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Notice of Special Interest (NOSI): Discovery and Development of Oral Small-molecule Direct-acting Antivirals Targeting Viruses of Pandemic Potential

National Institutes of Health

This Notice of Special Interest (NOSI) invites applications focused on the preclinical discovery, evaluation and development of oral direct-acting small molecule therapeutics targeting selected viruses of pandemic potential. The ultimate goal of this NOSI is to build a more robust pipeline of candidate antiviral drugs suitable for widespread use in the community in future outbreaks and/or pandemics.

Typical drug discovery programs require several years to progress through initial lead series identification and optimization to selection of a candidate drug for clinical trials. Availability of a broader range of antiviral compounds may help shorten the time needed to identify promising lead drug candidates when unexpected outbreaks arise. This NOSI builds on the  Antiviral Program for Pandemics , which was launched in 2021 with funding from the American Rescue Plan.

This notice applies to application receipt dates on or after October 5, 2024 , and subsequent receipt dates through July 16, 2027 .

NOT-AI-24-053

Sponsor Institute/Organizations: National Institutes of Health

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

Grant

Final Deadline:

Oct 05, 2024

Funding Amount:

Varies

Not Verified

This program has not been verified by Trialect.

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