Trialect

Active

Notice of Special Interest (NOSI): The Road to Prevention of Stillbirth

National Institutes of Health

This Notice of Special Interest (NOSI) aims to support transdisciplinary research to elucidate the genotypic, phenotypic, and environmental underpinnings of stillbirth and to identify potential targets for intervention and prevention.

Research supported by this NOSI is expected to:

Contribute to the discovery of new risk factors and interactions with stillbirth.
Explore the development of real-time placental evaluation imaging techniques that may lead to identification of standardized pathologic patterns predictive of risk for stillbirth.
Expand knowledge of the mechanisms by which specific genetic and environmental risk factors and their interactions lead to stillbirth.
Identify the factors contributing to racial, ethnic, and nativity disparities in stillbirth.
Develop the most appropriate strategies for stillbirth prevention, with an emphasis on high-risk communities.
Establish baseline normative data on pregnancy physiology that will aid in implementing best practice(s) in care in subsequent pregnancies after stillbirth.
Develop approaches for identifying and stratifying pregnant people at increased risk of stillbirth.
Improve clinician and healthcare provider tools for stillbirth risk assessment.
Develop targeted clinical interventions for the prevention of stillbirth using indicators such as placental development, function, and biomarkers, fetal movement, and fetal growth.
Develop and implement approaches to enable best decision practices for timing of delivery for pregnant people with risk factors for stillbirth.
Assess quality of care and link specific care interventions to data on outcomes to learn about the psychological burden on the pregnant person, their family, and healthcare providers.

This notice applies to due dates on or after October 5, 2023, and subsequent receipt dates through November 17, 2026. No applications will be accepted on or after November 17, 2026.

NOT-HD-23-021