Biology Fellowship is to identify computational scientists who innovatively combine quantitative analyses and modeling to solve biological questions. To achieve this goal the award program will support computational scientists who are deeply connected to biology labs so that they can bring their computational skills to bear on important biological questions, particularly in cancer. Additionally, the proposed mentored research training must reflect the individual's potential to develop into a productive, independent cancer research scientist.
 
This award program encourages scientists, trained in fields such as mathematics, computer science, physics, engineering, and/or a related field, to pursue research careers in computational biology under the joint mentorship of leaders in both computational science (“dry lab”) and cancer biology (“wet lab”). By investing in this area, Damon Runyon will bring additional attention to the importance of these specially trained scientists for making meaningful progress in cancer biology. The Foundation encourages all theoretical and experimental research relevant to the study of cancer and the search for cancer causes, mechanisms, therapies and prevention including molecular approaches to cancer prevention for inherited cancers.

Selection and Review

The Quantitative Biology Fellowship Award Committee, comprised of leaders in the field, will review applications and select awardees for approval by the Damon Runyon Cancer Research Foundation’s Board of Directors.

At the beginning of each review session the following Biases Statement is read aloud: As an organization, the Damon Runyon Cancer Research Foundation seeks to promote gender equality and increase diversity, in all of its forms, throughout our programs. Studies have demonstrated that often subtle and unconscious biases can dramatically affect outcomes in review processes and that by simply acknowledging that unconscious biases exist, we can combat their potential negative impact. To that end, please be aware of your potential unconscious biases when reviewing, scoring and discussing candidates and applications throughout the review process.

Applications will be evaluated by the following criteria:

• The quality of the applicant, their commitment to pursuing a research career as a computational biologist, and the potential to excel in cancer research.
• The capacity of the mentorship team (two required) to provide a robust training experience that will accelerate the development of the applicant’s scientific skills and prepare them to independently conduct high quality, innovative cancer-related research. Preference will be shown toward mentorship labs that are in close physical proximity to the applicant. The goal is to encourage frequent in person meetings and training in each lab. The labs may be located at the same or distinct institutions.
• Each Mentor, one in a “dry lab” and one in a “wet lab” setting, must have generated a proven track record in the successful training of other scientists.
• The qualifications, experience, and productivity of both the applicant and the Mentors.
• The quality of the research proposal (importance of the problem, originality of approach, appropriateness of techniques and clarity of presentation).
• Quality of the level of computational innovation introduced to solve the proposed problem. While building your own tools for analysis is not required, preference will be shown toward projects that create new or introduce novelty to existing technology.

EXPENSE ALLOWANCE

The $2,000 expense allowance is awarded to the laboratory in which the Fellow is working and can be used by the Fellow for their educational and scientific expenses. With written request to the Foundation from the Fellow, the expense allowance may be used to defray the cost of health benefits. The Fellow determines how they would like to spend the money with approval from their Mentors. It is not an allowance for institutional overhead, postdoctoral scholar registration fees or postdoctoral fellowship taxes. Institutions may not automatically deduct any fees from this allowance without the Fellow’s approval. If you have any questions on how the money may be spent, please contact the Foundation at 212.455.0520 or awards@damonrunyon.org.

DEPENDENT CHILD ALLOWANCE

The Foundation will provide a Dependent Child Allowance of $1,000 per child per year. There is no allowance for a spouse. Eligible Fellows must submit a dependent child allowance form and provide a copy of the birth or adoption certificate for each child. Payment of this allowance will be included in the initial payment to the host institution, or in the award year the child is born/adopted, and annually thereafter on the anniversary of the award activation date.

DEBT REPAYMENT PROGRAM

The Damon Runyon Cancer Research Foundation will retire up to $100,000 of any qualifying medical school debt still owed by the awardee. Payment will be made annually over the course of the award.
Note: Qualified candidates must first apply to the NIH Loan Repayment Program in order to be eligible for loan repayment from Damon Runyon (see Terms of the Award below).

Terms of the Award

All awardees must adhere to the terms of both our award statement and our invention policy.

Please note: The Damon Runyon Cancer Research Foundation will not modify the terms of its policies at the request of individual institutions. Policies have been approved by our Board of Directors, and we do not have the resources to negotiate separately with the many institutions that receive our support.

All awards are made to the sponsoring institution for support of the designated Fellow. An award does not constitute an employer-employee relationship between the Foundation and the recipient. Supplementation of stipends is permitted from either the host institution or Mentors' grants, but not by any other fellowship awards or grants. The total stipend should not exceed the level of support for other professionals at the same level of training in that institution.

Fellows are permitted to obtain additional awards or grants to cover research expenses only. Fellows are not permitted to hold any other award or grant that supplements their stipend. Fellows are required to seek approval from the Foundation before applying for any other award or grant. Budgetary overlap is not allowed. Therefore, it is critical that all current and pending grant support for your research be reported to the Foundation and the relationship of that support to the Damon Runyon funded project be explained.

Damon Runyon Fellowship awards are intended for full-time research.

Physician-scientists must devote their principal time (at least 80 percent) to Damon Runyon-supported research activities. Activities constituting the remaining 20 percent of time should be clearly specified in the application and in the annual progress report.

Damon Runyon Fellows are not permitted to pursue additional degrees during the course of their fellowship.

The Damon Runyon Foundation will allow up to 12 weeks of paid parental leave for birth/adoptive parents consistent with their institution’s policy. The Foundation must be notified in advance of the leave.

Visa Status

It is the responsibility of the host institution to make every effort to ensure that awardees are in compliance with federal immigration policy. If a Fellow’s visa status changes and/or expires, preventing the Fellow from working at their designated institution, Damon Runyon must be notified immediately. Failure to comply with this requirement may result in immediate termination of the award and may jeopardize any future awards to the institution and/or Sponsor by the Foundation.

MEDICAL SCHOOL LOAN REPAYMENT PROGRAM FOR PHYSICIAN-SCIENTISTS

The Damon Runyon Cancer Research Foundation (the “Foundation”) encourages more physicians to pursue research careers.  As part of this award program, the Foundation will pay up to $100,000 of outstanding medical school loans of Damon Runyon Fellowship Award recipients pursuant to the below policy.

Note: Qualified candidates must first apply to the NIH Loan Repayment Program in order to be eligible for loan repayment from Damon Runyon.

Qualifying loans: Debt incurred for tuition and direct educational expenses during medical school and any interest thereon.  Loans for general items or living expenses [e.g., housing, transportation, and consumables] do not qualify for this program.  Loans must be from a government entity, academic institution, or commercial or chartered lending institution.  Qualifying medical school loans, which have been combined or refinanced with non-qualifying loans, will be partially eligible based on the ratio of eligible and ineligible expenses included.

Eligibility and amount of support: Up to $100,000 debt will be paid in the aggregate over the three-year award period not to exceed $33,333 in any one-year period, if the following conditions are met:

(i) Participants in this program must submit documentation regarding the loans (e.g., receipts and supporting documents for tuition and directly related expenses, loan agreements, and payment information) to the Foundation within one month of acceptance of a Fellowship Award to determine whether they qualify for this program. Documentation of loan status and payment information must be provided to the Foundation annually, no later than one month prior to the award renewal date, as a condition of continued participation.
(ii) Participants enrolled in NIH-sponsored loan repayment programs or any other debt relief programs must disclose the details of such agreements to the Foundation.
(iii) Participants must agree to refund all amounts paid under this loan repayment program if they terminate the Fellowship Award prior to completion of the three-year term.

Payments: For each year of eligibility, the Foundation will pay directly to each lender an amount representing the total payments owed by the participant for all qualifying loans for that year up to an aggregate maximum of $33,333 (“Annual Debt Payments”).  If the participant has qualifying loans with annual payments in excess of $33,333, the Foundation, in its discretion, will determine which loans it will pay.

Consolidated loans: Participants must submit the loan agreement for consolidated loans as well as loan agreements for each of the underlying loans.

Leave without pay: Loan repayments will not be made during leaves of absence unless written permission is granted by the Foundation.

Obligations not qualifying for repayment: (i) Loans not obtained from a government entity, academic institution, or a commercial or other chartered lending institution such as loans from friends, relatives, or other individuals.  (ii) Delinquent loans, loans in default, loans not current in their payment schedule, or loans already repaid.  (iii) Late fees, penalty fees, additional interest charges, or collection costs.

Reimbursement for increased income tax liabilities: Loan repayments made to lenders represent taxable income to program participants.  This income will be reported annually to the IRS and may result in an increase in participants’ Federal, State, and Local tax liabilities.  To offset tax liability increases, the Foundation will approximate the added liability using the applicable tax rates each year and pay this amount directly to the participant at the time of each repayment (“Additional Tax Payment”).  For purposes of the foregoing, the assumed tax rate shall be determined by the Foundation, in its sole discretion, and may or may not equal the tax rate that actually applies to the participant.

Payback Agreement: If a participant in this program terminates their Fellowship Award prior to the end of the award term, the Foundation shall, in its sole discretion, be entitled to require repayment by the participant of all Annual Debt Payments and Additional Tax Payments.  The Foundation reserves the right to waive this payback requirement if the participant continues to conduct cancer research after early termination of the Fellowship Award.  This payback will be paid over the same period of time and in the same amounts as the initial payments by the Foundation.

Should the Fellow and/or Mentor wish to discontinue the project, leave the designated institution or modify any aspect of the award, they must seek approval from the Damon Runyon Cancer Research Foundation in advance. Failure to comply with this requirement may jeopardize any future awards to the institution and/or Mentor by the Foundation.

Confidentiality Agreements

Fellows may not enter into confidentiality agreements that prevent or delay them from publishing and/or presenting their Damon Runyon-supported research.

Reporting

SCIENTIFIC

Second- and third-year funding of awards is contingent upon satisfactory review of the annual progress reports. All reports are kept strictly confidential. The reports serve as an auditing tool to monitor research progress and assure that the Fellow's research is on target with the funded project.

At the end of the 11th and 23rd months of funding, the Fellow must submit a detailed progress report that includes:

1. A summary of research performed during the award year and evaluation of the results. The summary should be technical, but targeted to a general scientific audience. It should be sufficiently detailed such that the Fellow's research activities over the award year are clearly articulated. The report should include a statement highlighting the relation between computational work and cancer research. Figures and references may be included if appropriate. The report must be signed by both the Fellow and the Mentors. The report should not exceed three pages.
2. A brief, lay abstract of research performed during the award year, including how the research is relevant to cancer. The lay summary should not exceed one page.
3. A bibliography of publications from the award year (submit pdf copies of publications).
4. A request for Open Access fee reimbursement, if applicable.
5. A list of conferences and seminars attended, and presentations given during the award year.
6. A brief description of collaborations and partnerships related to the Damon Runyon-funded research, with either academic and/or industry scientists. Please identify your collaborator(s) and their academic/industrial affiliation(s).
7. A brief summary, from the Mentors, assessing the Fellow’s scientific progress and professional development.
8. A completed intellectual property disclosure form.
9. A completed expense allowance usage form for the next year of funding.

At the completion of the fellowship, the Fellow must submit a detailed progress report that includes:

1. A summary of research performed during the period of the Fellowship and evaluation of the results. The summary should be technical, but targeted to a general scientific audience. It should be sufficiently detailed such that the Fellow's research activities over the award period are clearly articulated. The report should include a statement highlighting the relation between computational work and cancer research. Figures and references may be included if appropriate. The report must be signed by both the Fellow and the Mentors. The report should not exceed three pages.
2. Two abstracts (one lay and one scientific) of their accomplishments over the term of the award.
3. A bibliography of all publications resulting from the research (submit pdf copies of publications).
4. A request for Open Access fee reimbursement, if applicable. 
5. A list of conferences and seminars attended, and presentations given during the award year.
6. A brief description of collaborations and partnerships related to the Damon Runyon-funded research, with either academic and/or industry scientists. Please identify your collaborator(s) and their academic/industrial affiliation(s).
7. A statement indicating how the Damon Runyon award made a difference to the Fellow.
8. A statement of future plans.
9. An up-to-date curriculum vitae.
10. A brief summary, from the Mentors, assessing the Fellow’s scientific progress and professional development.
11. A completed intellectual property disclosure form.

FINANCIAL

The institution's financial officer must maintain a separate account including receipts for each fellowship, and this account must be available for audit by representatives of the Foundation. Reports of expenditures on forms provided by the Foundation must be submitted within 60 days of the end of each award year. Any unexpended expense allowance may be carried over to the next award year, but any unexpended stipend must be returned to the Foundation at the end of each fellowship year. Upon termination or expiration of the fellowship, a final report of expenditures, with the refund of any unexpended balance, must also be submitted within 60 days.

Financial Expenditure Report Preparation Guidelines:

1. Please use the Damon Runyon Fellowship Financial Expenditure Report form.
2. Indicate any carry-over of the previous year’s expense allowance in the second row as an amount received in addition to the current year’s $2,000 allowance.
3. If the expense allowance was used for travel, please provide the following details:
   a. name and location of scientific meeting or conference attended
   b. dates of meeting/conference
   c. use of funds; restricted to registration fee, lodging, meals, transportation (if by train or plane, must be coach class ticket only).
4. If the expense allowance was used for supplies, please provide a list of the general categories of the supplies. If any one piece of equipment purchased costs $1,500 or more, please provide the name of the item, date of purchase, and price.
5. The only allowable purchases that may be listed in the “other” category are:
   a. health insurance (if requested by the Fellow)
   b. scientific subscriptions
   c. contact our office for approval of any items not listed here
6. The Foundation requires that the Dependent Child Allowance be reported as received in the annual financial report but does not require reporting on how the allowance is spent.

Publications, Presentations and Websites

Publications (including abstracts of presentations at scientific or clinical meetings) resulting from projects supported by the Foundation must carry the following acknowledgment: "[Name of Awardee] is a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation (DRQ-[___])."

Contact awards@damonrunyon.org if you do not know your DRQ.

Awardees should identify themselves as Damon Runyon Fellows, particularly when presenting their work at professional conferences and on their websites. Download a copy of the Damon Runyon Cancer Research Foundation logo for inclusion in Power Point presentations, posters, and on your website.

Damon Runyon-Jake Wetchler Award for Pediatric Innovation

The Damon Runyon-Jake Wetchler Award for Pediatric Innovation is given annually to a third-year Damon Runyon Fellow whose research has the greatest potential to impact the prevention, diagnosis, or treatment of one or more forms of pediatric cancer. The research can be focused on basic mechanistic or translational studies, as long as it has the potential to impact pediatric cancers. The award is a one-time $5,000 prize and the winner will be announced at the Fellows’ Virtual Symposium in September. The application is due on or before August 15.

Damon Runyon-Jake Wetchler Award for Pediatric Innovation Application Guidelines

Damon Runyon-Dale F. Frey Award for Breakthrough Scientists

At the end of the Fellowship, there are often a select few Damon Runyon Fellows who have greatly exceeded the Foundation’s highest expectations. To catapult their research careers—and their impact on cancer—the Foundation will make an additional investment in these exceptional individuals by selecting them as recipients of the Damon Runyon-Dale F. Frey Award for Breakthrough Scientists. Damon Runyon Fellows are eligible to apply for the Dale F. Frey Award one time only, in the third year of their award. The application is due on or before July 15.