Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for the RNA Modifications Driving Oncogenesis (RNAMoDO) initiative. This NCI initiative aims to promote fundamental studies in the emerging area of RNA modifications that underlie the oncogenic process, focusing on the central role of RNA modifications in translational reprogramming of cancer cells. RNA modifications have been recognized to exert a substantial impact on gene expression and function and their de-regulation has been linked to the cancer phenotype. In particular, recent insights point to a crucial role for mRNA, tRNA, and rRNA modifications in translational reprogramming during tumor initiation, progression, and adaptation to therapy. However, the molecular mechanisms underlying this reshaping of the translatome caused by dynamic changes in RNA modifications, as well as the interplay between different RNA modifications within and/or across RNA molecules during translation, are not understood and represent the focus of this initiative. This new program will be composed of up to five U01 grants that will be supported by this NOFO.
Deadlines:
RFA-CA-24-029 Expiration Date November 05, 2024
Sponsor Institute/Organizations: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Nov 04, 2024
$3,250,000
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.