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Notice of Special Interest (NOSI): NIDCD is Interested in Supporting Research on the Impact of Post-Acute Sequelae of SARS-CoV-2 Infection on Mission Specific Sensory and Communication Disorders

National Institutes of Health

Post-acute sequelae of SARS-CoV-2 (PASC), also referred to as long COVID, is defined as signs, symptoms, and conditions that continue or develop after initial COVID-19 infection. Such signs, symptoms, and conditions linger or develop 4 or more weeks following the acute infection, and can last weeks, months, and even years. Furthermore, PASC-related symptoms are wide ranging, and can have cardiopulmonary, gastrointestinal, dermatologic, endocrine, psychiatric and/or neurological manifestations, including sensory dysfunction and cognitive-communication difficulties. Further research is critical to understand the symptomatology, pathogenesis, and underlying mechanisms of PASC. NIDCD invites applications for research on PASC in relation to NIDCD’s scientific programs of hearing, balance, taste, smell, voice, speech and language. When appropriate, NIDCD encourages multi-disciplinary approaches to move the research beyond in vitro and animal models.

Areas of research encouraged through this NOSI must focus on the manifestations of PASC in relation to NIDCD’s scientific mission areas and include, but are not limited to:

Studies on the prevalence, onset, and resolution of acquired deficits among patients with PASC across the lifespan
Characterization of long-term post-acute sequelae following SARS-CoV-2 infection
Research on the genetic predispositions, environment factors, and health conditions contributing to PASC susceptibility and severity
Studies on the underlying molecular mechanisms and pathobiology leading to dysfunction associated with PASC
Research on potential toxicity or tissue damage to the auditory, vestibular, or chemosensory systems due to infection and therapeutics related to PASC
Development and validation of animal models and in vitro systems replicating aspects of PASC
Studies of the multiple mechanisms proposed to play a role in PASC (ongoing exacerbated inflammatory response, persistent viral reservoirs, SARS-CoV2-evoked autoimmunity and others)
Multidisciplinary collaborative research to study PASC and to develop approaches (such as technical innovations related to telemedicine) for providing effective and equitable health services

This notice applies to due dates on or after January 30, 2024 and subsequent receipt dates through January 30, 2027.

NOT-DC-24-001

Specialties

Others

Pulmonology

Otolaryngology

Eligibility Requirements

This notice applies to due dates on or after January 30, 2024 and subsequent receipt dates through January 30, 2027.

Submit applications for this initiative using one of the following funding opportunities or any reissues of these opportunities through the expiration date of this notice.

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type:

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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