This Notice of Special Interest (NOSI) solicits research on immunologic characterization of mice with diverse microbial exposures (commonly referred to as “dirty mice”) to determine their usefulness as research tools to advance understanding of human immune function in homeostasis and in response to infectious or immune-mediated diseases.
This NOSI aims to stimulate research proposing to characterize immune system development, regulation and function in dirty mice via: 1) comparison of (a) mouse line(s) housed in a “clean” environment with animals housed in a “dirty” facility during homeostasis or in various infectious or immune-mediated disease models; or 2) in vitro comparison of immune profiles in primary human cells and primary cells from dirty mice. These studies will advance our understanding of the impact of a host’s microbial exposure and experience on the development and maintenance of immunity and provide the necessary data to encourage broader use of dirty mouse models in immunologic studies.
This notice applies to due dates on or after February 16, 2022 and subsequent receipt dates through January 7, 2025 .
NOT-AI-21-072
Sponsor Institute/Organizations: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Oct 16, 2024
Varies
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
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