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Notice of Special Interest (NOSI): Exploratory Cancer Immunology Projects and Technologies (ExCITe)

National Institutes of Health

Through this Notice of Special Interest (NOSI) on Exploratory Cancer Immunology Projects and Technologies (ExCITe), the National Cancer Institute intends to encourage R21 applications proposing innovative high-risk/high-reward research projects, that test novel hypotheses or develop novel technologies, to advance our understanding of cancer immunology. Research projects should focus on fundamental areas of cancer immunology, including innate and adaptive immune responses, tumor-immune ecosystems and their dynamic interactions, the immune response to metastases, systemic immune networks, immunosurveillance, tumor immune evasion, or immunomodulation. Projects should be distinct in scope and focus from those supported through the traditional R01 mechanism. ExCITe studies may involve considerable risk but have the potential to lead to research breakthroughs or the development of novel techniques, agents, methodologies, models, or applications that could have a major impact in cancer immunology and cancer immunotherapy research.

R21 applications submitted through the ExCITe NOSI should propose innovative high-risk/high-reward research projects, that test novel hypotheses or develop novel technologies, to advance our understanding of cancer immunology. Applicants should propose research studies to address fundamental aspects in the field of tumor immunology and/or innovative ways to enhance anti-cancer immunity. Innovative approaches that target both primary tumor and metastases are encouraged. Establishing new or improved in vivo/in vitro models to study the dynamics of tumor-immune ecosystems are also encouraged.

This notice applies to due dates on or after February 16, 2024 and subsequent receipt dates through November 17, 2026.

NOT-CA-24-016

Specialties

Cancer

Oncology

Immunology

Eligibility Requirements

Applicants are strongly encouraged to discuss their applications with Scientific/Research contact listed below prior to submission to help assess whether their application is responsive to this NOSI.

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type:

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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