This Notice of Special Interest (NOSI) is to solicit applications proposing studies utilizing available biologic and environmental samples collected as part of the birth cohort study, Systems Biology of Early Atopy (SUNBEAM, NCT04798079 ), to discover and advance the understanding of novel and established clinical, environmental, biological, and genetic early-life factors in the development of allergic diseases. Studies using these samples are expected to give a deeper understanding of mechanisms contributing to the development of allergic diseases, disease endotypes, and will identify molecular targets for disease prevention.
SUNBEAM is collecting biologic and environmental samples as well as health and exposure history from parents and offspring from the time of enrollment (during gestation; samples and data from the parents) through 3 years of age (samples and data taken from parents and offspring) for rigorous analyses. In addition, SUNBEAM is evaluating the offspring for food allergy (FA) and atopic dermatitis (AD) at every study visit starting at the 2-month visit, for allergic rhinitis and conjunctivitis starting at the 24-month visit, and for recurrent wheeze at the 36-month visit. The SUNBEAM biologic samples are being collected and stored to allow for extensive omics approaches, including genomic, epigenomic, transcriptomic, proteomic, metabolomic, and microbiomic analyses.
This notice applies to due dates on or after October 5, 2023 and subsequent receipt dates through July 5, 2026.
NOT-AI-23-058
Sponsor Institute/Organizations: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Oct 05, 2024
Varies
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
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