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Notice of Special Interest (NOSI): Sex and Gender Differences in Alzheimers Disease and Alzheimers Disease-Related Dementias (AD/ADRD)

National Institutes of Health

This NOSI promotes multidisciplinary research to clarify sex and gender differences in the risk, development, progression, diagnosis, and clinical presentation of Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD). Studies that examine sex and gender differences in outcomes (e.g., clinical, functional, well-being) among people living with AD/ADRD as well as AD/ADRD caregiving-related outcomes are also relevant. Broad areas of interest include biological (e.g., hormonal, genetic, metabolic, comorbidity-related), neuroscientific (e.g., neural systems and functions), behavioral (e.g., physical activity, substance use, social engagement), social (e.g., history of maltreatment or adversity, parenthood, marital status, educational attainment, socioeconomic and employment status), psychological (e.g., depression, cognitive functioning, socio-emotional functioning and self-regulation, stress reactivity, personality), healthcare profession (e.g., provider knowledge and attitudes about dementia) and healthcare system-level (e.g., access to care) factors and processes that separately, or together, may drive observed differences by sex and gender and/or may operate differently by sex and gender. Studies that account for methodological and measurement issues that may drive sex and gender differences are also of interest.

This notice applies to due dates on or after March 11, 2022 and subsequent receipt dates through November 13, 2024.

Application Due Date(s): March 11, 2022; July 8, 2022; Nov 14, 2022; March 10, 2023; July 10, 2023; Nov 13, 2023; March 11, 2024; July 9, 2024; Nov 12, 2024

NOT-AG-21-050